Ages-degrading agent and use thereof

A decomposing agent and decomposing enzyme technology, which is applied in the direction of medical preparations containing active ingredients, anti-toxic agents, anti-inflammatory agents, etc., can solve the problem of enzyme activity reduction, and achieve the effects of disease prevention, excellent productivity, and excellent safety

Inactive Publication Date: 2015-12-09
ARKRAY INC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the enzymatic activity of these enzymes decreases with age, and therefore, the possibility of treating and preventing the above-mentioned diseases, the aging of the above-mentioned tissues, and the decrease in the function of tissues by enhancing the activities of the above-mentioned enzymes has been placed

Method used

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  • Ages-degrading agent and use thereof
  • Ages-degrading agent and use thereof
  • Ages-degrading agent and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0109] In this example, 1-phenyl-1,2-propanediol (PPD) was used as an index to evaluate the AGEs decomposition activity produced by plant extracts.

[0110] (1) Preparation of plant extraction samples

[0111] Prepare plant samples as indicated below. Among the above-mentioned plant samples, the plants were cut according to the Table of Food Components 2012 (published by Women's Nutrition University), and dried at 65° C. 20 hours. Then, the dried plant sample and the plant sample subjected to the above-mentioned drying treatment were pulverized by a small pulverizer (LM-PLUS, Osaka Chemical Co., Ltd.) to be powdered. 3.75 g of the obtained powder sample was suspended in 150 ml of 80°C distilled water, and extracted in a water bath set at 80°C for 1 hour. Then, centrifugation was performed to obtain a supernatant. These supernatants were used as extraction samples.

[0112] Groundnuts: unheated seeds

[0113] Rosemary: Leaves and Stems

[0114] Polygonum: young buds

[...

Embodiment 2

[0138] In this example, extracts of plants were evaluated for antioxidant activity.

[0139] (1) Preparation of plant extraction samples

[0140] From the plants shown in Table 2 below, powder samples were prepared in the same manner as in Example 1 above, and extracted samples were prepared.

[0141] [Table 2]

[0142]

[0143] (2) Determination of antioxidant capacity of extracted samples

[0144] For the measurement of the antioxidant capacity, ARKRAY's Spotchem (trademark) i-Pack Oxystress Test (trademark) was used. The reaction solution containing a thiocyanate compound and iron (III) ions forms a red complex due to the two, so the reaction solution turns red. For this reaction solution, when it is further made to coexist with reducing substances, the iron (III) ions constituting the above-mentioned complex are reduced to iron (II) ions by utilizing the reducing action (antioxidant action) of the above-mentioned reducing substances, so the reaction The red color of...

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Abstract

The present invention provides a novel AGEs-degrading agent. The AGEs-degrading agent of the present invention contains at least one kind of plant extract obtained from a plant selected from the group consisting of peanut, rosemary, knotweed, leaf lettuce, sweet basil, thyme, spearmint, lemon balm, shiso, and rhubarb.

Description

technical field [0001] The present invention relates to AGEs decomposer and its use. Background technique [0002] Oxidation reactions and glycation reactions in living organisms are known to adversely affect cells and tissues. In particular, proteins undergoing oxidation or glycation reactions, that is, oxidized proteins or glycated proteins, are produced and accumulated leading to diseases such as diabetes complications, Alzheimer's disease, cataracts, arteriosclerosis, and aging and function reduction of tissues such as skin. Therefore, the above-mentioned oxidized protein and the above-mentioned glycated protein are called damage proteins. In particular, accumulation of end products AGEs (advanced glycation end products: advanced glycation end products) produced by a non-enzymatic addition reaction of sugars to proteins is regarded as a problem. [0003] Usually, these harmful proteins are decomposed and removed by proteolytic enzymes such as proteasome and oxidized pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/708A61K36/704A61K36/535A61K36/534A61K36/53A61K36/48A61K36/28A61K36/185A61K36/282A61K36/61A61K36/81A61K36/8962A61K36/9068A61K36/9066A61K36/67A61K36/54A61P39/06A61P3/10A61P25/28A61P27/12A61P9/10A61P19/10A61P19/02
CPCA61K8/97A61Q19/08A61K8/9761A61K8/9789A61K8/9794A61P17/00A61P19/02A61P19/10A61P25/28A61P27/12A61P29/00A61P39/06A61P43/00A61P9/10A61P3/10A61K36/28A61K36/48A61K36/53A61K36/704A61K36/534A61K36/535A61K36/708A61K2300/00A61K36/61A61K36/81A61K36/79A61K36/88A61K36/14A61K36/9068A61K36/185A61K36/23A61K36/54A61K45/06
Inventor 八木雅之米井嘉一河合博成所司原雅子
Owner ARKRAY INC
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