The invention discloses an arsenic chelating type immune compound. The arsenic chelating type immune compound is selected from one of the following compounds: the compound formed by binding arsenic ions and the immune compound; or, the compound formed from the arsenic ions bound with vector protein and an antibody specifically bound with the vector protein; or, the compound formed by binding the arsenic ions with immune globulin and then binding with the vector protein. The invention also discloses a preparation method of the arsenic chelating type immune compound with excellent effect. The preparation method comprises the following steps of S1, preparing a chelating agent solution; S2, preparing a vector protein solution; S3, stirring and staying overnight; S4, dialyzing; S5, adding the arsenic ions; S6, recycling the waste solution; S7, specifically binding. The preparation method has the characteristics that the application range is broader, the cost is reduced, the dialyzing rate is increased, the preparation cycle is shortened, the energy-saving and environment-friendly effects are realized, and the chemical pollution is avoided; the market competitiveness is larger.