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Application of flavonoids compounds in preparation of T lymphocyte subsets regulating drug

A technology of lymphocytes and cell subsets, applied in the field of medicine, can solve the problem that the mechanism of anti-inflammatory action is not clear.

Inactive Publication Date: 2015-11-11
GENERAL HOSPITAL OF TIANJIN MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Despite such a wide range of biological effects, the anti-inflammatory mechanism of these substances has not yet been clarified. In recent years, studies have shown that some flavonoids may exert their anti-inflammatory biological effects through the NF-κB signal transduction pathway

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  • Application of flavonoids compounds in preparation of T lymphocyte subsets regulating drug
  • Application of flavonoids compounds in preparation of T lymphocyte subsets regulating drug
  • Application of flavonoids compounds in preparation of T lymphocyte subsets regulating drug

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Embodiment Construction

[0058] Specific embodiments of the present invention will be described in detail below. In order to avoid too many unnecessary details, well-known structures or functions will not be described in detail in the following embodiments.

[0059] Approximate language used in the following examples is for quantitative representations, indicating that certain variations in quantities are permissible without altering essential function. Accordingly, values ​​modified by language such as "about", "approximately" and the like are not limited to the exact value itself. In some embodiments, "about" means that the corrected value is allowed to vary within the range of plus or minus ten percent (10%), for example, "about 100" means any value between 90 and 110. Furthermore, in the expression "about the first value to the second value", both values ​​of the first value and the second value are corrected approximately at the same time. In some cases, the language of approximation may relate...

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Abstract

The invention provides an application of flavonoids compounds in the preparation of a T lymphocyte subsets regulating drug. The innovative discovery of the invention is that the flavonoids compounds can regulate the proportion of T lymphocyte subsets, so that the effect of immune system is regulated, and the related pathological injury can be cured. Specifically, the proportion of a CD4+IFN-gamma+Th1 cell subset, a CD4+IL-17+Th17 cell subset and a CD4+CD3e+CD62L+ThO cell subset can be lowered, and the proportion of CD4+CD25+Fo8*p3+Treg cell subset is increased. Chrysin can maintain the integrity of the blood-retinal barrier of an EAU mouse, inhibit the macrophage infiltration, and inhibit the intraocular inflammation. At the same time, the expression quantity of retinas STAT1, STAT3 and phosphorylated protein is inhibited. Based on new properties of the flavonoids, the flavonoids can be applied for curing a plurality of diseases with the effect of proportional imbalance of T cell subsets.

Description

technical field [0001] The invention relates to the technical field of medicine, and further relates to the new medical application of substances, in particular to the application of flavonoids in the preparation of drugs for regulating T lymphocyte subsets. Background technique [0002] Flavonoids generally refer to a series of compounds with two aromatic rings connected to each other through a three-carbon chain. In a narrow sense, it refers to a series of compounds whose basic core has a 2-phenylchromone structure. Studies in the prior art have shown that flavonoids or flavonols in a narrow sense have a wide range of biological activities, including anti-tumor, anti-inflammatory, anti-allergic, anti-oxidative stress and cardiovascular protection, etc. Treatment of some inflammatory diseases. Despite such a wide range of biological effects, the anti-inflammatory mechanism of these substances has not yet been clarified. In recent years, studies have shown that some flavono...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P37/06A61P29/00A61P27/02
Inventor 颜华孟祥达方思捷刘媛媛郑芳张竹红
Owner GENERAL HOSPITAL OF TIANJIN MEDICAL UNIV
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