42 results about "Alkyne Compound" patented technology

This application discloses a negative curvature polycyclic aromatic hydrocarbon containing an eight-membered ring, its synthesis method, and its application, belonging to the field of organic synthesis. The synthesis method uses a haloacenaphthene derivative as a starting material. First, a tetrahalogenated key intermediate containing an eight-membered ring is constructed via a titanium tetrachloride-catalyzed cyclization tetramerization reaction. Subsequently, this intermediate undergoes a cyclization coupling reaction with an alkyne compound in the presence of a palladium catalyst, silver salt, and phosphine ligand to generate a negative curvature polycyclic aromatic hydrocarbon containing an eight-membered ring. The synthesis method of this application avoids multi-step precursor synthesis, resulting in a concise process. It allows for the flexible introduction of functional groups such as trifluoromethyl and silyl groups, improving the solubility and processability of the material. The obtained product exhibits a non-planar configuration, a narrow optical band gap, and excellent electron transport properties, making it suitable for applications... n Applications include semiconductors, chiral optoelectronic materials, and nano-carbon materials.

The invention discloses a tetra-coordinated boron-oxygen heterocyclic compound and a preparation method thereof, and belongs to the technical field of pharmaceutical and chemical intermediates and related chemistry. The method comprises the following steps: by taking a bis (pentafluorophenyl) borane dimethyl sulfide complex [(C6F5) 2BHSMe2] as a boron source, firstly carrying out hydroboronation reaction on the bis (pentafluorophenyl) borane dimethyl sulfide complex [(C6F5) 2BHSMe2] and an eneyne compound to generate a three-coordination alkenyl boron dienophile intermediate in situ, and then carrying out reverse electron demand Diels-Alder reaction on the three-coordination alkenyl boron dienophile intermediate and an acetylenic ketone compound to synthesize a series of tetra-coordination boron-oxygen heterocyclic compounds. The method has the advantages of mild reaction conditions, good selectivity, high yield, wide substrate application range, environmental friendliness, simplicity and convenience in operation and the like, opens up a new way for synthesis of the tetra-coordinated organoboron compound, and has higher application value and social and economic benefits.

The invention relates to a method for decarbonylation alkynylation of ketone, which comprises the following step: in an inert solvent, under the action of a metal catalyst and a ligand, carrying out decarbonylation-reduction coupling reaction on a ketone compound and alkynyl chloride to obtain an alkyne compound. The alkyne is synthesized under the strategy of nickel catalysis, and the method has the advantages of easily available raw materials, simple operation and mild conditions, has very good theoretical guidance significance and practical application value, and conforms to the sustainable green chemistry concept.

This invention provides general formula (1): R 1 C≡CR 2 [R 1 and R 2 The same or different, indicating the method of manufacturing fluoroalkyne compounds represented by fluorine atoms or fluoroalkyl groups, includes making general formula (2): R in the presence of an ether solvent. 1 CHX 1 CFX 2 R 2 [R 1 and R 2 Same as above; X 1 and X 2 In the middle, X 1 It is a fluorine atom and X 2 It is a hydrogen atom, or X 1 It is a hydrogen atom and X 2 The process of dehydrofluorinating a fluoroalkane compound represented by a fluorine atom [ ] includes a step of performing a hydrogen defluorination reaction, and satisfies at least one of the following (I) or (II): (I) the fluoroalkyl group is a fluoroalkyl group having 1 to 4 carbon atoms; (II) the ether solvent is a chain ether compound; and the hydrogen defluorination reaction is carried out in the presence of a solvent containing the chain ether and a base containing an alkali metal and / or alkaline earth metal hydroxide and / or alkoxide. By this manufacturing method, fluoroalkane compounds can be efficiently synthesized from fluoroalkane compounds.

