3-hydroxy olefine acid derivative and its preparation and application
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- INST OF CHEM CHINESE ACAD OF SCI
- Publication Date
- 2009-05-27
- Estimated Expiration
- Not applicable · inactive patent
Smart Images
Figure 1 
Figure 2 
Figure 3
Abstract
Description
technical field
[0001] The invention relates to a 3-hydroxyalkenoic acid derivative and its preparation method and application. Background technique
[0002] Olefin cross-metathesis reaction (Olefin Cross-metathesis) is an effective means to construct carbon-carbon bonds. In recent years, with the continuous development of various catalysts, the recycling and reuse of catalysts has become possible, not only the catalytic activity has been significantly improved, the reaction time has been gradually shortened, and the required reaction temperature has also been greatly reduced. Sensitivity has been reduced.
[0003] The (R)- or (S)-3-hydroxy acid fragment is a common fragment in natural products such as glycolipids and cyclic peptides. It not only exists in all lipid A (Lipid A) molecules, but also participates in the construction of sulfobacin A , the molecular skeleton of natural products such as lobatamide C. According to comprehensive literature reports, there are thre...