A kind of preparation method of tamsulosin hydrochloride with high optical purity

A technology of tamsulosin hydrochloride and optical purity, applied in the fields of medical technology and chemistry, can solve the problems of time-consuming and laborious separation of enantiomers, low yield and high cost, and achieves the solution of rework treatment, good reproducibility, low cost effect
CN104926699BActive Publication Date: 2018-09-25CHENGDU LIKAI CHIRAL TECH
14 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
CHENGDU LIKAI CHIRAL TECH
Publication Date
2018-09-25

Smart Images

  • Figure 1
    Figure 1
Patent Text Reader

Abstract

The invention discloses a preparation method of tamsulosin hydrochloride with high optical purity, and belongs to a medicine technology and a chemical field. A recrystallization method is adopted, crude products of (R)-5-(2-(2-(2-ethoxyphenoxy) ethyl amino) propyl)-2-methoxyl phenyl sulfonamide hydrochloride are refined, so that pure products of the (R)-5-(2-(2-(2-ethoxyphenoxy) ethyl amino) propyl)-2-methoxyl group sulfonamide hydrochloride of which the e.e. value is larger than 99.8% is obtained; a crystallizing solvent adopted by the recrystallization method is a mixed solvent consisting of an organic solvent and water, the organic solvent is selected from one of methanol, ethyl alcohol, acetone, acetonitrile and isopropyl alcohol, and the recrystallization temperature is under 15 DEG C. The preparation method disclosed by the invention is simple to operate, short in period, low in cost and good in repeatability, and can solve the inevitable problem of rework for treatment in the industrial production.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to the fields of medical technology and chemistry, in particular to a preparation method of tamsulosin hydrochloride with high optical purity. Background technique

[0002] Tamsulosin Hydrochloride (Tamsulosin Hydrochloride), chemical name: (R)-5-(2-(2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxy Benzenesulfonamide hydrochloride is a new type of long-acting α-1 adrenoceptor antagonist. The drug has the characteristics of good selectivity, fast curative effect and few side effects, and is widely used clinically for the treatment of benign prostatic hyperplasia.

[0003] Tamsulosin Hydrochloride (CAS: 106463-17-6, English name: Tamsulosin Hydrochloride) is a chiral compound, and its medicinal active ingredient is the R-configuration enantiomer (I). In order to ensure the selectivity and efficacy of clinical medication, the pharmacopoeias of various countries have higher requirements for the optical purity of tamsulosin hydrochlo...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More