The invention belongs to the field of organic synthesis, and particularly relates to a synthesis method of terminal alkyne. The method comprises the following steps: mixing a 2-methylpyridine compound as shown in a formula 1 and N, N-dimethylformamide as shown in a formula 2 with an organic solvent (cyclopentyl methyl ether or tetrahydrofuran) in the presence of lithium bis (trimethylsilyl) amide, cesium fluoride, perfluorobutyl sulfonyl fluoride and 1, 8-diazabicyclo [5.4. 0] undec-7-ene, and reacting to synthesize the terminal alkyne as shown in a formula 3. The raw materials adopted by the invention are common chemicals in the market. The method is wide in application range, common terminal alkyne compounds can be synthesized, reaction substrates can be adjusted according to needs, and a series of terminal alkyne derivatives can be synthesized. Certain support is provided for research in the fields of medicine, material science and the like. The invention provides biological activity of an iso-terminal alkyne compound on oomycetes plant pathogens and a determination method of the iso-terminal alkyne compound.

The invention provides an olefine aldehyde intermediate and a synthetic method thereof, and a synthetic method of conopomorpha sinensis sex pheromone, and belongs to the field of compound synthesis. According to the synthesis method of the olefine aldehyde intermediate, provided by the invention, 1, 5-pentanediol is taken as a raw material, and the high-yield olefine aldehyde intermediate is obtained through transesterification, first oxidation reaction, Wittig reaction and Sagsa oxidation reaction; the yield of the olefine aldehyde intermediate can be further improved by limiting a catalytic system and an auxiliary agent of the Sagsa oxidation reaction. Results of the embodiment show that the synthesis method provided by the invention does not adopt alkyne compounds, the yield of the product in the Sagassa oxidation reaction stage can reach 81%, the total yield of the obtained olefine aldehyde intermediate can reach 48.5%, the sex pheromone of conopomorpha sinensis prepared by adopting the olefine aldehyde intermediate can reach 39.8%, and the yield is high.

The present invention provides a method for producing perfluoroalkyne compounds by isomerization reaction of perfluoroalkadiene compounds, which enables the production of perfluoroalkyne compounds in high yield. It also provides a composition having a high content of perfluoroalkyne compounds and a low content of other organic compounds with 5 carbon atoms. [Solution] A method for producing a perfluoroalkyne compound, comprising the step of reacting a perfluoroalkadiene compound in the presence of a fluorinated aluminum chloride-containing catalyst to obtain a perfluoroalkyne compound, wherein the fluorinated aluminum chloride-containing catalyst is obtained by removing at least a portion of the by-products from a product obtained by reacting aluminum chloride in the presence of a hydrochlorofluorocarbon.

The application discloses a synthesis method of 1,4-disubstituted 1,2,3-triazole and belongs to the technical field of organic synthesis. In an air atmosphere, an alkyne compound and an azide compound are subjected to a mechanical activation induced cycloaddition reaction in the presence of a copper catalyst, a 4-mercapto-1,2,3-triazole ligand and a promoter, and 1,4-disubstituted 1,2,3-triazole is obtained. The method has the following advantages: (1) toxic and volatile organic solvents can be avoided; (2) inert gas atmosphere can be avoided; (3) the reaction time is short; (4) the catalyst loading is low; (5) the yield is high; and (6) the functional group tolerance range is wide.

The present invention relates to a polymerizable composition comprising at least one polythiol, at least one polyisocyanate or polyisothiocyanate, and at least one polymerizable compound of formula (I) wherein R1 and R2 represent a hydrogen atom, a substituted or unsubstituted alkyl group, a (hetero) aryl group, or R1 and R2 together form a divalent group of formula-R1-R2-, wherein-R1-R2-represents a substituted or unsubstituted alkylene group, Z represents OH, SH, NH2 or NHR4, where R4 represents a substituted or unsubstituted alkyl group or a (hetero) aryl group, and R3 represents a hydrogen atom, a substituted or unsubstituted alkyl group, a (hetero) aryl group, or a CR '1R' 2Z 'group, where R' 1, R '2 and Z'are as defined by R1, R2 and Z.

