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Application of long non-coding RNA uc.48+ small interfering RNA to preparation of medicine for treating DM complicating neuropathic pain

A neuropathic pain, ribonucleic acid technology, used in nervous system diseases, drug combinations, non-central analgesics, etc., can solve the problem of not much research on long non-coding RNAs

Active Publication Date: 2015-12-09
NANCHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, breakthroughs have been made in the research of non-coding RNAs (such as microRNA, siRNA and piRNA) with a length of less than 50 nucleotides, but there are not many studies on functional long non-coding RNAs

Method used

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  • Application of long non-coding RNA uc.48+ small interfering RNA to preparation of medicine for treating DM complicating neuropathic pain
  • Application of long non-coding RNA uc.48+ small interfering RNA to preparation of medicine for treating DM complicating neuropathic pain
  • Application of long non-coding RNA uc.48+ small interfering RNA to preparation of medicine for treating DM complicating neuropathic pain

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019]Oral or injectable long non-coding ribonucleic acid uc.48+ small interfering RNA preparations suitable for the treatment of diabetic neuropathic pain were prepared by methods known in the art.

Embodiment 2

[0021] Using methods known in the art, an oral or injectable long non-coding ribonucleic acid uc.48+ small interfering RNA preparation suitable for the treatment of diabetes complicated with nerve damage-related diseases is prepared.

Embodiment 3

[0023] Using a method known in the art, an oral or injectable long non-coding ribonucleic acid uc.48+ small interfering RNA preparation suitable for the treatment of diabetes complicated with sensory neuroinflammation-related diseases is prepared.

[0024] In conclusion, the long non-coding RNA uc.48+ small interfering RNA can be used for the prevention and treatment of the above-mentioned diseases by oral administration, injection, lozenge or other topical or systemic dosage forms.

[0025] In order to better understand the essence of the present invention, the following uses long non-coding ribonucleic acid uc.48+ small interfering ribonucleic acid to P2X 3 Experiments and results of research on the therapeutic effect of receptor-mediated related diseases to demonstrate the use of long non-coding RNA uc.48+ small interfering RNA.

[0026] 1. Materials and methods.

[0027] 1. Animals and groupings.

[0028] Healthy Sprague-Dawley (SD) rats were provided by the Laboratory A...

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Abstract

The invention provides application of long non-coding RNA (Ribonucleic Acid) uc.48+ small interfering RNA to preparation of medicine for treating DM (Diabetes Mellitus) complicating neuropathic pain. Experiments prove that NONRATT021972 small interfering RNA can reduce the expression of a dorsal root ganglion neuron P2X3 receptor, can reduce the generation of a DM rat dorsal root ganglion cell inflammatory factor-TNF-alpha (Tumor Necrosis Factor-alpha), can inhibit the nociceptive information transmission of the dorsal root ganglion, can reduce the nociception stimulation of the nerve injury and inflammatory substances, can reduce the pain behavior of a rat with the type 2 DM neuropathic pain, and can be applied to the preparation of medicine for treating DM complicating neuropathic pain, DM complicating nerve injury relevant diseases and DM complicating nerve injury sensory nerve inflammatory diseases.

Description

technical field [0001] The present invention relates to the field of invention of pharmaceutical use for diabetes complicated with neuropathic pain. Background technique [0002] Diabetes Mellitus (DM) is a group of metabolic clinical syndromes. With the development of society and the improvement of people's living standards, the prevalence of diabetes is increasing year by year, and the prevalence of diabetes in developed countries has reached 3%-7%. It has become the fourth priority disease after cancer, AIDS, and cardiovascular and cerebrovascular diseases, and has become the fifth leading cause of death in the world. Diabetes is divided into type 1 (insulin dependent) and type 2 (non-insulin dependent) diabetes. It is estimated that one in six people worldwide is at risk of developing complications from diabetes. Type 2 diabetes accounts for more than 90% of the diabetic population in my country, which seriously affects people's health and social development. Diabetic...

Claims

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Application Information

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IPC IPC(8): A61K48/00A61K31/713A61P3/10A61P25/00A61P29/00
Inventor 梁尚栋王寿玉吴炳邹丽芳刘双梅高云李桂林吴琴张熙应末凤
Owner NANCHANG UNIV
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