A kind of aryl-alkyne compound and its preparation method and application

A technology for compounds and synthetic methods, applied in chemical instruments and methods, organic chemistry, instruments, etc., can solve problems such as peripheral nervous system damage, environmental pollution, gold loss, etc., achieving high sensitivity and selectivity, simple detection methods, low cost effect
CN105294677BInactive Publication Date: 2017-04-12HEBEI UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
HEBEI UNIVERSITY
Publication Date
2017-04-12
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses an aryl-alkyne compound (2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinolin-8-yl 3-phenylpropiolate) as well as preparation and application of the compound. A synthesis method of the aryl-alkyne compound comprises the following steps: under the condition that the temperature is 0 DEG C, dissolving 8-hydroxyjulolidine and phenylpropiolic acid into dichloromethane and adding a condensing agent EDC (Ethylene Dichloride) and an alkali DMAP (Dimethylaminopyridine) and stirring and reacting at 20 to 30 DEG C for 5 to 8 hours; after the reaction, concentrating; carrying out silica-gel column chromatography on concentrated liquid; then eluting, decompressing and evaporating to remove the solvent to obtain a product. The compound can be used as a reagent for detecting the concentration of trivalent gold ions by a fluorescent spectrometry. Firstly, the aryl-alkyne compound provided by the invention has a simple preparation method and low cost and is prepared from the 8-hydroxyjulolidine and the phenylpropiolic acid through a one-step reaction; secondly, the compound can be used as a trivalent gold detection reagent and has high sensitivity and selectivity on Au<3+>; a detection result is not interfered by other metal ions; a detection method is simple and a detection process is carried out in a water phase and can be realized with the help of a fluorescence spectrophotometer.
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Description

technical field

[0001] The present invention relates to heterocyclic compounds and Au 3+ The detection and analysis technology specifically relates to an aryl-alkyne compound, its preparation method and its application in the detection of trivalent gold ions. Background technique

[0002] Gold is a transition metal with special physical and chemical properties. It plays a very important role in many aspects of material science, including catalysis, medicine, food, electronics industry and other manufacturing industries. In recent years, gold and gold Ionic salts are mostly used in medical and chemical fields. Because gold has good biological adaptability, it is also widely used in biology. Gold ions play a particularly prominent role in the treatment of rheumatism. It can be used as an inhibitor of macrophages and polymorphonuclear leukocytes, but its ion salts (such as hydrochloride) can cause damage to people's liver, kidneys and peripheral nervous system. Therefore, it...

Claims

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