The invention discloses a benzofuro [3, 2-d] pyrazolo [1, 5-a] pyrimidine compound as well as a synthesis method and application thereof, and relates to the technical field of organic synthesis and medicinal chemistry, the synthesis method of the compound comprises the following steps: in the presence of a catalyst and alkali, mixing a salicylaldehyde compound, a terminal alkyne compound and an alpha-aminoazole compound in a solvent for reaction, and separating to obtain the benzofuro [3, 2-d] pyrazolo [1, 5-a] pyrimidine compound. The benzofuro [3, 2-d] pyrazolo [1, 5-a] pyrimidine compound is obtained through the reaction. The furo [3, 2-d] pyrimidine compound is prepared by taking a salicylaldehyde compound, a terminal alkyne compound and an alpha-aminoazole compound as initial raw materials through a one-pot method, the reaction condition is mild, the raw materials are cheap and easy to obtain, the operation is simple and convenient, the production cost can be greatly reduced, and the production efficiency is improved; the furo [3, 2-d] pyrimidine compound has remarkable antifungal activity on plant pathogenic fungi, and can be applied to inhibition of fungi such as apple black beetle fungus and rhizoctonia solani.

To obtain a halogenated alkene compound and a halogenated alkyne compound in high conversion and high selectivity.SOLUTION: Any one of the following methods (1) to (4) is employed: (1) CX1X2X3CHX4CFHCX5X6X7 wherein X1, X2, X3, X4, X5, X6, and X7 are identical or different and are halogen atoms. (2) CX1X2X3CX4 = CHCX5X6X7 [X1, X2, X3, X4, X5, X6, and X7 are as defined above]. (3) CHX8A1CHX9A2 wherein A1 and A2 are each independently a halogen atom or a perfluoroalkyl group. X8 and X9 are identical to or different from each other and each represent a halogen atom; (4) CX8A1 = CHA2 [wherein A1, A2 and X8 are as defined above] is subjected to a dehydrohalogenation reaction in the gas phase in the presence of a catalyst. Is subjected to a dehydrohalogenation reaction in the presence of a catalyst.SELECTED DRAWING: None

The application discloses a transition metal-free method for preparing o-iodophenyl acetylide, which uses o-dihalobenzene and terminal alkyne as raw materials, and reacts to obtain o-iodophenyl acetylide in the presence of alkali metal hydride; preferably, the reaction is carried out in a solvent. Specifically, the alkali metal hydride is added into the solvent, then the terminal alkyne compound is added, stirred for 5 min, and then the o-dihalobenzene is added, and the reaction is carried out at 0-60 DEG C to obtain the alkylation product o-iodophenyl acetylide. The method is simple in operation, mild in reaction condition, and can be easily scaled up, and does not need any metal additive or anhydrous condition.

Disclosed herein are compositions and methods for the selective photocatalytic reduction of an alkyne compound to an alkene compound (e.g., acetylene to ethylene).

The application belongs to the field of organic synthesis, and particularly relates to a synthesis method of TMS protected alkyne. An alkyl amide derivative shown in formula 1 and N,N-dimethylformamide shown in formula 2 are mixed with an organic solvent (tetrahydrofuran) in the presence of a strong base (lithium bis(trimethylsilyl)amide) and an activating agent (diethyl chlorophosphate), and a reaction is performed to synthesize TMS protected alkyne shown in formula 3. The raw materials used in the application are common chemicals on the market. The application has a wide range of applications, and not only can common TMS protected alkyne compounds be synthesized, but also a series of TMS protected alkyne derivatives can be synthesized according to the need of adjusting the reaction substrate. This provides certain support for the research in the fields of medicine, material science and the like.

The invention discloses an application of an asymmetric alkynyl compound in an electrolyte and the electrolyte thereof, the structure of the asymmetric alkynyl compound is as shown in the following formula (I): when the asymmetric alkynyl compound is applied to the electrolyte, not only can the low impedance performance of a battery be improved, but also the high temperature performance of the battery can be improved.

