A kind of Cortex Moutan extract and its application in the preparation of medicines for preventing and treating pulmonary fibrosis

A Cortex Moutan extract and the technology of Cortex Moutan are applied in the field of medicine and can solve the problems of pulmonary fibrosis and the like that there is no effective part of Cortex Moutan

Active Publication Date: 2018-03-02
HENAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, up to now, there is no relevant research report on the prevention and treatment of pulmonary fibrosis by Moutan cortex extract, effective parts and active ingredients.

Method used

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  • A kind of Cortex Moutan extract and its application in the preparation of medicines for preventing and treating pulmonary fibrosis
  • A kind of Cortex Moutan extract and its application in the preparation of medicines for preventing and treating pulmonary fibrosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Cortex Moutan extract of the present invention is extracted by the following method:

[0045] a. Take Moutan Cortex as raw material, add pectinase aqueous solution accounting for 10 times the weight of Moutan Cortex raw material, then place it in a flash extractor, and extract at room temperature for 3 minutes; add hydrochloric acid to the extracted medicinal material and the solution to adjust the obtained extraction The pH value of the solution was adjusted to 4.5, and after adjustment, the water bath was heated to 45°C for enzymolysis, and the enzymolysis was carried out for 2 hours to obtain the enzymolysis solution;

[0046] B, adopt the steam distillation method to collect the distillate accounting for 1 / 3 of the total weight of the enzymolysis solution, the gained distillate is refrigerated and placed for 24 hours at 4°C, and filtered under this condition, the gained crystal is paeonol (paeonol) Phenol purity ≥ 90%);

[0047] c. The remaining extract and dregs a...

Embodiment 2

[0052] Cortex Moutan extract of the present invention is extracted by the following method:

[0053] a. Take Moutan Cortex as raw material, add pectinase aqueous solution accounting for 15 times the weight of Moutan Cortex raw material, then place it in a flash extractor, and extract at room temperature for 2 minutes; add sulfuric acid to the extracted medicinal material and solution to adjust the obtained extraction The pH value of the solution was adjusted to 4.0, and after adjustment, the water bath was heated to 40°C for enzymolysis, and the enzymolysis was carried out for 1.5 hours to obtain the enzymolysis solution;

[0054] B, adopt the steam distillation method to collect the distillate accounting for 1 / 2 of the total weight of the enzymolysis solution, the gained distillate is refrigerated and placed for 24 hours at 4°C, and filtered under this condition, the gained crystal is paeonol (paeonol) Phenol purity ≥ 90%);

[0055] c. The remaining extract and dregs after d...

Embodiment 3

[0060] Cortex Moutan extract of the present invention is extracted by the following method:

[0061] a. Take Moutan Cortex as raw material, add pectinase aqueous solution accounting for 6 times the weight of Moutan Cortex raw material, then place it in a flash extractor, and extract at room temperature for 5 minutes; add sulfuric acid to the extracted medicinal material and solution to adjust the obtained extraction The pH value of the solution is adjusted to 3.8, and after adjustment, the water bath is heated to 60°C for enzymolysis, and the enzymolysis is carried out for 1 hour to obtain the enzymolysis solution;

[0062] B, adopt the steam distillation method to collect the distillate accounting for 1 / 4 of the total weight of the enzymolysis solution, and the gained distillate is refrigerated and placed at 4°C for 24 hours, and filtered under this condition, the gained crystal is paeonol (paeonol) Phenol purity ≥ 90%);

[0063] c. The remaining extract and dregs after dist...

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Abstract

The invention discloses an extract of Cortex Moutan and its application in preparing medicines for preventing and treating pulmonary fibrosis. Firstly extract the Cortex Moutan, adjust the pH value after extraction, heat enzymolysis; adopt steam distillation to collect the distillate after enzymolysis, place it, let stand and filter to obtain crystalline paeonol; filter the remaining extract and dregs, The dregs are set aside for use; the filtrate is concentrated under reduced pressure and deproteinized, and ethanol is added to stand still, and the ethanol solution is separated and collected for use, and the precipitate is washed to obtain polysaccharides of Moutan Cortex; Concentrate and purify under reduced pressure to obtain total glycosides of Cortex Moutan; finally mix paeonol, polysaccharides and total glycosides to obtain Cortex Moutan extract. It has been proved by experiments that Moutan cortex extract can effectively inhibit the epithelial-mesenchymal transition of alveolar epithelial cells and the activation of pulmonary fibroblasts, thereby inhibiting the formation and development of pulmonary fibrosis, making it a new role in the preparation of drugs for the prevention and treatment of pulmonary fibrosis. use.

Description

1. Technical field: [0001] The invention relates to the technical field of medicine, in particular to an extract of Cortex Moutan and its use in preparing medicines for preventing and treating pulmonary fibrosis. 2. Background technology: [0002] Pulmonary fibrosis is a malignant disease that seriously threatens human health and life. The average survival time of pulmonary fibrosis is 3 years after diagnosis, or 5 years after the onset of clinical symptoms. In the terminal stage of pulmonary fibrosis, lung transplantation is the only effective treatment. However, the lack of donors and high medical expenses limit the application of lung transplantation. Improving the efficacy of drugs has always been the goal pursued by medical workers. With the deepening of research on the pathogenesis of pulmonary fibrosis, it has been confirmed that the excessive accumulation of collagen, elastic fibers and protein sugars in the extracellular matrix (ECM) is its characteristic histopath...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/71A61P11/00
Inventor 李建生余海滨沈俊岭任周新李俊凯
Owner HENAN UNIV OF CHINESE MEDICINE
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