Modularly-assembled protein structure model

A technology of protein structure and assembly structure, applied in the field of scientific research equipment and teaching, can solve the problems of inaccurate display of peptide bonds and peptide planes, misleading, difficult to apply, etc., and achieve the effect of standardized production and manufacturing

Active Publication Date: 2015-09-02
台州达辰药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method cannot accurately display the formation of peptide bonds and peptide planes, and it is also difficult to display dihedral angles. The spatial structure formed by paper clip hooks is inaccurate, arbitrary and misleading, and it is difficult to be applied in the field of scientific research.
[0004] In the existing teaching and research process of protein structure and function, there is no model that can simply and intuitively show the protein from the primary structure to the three-dimensional structure, causing some confusion to practitioners and students

Method used

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  • Modularly-assembled protein structure model
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  • Modularly-assembled protein structure model

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Example 1 Primary Teaching Aids for Protein Structural Models

[0066] Each set of teaching aids includes 3 amino modules, 3 carboxyl modules, 60 general modules, and 60 amino acid feature modules.

[0067]

[0068] Except for the carboxyl module, the atoms and bonds in the other modules are all in one plane. The atoms and bonds inside the module are fixed, and the modules are connected by connecting bonds, and the connection can be rotated.

Embodiment 2

[0069] The assembly of embodiment 2 insulin structure model

[0070] Such as figure 1 As shown, insulin consists of two chains, A and B.

[0071] 1) Using the complete set of teaching aids in Example 1 and 6 cysteine ​​side chain modules, each module is assembled according to the amino acid sequence of the A and B chains, and the assembly sequence of the modules is: amino module---amino acid characteristic module 1-general module 1 - Amino Acid Feature Module 2 - General Module 2... Amino Acid Feature Module n-Carboxyl Module. The name of the corresponding amino acid is marked on the aa of each amino acid feature module. A cysteine ​​side chain module is attached to the cysteine ​​signature module aa.

[0072] 2) According to the insulin dihedral angle data, rotate the connection key between the general module and the characteristic module of the corresponding amino acid to obtain the secondary structure and the tertiary structure of the insulin molecule.

[0073] 3) Accor...

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Abstract

The invention discloses a modularly-assembled protein structure model which is formed by repeatedly connecting common modules (peptide planar modules) and amino acid feature modules ([alpha] carbon atoms and side chain modules) in sequence, and connecting an amino module and a carboxyl module at two ends, namely, the amino module-an amino acid feature module 1-a common module 1-an amino acid feature module 2-a common module 2...an amino acid feature module n-the carboxyl module. According to the modularly-assembled protein structure model provided by the invention, peptide planes and [alpha] carbon atoms are taken as basic structure modules; a module which can accurately display spatial configuration of a primary structure, a secondary structure, a tertiary structure, a quaternary structure and the like of protein is established; and standard production and manufacturing of the model, understanding of students, and application to scientific research are facilitated.

Description

technical field [0001] The invention belongs to the technical field of teaching and scientific research appliances, and in particular relates to a protein structure model for modular assembly. Background technique [0002] Protein is a biomacromolecule with three-dimensional structure, which plays very important functions in life activities. The structure of protein has multiple levels such as primary structure, secondary structure, tertiary structure and quaternary structure. The understanding and research of protein spatial structure is an important part of studying the relationship between biomolecules and using biomacromolecules for production practice. ring. The conventional ball and stick model can well illustrate the structure of small chemical molecules. However, proteins have large molecular weights, many types and numbers of atoms, and complex spatial structure changes. Relying on balls and sticks to splice one by one, only some amino acids or simple polypeptide m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G09B23/26
CPCG09B23/26
Inventor 杨仲毅
Owner 台州达辰药业有限公司
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