The present invention is intended to provide a compound useful to analyze a vitamin D compound. The present invention provides an alkyne compound represented by Formula (I):where in Formula (I), A is a linear carbon chain having an alkynyl group at an end and having a vinyl group at another end; X1 is CH or 13CH; X2 is CHY, CDY, 13CHY, 13CDY, CO, 13CO, C18O, or 13C18O; m is an integer from 1 to 4; when m is 2 or more, X2s are identical or different; Y is H, D, NH2, 15NH2, OH, 18OH, SH, OR, O(CO)R, OSO3H, OSO3Na, or a sugar substituent; when Formula (I) contains two or more Ys, Ys are identical or different; R is an alcohol protective group, an alkyl group, an alkenyl group, or an aryl group; X3 is C or 13C; and at least one selected from the group consisting of X1, X2(s), and X3 is modified with a stable isotope D, 13C, 18O, or 15N.

The invention belongs to the technical field of organic synthesis, and particularly relates to a method for directly synthesizing fumaric acid and succinic acid derivatives from CO2. According to the invention, the aryne compound is taken as a raw material, and fumaric acid and succinic acid derivatives are synthesized at high conversion rate and high selectivity under an electrochemical condition in a CO2 atmosphere, so that the application of the fumaric acid and succinic acid derivatives in the aspect of derivatization of bioactive molecules is expanded.

The present invention provides a method for producing purified fluoroalkyne compounds, a fluorinated adsorbent, and a method for producing the same, which enable the suppression of the generation of organic compounds other than the fluoroalkyne compound that originate from the fluoroalkyne compound during the dehydration treatment of the fluoroalkyne compound. [Solution] A method for producing a purified fluoroalkyne compound, comprising the step of performing a dehydration treatment on a water-containing fluoroalkyne compound using a fluorinated adsorbent to obtain a purified fluoroalkyne compound, wherein the fluoroalkyne compound is represented by formula 1. TIFF2026110074000013.tif12114 (In the formula, R 1 and R 2 Each of these independently represents a hydrogen atom, a fluorine atom, or a fluoroalkyl group, R 1 and R 2 At least one of them represents the fluoroalkyl group.

The invention relates to a polymerizable composition comprising a) at least one polyiso (thio) cyanate and at least one prepolymer having thiol end groups, obtained from the reaction of a mixture of at least one polythiol and at least one polymerizable compound of formula (I), or b) a prepolymer of at least one polythiol and at least one isocyanate or isothiocyanate end group having the formula-NCX, where X is O or S, obtained from the reaction of a mixture of at least one polyiso (thio) cyanate and at least one polymerizable compound having the formula (I), where R1 and R2 represent a hydrogen atom, a substituted or unsubstituted alkyl group, a (hetero) aryl group, or R1 and R2 together form a divalent group having the formula-R1-R2-, where-R1-R2-represents a substituted or unsubstituted alkylene group, Z represents OH, SH, NH2 or NHR4, where R4 represents a substituted or unsubstituted alkyl or (hetero) aryl group, and R3 represents a hydrogen atom, a substituted or unsubstituted alkyl group, (hetero) aryl group, or a CR '1R' 2Z 'group, where R' 1, R '2 and Z' are defined as R1, R2 and Z. (Formula I))

The application discloses a chemical synthesis method of 5-phenyl-5-aroyl-1,3-dioxane compound. The method is one-pot reaction of alkyne compound and paraformaldehyde under catalysis of boron trifluoride ether, to generate 5-phenyl-5-aroyl-1,3-dioxane compound. The method has the advantages of mild reaction condition, simple operation, easy-to-obtain raw material, excellent compatibility of substrate functional groups, high reaction yield, low reaction cost and the like, and has high application value.

The application discloses a preparation method of a gamma-pyrone compound, which comprises the following steps: using a dibromo enone compound with a chemical structure general formula as shown in formula (I) and a non-terminal alkyne compound with a structure general formula as shown in formula (II) as raw materials, reacting under the action of a catalyst and an additive in an organic solvent at 100-120 DEG C for 10-24 hours to obtain a gamma-pyrone compound with a structure general formula as shown in formula (III). The dibromo enone compound and the non-terminal alkyne compound used in the method have the advantages of simple synthesis process operation, easy preparation, high conversion rate and wide substrate application range; the gamma-pyrone compound is successfully prepared by using the dibromo enone compound and the non-terminal alkyne compound as raw materials, and has the characteristics of simple and easy operation, low cost, green environmental protection, high atom economy and high yield. Since the gamma-pyrone compound is widely distributed in biological and pharmaceutical active molecules, the gamma-pyrone compound has wide application prospects.

