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Pharmaceutical composition used for resisting intestinal tract inflammatory injuries, and preparation method and applications thereof

A technology for inflammatory injury and composition, which is applied to the field of pharmaceutical compositions for resisting intestinal inflammatory injury and the field of preparation thereof, can solve the unclear effect of ulcerative colitis, whether there are differences in the curative effect of Sophora flavescens and licorice, etc. question

Inactive Publication Date: 2015-08-26
贺平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although Sophora flavescens and Radix Glycyrrhiza have been documented in the treatment of dysentery, its effect on ulcerative colitis is not clear; the therapeutic effect of Sophora flavescens and Radix Glycyrrhizae on ulcerative colitis is only to control the symptoms, or to eliminate the cause. Clear; in addition, it is not clear whether there is a difference in curative effect between the combination of Sophora flavescens and licorice

Method used

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  • Pharmaceutical composition used for resisting intestinal tract inflammatory injuries, and preparation method and applications thereof
  • Pharmaceutical composition used for resisting intestinal tract inflammatory injuries, and preparation method and applications thereof
  • Pharmaceutical composition used for resisting intestinal tract inflammatory injuries, and preparation method and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] At room temperature, weigh 4.17 kg of Sophora flavescens and 0.83 kg of licorice (5 kg in total), make coarse powder, add 30 kg (6 times) of water and decoct twice for 3 hours each time, filter the decoction, and the filtrate is routinely Concentrate under reduced pressure to an extract with a relative density of 1.25 g / ml.

Embodiment 2

[0021] At room temperature, weigh 3.57 kg of Sophora flavescens and 1.43 kg of licorice (5 kg in total), make coarse powder, add 70 kg (14 times) of water and decoct once for 2.5 hours, filter the decoction, and decompress the filtrate Concentrate to the extract whose relative density is 1.15g / ml.

Embodiment 3

[0023] At room temperature, weigh 2.5 kg of Sophora flavescens and 2.5 kg of licorice (5 kg in total), make coarse powder, add 50 kg (10 times) of water and decoct twice for 2 hours each time, filter the decoction, and the filtrate is routinely Concentrate under reduced pressure to an extract with a relative density of 1.20 g / ml.

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Abstract

The invention belongs to the technical field of medicine, and discloses a pharmaceutical composition used for resisting intestinal tract inflammatory injuries, and a preparation method and applications thereof. The pharmaceutical composition is used for treating ulcerative colitis, and is prepared via combination of radix sophorae flavescentis and liquorice at a weight ratio of 1:0.25-4. The pharmaceutical composition is prepared via water extraction condensation. The pharmaceutical composition possesses excellent curative effect on ulcerative colitis, and the curative effect is better than that of radix sophorae flavescentis or liquorice.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a pharmaceutical composition for resisting intestinal inflammatory injury, a preparation method and application thereof. Background technique [0002] Ulcerative colitis is a chronic nonspecific intestinal inflammatory disease of unknown etiology. The lesions of ulcerative colitis mainly involve the colonic mucosa and submucosa, and the clinical manifestations are persistent or recurrent diarrhea, mucus pus and blood in the stool accompanied by abdominal pain, tenesmus, and stomatitis and abdominal mass are rare. [0003] The goal of treatment for ulcerative colitis is to inhibit the inflammatory response as soon as possible, relieve symptoms and prevent recurrence, and improve the quality of life of patients. At present, the treatment methods of Western medicine are limited. Aminosalicylic acids and glucocorticoids are conventional drugs for the treatment of ulcerative colitis....

Claims

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Application Information

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IPC IPC(8): A61K36/489A61P1/04
Inventor 杨鹏张琰贺平石磊党学良赵军
Owner 贺平
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