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A kind of arsenic chelated immune complex and its preparation method and application

An immune complex and chelation-type technology, applied in the field of detection of circulating immune complexes, can solve problems such as lack of disease-specific value

Inactive Publication Date: 2017-01-18
广东腾湃医疗股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these methods can only detect non-specific circulating immune complexes, most of which can only be used as indicators of disease activity and lack disease-specific value

Method used

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  • A kind of arsenic chelated immune complex and its preparation method and application
  • A kind of arsenic chelated immune complex and its preparation method and application
  • A kind of arsenic chelated immune complex and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0167] In this example, ITCBE was purchased from Japan Tongren Chemical Research Institute, item number M030;

[0168] The following borate buffer solution, its molar concentration is 0.01M, the preparation method example: Weigh 0.31g boric acid and dissolve it in 400mLddH 2 In O, use 0.1mol / L NaOH aqueous solution to adjust the pH to 9.0, and set the volume to 500mL, to obtain;

[0169] The following EDTA-NaHCO 3 Solution preparation method example: Take 1.86g EDTA·2H 2 O and 16.8 g NaHCO 3 , dissolved in 900mLddH 2 In O, adjust the pH to 8.0 with 1.0M NaOH and dilute to 1000mL, autoclave, and store at 25±2°C;

[0170] The following dialysis bags had a molecular weight cut-off of 14000 and were purchased from Bioshop Inc; the dialysis bags were processed as follows: Place the dialysis bag in 500 mL volume of EDTA-NaHCO 3 solution, boil for 10min; discard EDTA-NaHCO 3 solution with ddH 2 Rinse with O, then boil with 500mL 5mmol / L EDTA for 10min; 2 O cleaning, adding a ...

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Abstract

The invention provides an arsenic-chelated immune compound, and a preparation method and an application of the arsenic-chelated immune compound. The arsenic-chelated immune compound is one of the following compounds: a compound formed from an immune compound combined with arsenic ions, or a compound formed from carrier protein combined with arsenic and an antibody specifically binding to the carrier protein, or a compound formed from immune globulin combined with arsenic and carrier protein. The arsenic-chelated immune compound is an immune compound with relative specificity. Whether the arsenic-chelated immune compound is contained in serum of people in an area and the content of the compound are detected, so that the arsenic pollution degree in the area is indirectly reflected.

Description

technical field [0001] The invention relates to the detection of circulating immune complexes, in particular to an arsenic chelated immune complex. Background technique [0002] Immune complexes (IC) are the product of antigen-antibody binding. According to the definition of the National Committee for Scientific and Technical Terms, IC refers to the complex formed by the combination of antibody and soluble antigen. It is divided into two categories, one is the fixed immune complexes in the tissue, and the other is the immune complexes that are free in the blood and become circulating immune complexes (circulating immune complexes, CIC). The clearance of immune complexes depends to a large extent on the size of CIC, antibody type, relative concentration of antigen and antibody, etc. Only in a few cases, immune complexes precipitate and cause tissue damage and disease. The occurrence of various diseases is closely related to the deposition of immune complexes, such as systemi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K14/00G01N33/96G01N33/68
CPCG01N33/53G01N33/531
Inventor 张积仁阳帆董欣敏吴婧蔡睿孙遥赵乙木
Owner 广东腾湃医疗股份有限公司
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