The invention discloses a green synthesis method of a 1, 2-diketone compound, and belongs to the technical field of organic synthesis. According to the invention, an alkyne compound is used as a raw material, 2, 2, 6, 6-tetramethylpiperidine-1-oxygen radical (TEMPO) is used as a catalyst, oxygen in air is used as an oxidant, tetrahydrofuran and water are used as solvents, and a reaction is carried out to obtain the 1, 2-diketone compound. The method has the remarkable advantages of mild reaction conditions, greenness and environmental protection, efficient and practical catalyst selection, good reaction efficiency and controllability, convenience in product separation and purification, high yield, wide substrate universality and the like, conforms to the characteristic of green chemistry, and is a synthesis method of the 1, 2-diketone compound, which is very suitable for industrialization.

To obtain a halogenated alkene compound and a halogenated alkyne compound at a high conversion rate and selectivity.SOLUTION: Any of the following methods (1)-(4) is employed: (1) a halogenated butane compound represented by CX1X2X3CHX4CFHCX5X6X7 [where X1, X2, X3, X4, X5, X6 and X7 are identical to or different from each other, and are halogen atoms] is subjected to a dehydrofluorination reaction; (2) a halogenated butene compound represented by CX1X2X3CX4=CHCX5X6X7 [where X1, X2, X3, X4, X5, X6 and X7 are the same as above] is subjected to a dehydrohalogenation reaction; (3) a halogenated alkane compound represented by CHX8A1CHX9A2 [where A1 and A2 are fluorine atoms or perfluoroalkyl groups, and X8 and X9 are identical to or different from each other, and are halogen atoms] is subjected to a dehydrohalogenation reaction in a vapor phase in the presence of a catalyst; and (4) a halogenated alkene compound represented by CX8A1=CHA2 [where A1, A2, and X8 are the same as above] is subjected to a dehydrohalogenation reaction in the presence of a catalyst.SELECTED DRAWING: None

The present invention relates to a polymerizable composition containing at least one polythiol, at least one polyisocyanate or polyisothiocyanate, and at least one polymerizable compound of formula (I), wherein R 1 and R 2 represent a hydrogen atom, a substituted or unsubstituted alkyl group, a (hetero)aryl group, or R 1 and R 2 together form a divalent group of the formula -R 1 -R 2 -, -R 1 -R 2 - represents a substituted or unsubstituted alkylene group, Z represents OH, SH, NH2, or NHR 4 where R 4 represents a substituted or unsubstituted alkyl group or a (hetero)aryl group, R3 represents a hydrogen atom, a substituted or unsubstituted alkyl group, a (hetero)aryl group, or a group of CR’ 1 R’ 2 Z’, and R’ 1 , R’ 2 , and Z’ are as defined for R 1 , R 2 , and Z. JPEG2026525351000028.jpg21162

The invention discloses a method for synthesizing an axially chiral gamma-carbazolone derivative, and belongs to the field of organic chemistry. An indole-3-amide compound 1 and an alkyne compound 2 are used as raw materials, and in the presence of a catalyst Mn (OAc) 3.2 H2O, the axially chiral gamma-carbazolone derivative is obtained through cobalt-catalyzed C-H activation / cyclization. The method is mild in reaction condition and environment-friendly, the axially chiral gamma-carbazolone derivative can be obtained with high yield and high enantioselectivity, and a simple and effective synthesis way is provided for the axially chiral gamma-carbazolone derivative.

The invention discloses a fluorine-containing polyester compound with a low refractive index and a preparation method and application thereof, and belongs to the technical field of high polymer chemistry, a binary fluorine-containing alkyne compound and a binary fluorine-containing alcohol compound are used as monomers, and the fluorine-containing polyester compound can be prepared through a polymerization reaction. And further introducing a polyol compound into the reaction system, and branching the space structure of the fluorine-containing polyester compound to obtain the fluorine-containing polyester compound with the branched structure. The fluorine-containing polyester compound and the fluorine-containing polyester compound with the branched structure are low in refractive index, the preparation method is simple and mild in condition, the fluorine-containing polyester compound shows wide application prospects in the fields of optical devices and display, and the fluorine-containing polyester compound also has excellent thermal stability and good solubility and is convenient to process and form.

