A Pulsatilla extract and its application in the preparation of medicines for preventing and treating pulmonary fibrosis

A technology for pulmonary fibrosis and Pulsatillae, which is applied in the field of medicine, can solve the problems that Pulsatilla extracts have not been found to prevent and treat pulmonary fibrosis.

Active Publication Date: 2018-06-12
HENAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Pulsatilla extract has no research reports on the prevention and treatment of pulmonary fibrosis

Method used

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  • A Pulsatilla extract and its application in the preparation of medicines for preventing and treating pulmonary fibrosis
  • A Pulsatilla extract and its application in the preparation of medicines for preventing and treating pulmonary fibrosis

Examples

Experimental program
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Effect test

Embodiment 1

[0035] The Psyllium pulsatillae extract of the present invention is obtained by the following extraction methods:

[0036] a, taking Pulsatillae Radix as raw material, adding 75% ethanol (volume percentage) of 8 times of Pulsatillae weight, then placing it in a flash extractor for extraction, extracting 2 times, each extraction time is 2min; filtering each gained extract , combined the filtrates; the remaining filter residue obtained is for use; the obtained filtrate is concentrated under reduced pressure to an extract whose specific gravity is 1.05; the concentrated filtrate is extracted with petroleum ether, extracted twice, and the petroleum ether liquid is discarded after extraction, and the lower layer of water is volatilized Remove the petroleum ether, concentrate the resulting solution at 50°C to a thick paste with a relative density of 1.20, and dry under reduced pressure to obtain the crude product of Pulsatilla grandis total saponins;

[0037] b. Evaporate the remain...

Embodiment 2

[0040] The Psyllium pulsatillae extract of the present invention is obtained by the following extraction methods:

[0041] a, take Pulsatillae Radix as raw material, add 85% ethanol (volume percentage) of 10 times of Pulsatillae weight, then place in a flash extractor to extract, extract 2 times, each extraction time is 1min; filter the extracted solution obtained each time , combined the filtrates; the remaining filter residue obtained is for use; the obtained filtrate is concentrated under reduced pressure to an extract with a specific gravity of 1.10; the concentrated filtrate is extracted with petroleum ether for 2 times, and the petroleum ether liquid is discarded after extraction, and the lower layer of water is volatilized Remove petroleum ether, concentrate the resulting solution at 60°C to a thick paste with a relative density of 1.15, and dry under reduced pressure to obtain crude Pulsatilla saponins;

[0042] b. Distill the ethanol in the remaining filter residue to...

Embodiment 3

[0045] The Psyllium pulsatillae extract of the present invention is obtained by the following extraction methods:

[0046] a, taking Pulsatillae Radix as raw material, adding 50% ethanol (volume percentage) of 6 times of Pulsatillae weight, then placing it in a flash extractor for extraction, extracting 3 times, each extraction time is 1min; filtering each gained extract , combined the filtrates; the remaining filter residue obtained is for use; the obtained filtrate is concentrated under reduced pressure to an extract with a specific gravity of 1.08; the concentrated filtrate is extracted with petroleum ether, extracted twice, and the petroleum ether liquid is discarded after extraction, and the lower layer of water is volatilized Remove the petroleum ether, concentrate the resulting solution at 55°C to a thick paste with a relative density of 1.30, and dry under reduced pressure to obtain the crude product of Pulsatilla grandis total saponins;

[0047] b. Distill the ethanol...

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Abstract

The invention discloses a pulsatilla extract and its application in the preparation of medicines for preventing and treating pulmonary fibrosis. In the present invention, Pulsatilla grandis is used as a raw material, and ethanol is added first for extraction, and the obtained extract is concentrated to an extract, and then extracted, concentrated and dried in sequence to obtain total saponins of Pulsatilla pulsatillae; after extraction, distilled water is added to the remaining filter residue for decoction and extraction, and the obtained extraction The solution is concentrated to extract, and then treated to obtain Pulsatilla polysaccharides; the total saponins and polysaccharides of Pulsatillae are mixed evenly to obtain Pulsatilla extract. It has been verified by experiments that Pulsatilla extract can prevent the formation and development of pulmonary fibrosis by inhibiting the proliferation of pulmonary fibroblasts and the transformation of alveolar epithelial cells into mesenchymal cells, so that it can be used in the preparation of drugs for the prevention and treatment of pulmonary fibrosis. application.

Description

1. Technical field: [0001] The invention relates to the technical field of medicine, in particular to a Pulsatilla pulsatilla extract and its application in the preparation of medicines for preventing and treating pulmonary fibrosis. 2. Background technology: [0002] Pulmonary fibrosis is a malignant disease that seriously threatens human health and life. The current drugs for the treatment of pulmonary fibrosis mainly include glucocorticoids, immunosuppressants and cytotoxic drugs. A small number of patients treated with glucocorticoids showed certain curative effect, but there were no complete or sustained remissions, serious side effects, uncertain long-term efficacy and other problems restricted the long-term application of these drugs. Improving the efficacy of drugs has always been the goal pursued by the majority of medical workers. With the deepening of research on the pathogenesis of pulmonary fibrosis, it has been confirmed that the excessive accumulation of col...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/71A61P11/00
Inventor 冯素香李建生刘富岗王蒙蒙罗珊
Owner HENAN UNIV OF CHINESE MEDICINE
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