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Nootropic compositions for improving memory performance

A composition and memory technology, applied in the direction of drug combination, active ingredient of heterocyclic compound, active ingredient of anhydride/acid/halide, etc.

Active Publication Date: 2015-09-02
PHARNEXT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But most of these drugs are not free from harmful side effects

Method used

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  • Nootropic compositions for improving memory performance
  • Nootropic compositions for improving memory performance
  • Nootropic compositions for improving memory performance

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0209] All animal operations are carried out in accordance with existing laws and regulations (Decree No. 87-848 of October 19, 1987: implemented in April 1988, introducing the guideline 86 / 609 / EC into French law, by No. 5, 2001 Decree No. 2001-464 of 29 June and amended by decision of 20 June 2001).

[0210] I. Memory Improvement in Animals

[0211] In healthy animals, short-term and long-term memory are assessed using different assays commonly used to measure learning and memory performance.

[0212] A. Short-term and long-term memory enhancement in healthy animals.

[0213] Eleven-month-old C57Bl / 6 mice were used. They were housed in groups (5-10 mice per cage) and maintained at a temperature with controlled temperature (21-22°C) and a reversed light-dark cycle (12h / 12h; lights on: 17:30-05: 30; light off: 05:30-17:30) in the room, free to eat and drink.

[0214] 1) Administration of the compound

[0215] Drugs were prepared fresh by dissolving in water just prior to e...

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Abstract

The invention relates to compositions and methods for improving memory and related functions as alertness, attention, concentration, learning, and language processing. More particularly, the invention relates to compositions comprising at least two drugs selected from cinacalcet, baclofen, acamprosate, mexiletine, sulfisoxazole and torasemide useful to enhance memory and related functions in healthy subjects or subjects suffering from conditions or disorders having a negative impact on their memory.

Description

technical field [0001] The present invention relates to nootropic compositions and their uses, such as stimulating cognition. More specifically, the present invention provides novel compositions comprising at least two drugs selected from the group consisting of cinacalcet, baclofen, acamprosate, mexiletine, sulfisoxazole and torasemide, It is used to enhance memory and mental functions such as vigilance, attention, reasoning, concentration, learning or language processing in a subject in need thereof. Background technique [0002] In a rapidly developing society, with more constant exposure to information saturation and demands on mental performance, there is a need for drugs that can maintain mental functions such as memory, cognition, intelligence, motivation, attention and concentration increasing demand, even in healthy individuals. Such drugs are named nootropics, smart drugs (smart drugs), memory enhancers, cognitive enhancers, and intelligence enhancers, and includ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/135A61K31/137A61K31/185A61K31/195A61K31/44A61K31/635A61P25/00A61P25/16A61P25/18A61P25/24A61P25/36A61P39/02A61P43/00
CPCA61K31/42A61K31/635A61K31/195A61K31/16A61K31/137A61K31/135A61K31/185A61K31/138A61K31/197A61K45/06A61K31/44A61P25/00A61P25/14A61P25/16A61P25/18A61P25/22A61P25/24A61P25/28A61P25/36A61P39/02A61P43/00A61K2300/00
Inventor D.科恩S.纳比罗克金I.查马科夫
Owner PHARNEXT
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