The invention discloses a preparation method of an NHC-boronized alkyne compound, which comprises the following specific preparation process: taking an ethynyl benzoxazolinone compound and an N-heterocyclic carbene borane compound as reaction raw materials, 4-CzIPN as a photocatalyst, Cs2CO3 as alkali and acetonitrile as a solvent, and reacting under blue light LED irradiation and nitrogen atmosphere to obtain the NHC-boronized alkyne compound. And finally, the target product NHC-boronized alkyne compound is prepared. Through visible light catalysis, the reaction condition is mild, the operation is simple and convenient, N-heterocyclic carbene borane which is easy to synthesize is used as a boron source, ethynyl benzoxazolinone is used as an alkynylation reagent, and various NHC-boronized alkyne compounds can be efficiently synthesized.

The application discloses a synthesis method of a (Z)-1-aryl sulfide-2-phenol ether-4-aryl-trisubstituted-1-butene-3-alkyne compound, which comprises two-step room temperature reactions: firstly, in a dry reaction container, 1,3-di-alkynyl triiodide reagent (I), a phenol compound, a base reagent and an organic solvent are mixed, and stirring reaction is carried out at room temperature until the starting material is completely consumed, and the solvent is removed by concentration under reduced pressure; then, a sulfenol compound, a copper catalyst and an organic solvent are added into the concentrated residue, and stirring reaction is carried out at room temperature until completion, and the target product (II) is obtained through post-treatment. The molar ratio of the 1,3-di-alkynyl triiodide reagent (I), the phenol compound and the sulfenol compound is 1:1.05:(1.1-1.3); the copper catalyst is selected from one of cuprous iodide, cuprous chloride and tetraethylammonium copper tetrafluoroborate, and the copper catalyst is preferably tetraethylammonium copper tetrafluoroborate; and the organic solvent is selected from acetonitrile, 1,2-dichloroethane and the like, and the total amount of the organic solvent added is 0.1 mmol in terms of the amount of substance of the reagent shown in formula (I). The method has mild reaction conditions, simple operation and can efficiently prepare the target compound.

The invention relates to the technical field of adhesives, in particular to a high-strength recoverable cross-linking type epoxy adhesive and a preparation method and application thereof.The cross-linking type epoxy adhesive is prepared from, by weight, 40-60 parts of epoxy resin, 0-40 parts of epoxy reactive diluent, 40-100 parts of amine curing agent, 10-100 parts of activated alkyne compound, 20-40 parts of solvent and 0-130 parts of lignin. Wherein the activated alkyne compound comprises one or more of a bifunctional / trifunctional ester group activated alkyne compound and a bifunctional carbonyl group activated alkyne compound. The adhesive prepared by the invention not only has excellent bonding strength and toughness, but also can be recycled through thermal excitation dynamic bond exchange, and can effectively eliminate internal stress generated by volume shrinkage or mismatching of thermal expansion coefficients in the curing process; and the dimensional stability and durability of a bonding interface under long-term use or environment change are obviously improved.

The application belongs to the field of constructing a lead compound library in medical research, and particularly relates to a method for synthesizing an On-DNA alkenyl phosphine oxide compound through photocatalysis. The method comprises a reaction step of forming an On-DNA alkenyl phosphine oxide compound by reacting a DNA-alkyne compound with a phosphine oxide compound under the action of light and an organic photocatalyst. The method for constructing an alkenyl phosphine oxide compound in the application is still significantly superior to the prior art in substrate adaptability, conversion rate, convenience and mildness of reaction conditions, cost and the like. The wide substrate adaptability is mainly reflected in that the DNA-alkyne includes a phenyl DNA-terminal alkyne, a DNA-heterocyclic terminal alkyne, a fatty DNA-terminal alkyne and an internal alkyne, and the phosphine oxide includes various structures such as aryl phosphine oxide of methoxy, methyl and fluorine.