65 results about "Alkyne Compound" patented technology

This application discloses a negative curvature polycyclic aromatic hydrocarbon containing an eight-membered ring, its synthesis method, and its application, belonging to the field of organic synthesis. The synthesis method uses a haloacenaphthene derivative as a starting material. First, a tetrahalogenated key intermediate containing an eight-membered ring is constructed via a titanium tetrachloride-catalyzed cyclization tetramerization reaction. Subsequently, this intermediate undergoes a cyclization coupling reaction with an alkyne compound in the presence of a palladium catalyst, silver salt, and phosphine ligand to generate a negative curvature polycyclic aromatic hydrocarbon containing an eight-membered ring. The synthesis method of this application avoids multi-step precursor synthesis, resulting in a concise process. It allows for the flexible introduction of functional groups such as trifluoromethyl and silyl groups, improving the solubility and processability of the material. The obtained product exhibits a non-planar configuration, a narrow optical band gap, and excellent electron transport properties, making it suitable for applications... n Applications include semiconductors, chiral optoelectronic materials, and nano-carbon materials.

The application discloses a kind of all-substituted pyrrole compounds, the raw material alkyne compound of the application has structural diversity with isonitrile compound, can be used to synthesize different types and structures of all-substituted pyrrole compounds;Reaction raw material diphenylacetylene and its same type substrate compared with the raw material of the reaction reported by predecessors, have the advantages of simple and easy to obtain, stable nature;All-substituted pyrrole compounds have good diversity and functional group tolerance, so it has wide application;Further modification is carried out to different substitution sites on the heterocyclic skeleton of all-substituted pyrrole compounds, and intermediates of chemical products and drug structures can be obtained;The target product of the application takes pyrrole as the key mother nucleus, while amide and other unsaturated groups are introduced on the ring, and the structure has potential pharmacological activity;Cheap transition metal nickel is used as catalyst;The yield of the application is good.

The invention discloses a continuous flow preparation method of polysubstituted propargyl alcohol, which uses a microtube continuous flow reaction device and comprises the following specific steps: simultaneously conveying acetylene gas or terminal alkyne compound and an organic alkali solution into a mixer for premixing; simultaneously conveying the keto-carbonyl substrate and the flowing-out reaction liquid to a reactor to carry out an alkyne hydrogenation reaction; and carrying out gas-liquid separation on the outflowing reaction liquid, and rectifying in a rectifying tower to obtain a target propargyl alcohol product. According to the method for continuously preparing the polysubstituted propargyl alcohol by using the continuous flow reaction system, full mixing of reaction materials of each reaction unit and accurate control of the reaction can be realized by regulating and controlling pipeline parameters, the automation degree is greatly improved, the manual operation is reduced, the energy consumption cost is reduced, and the method is suitable for industrial production.

The invention discloses a tetra-coordinated boron-oxygen heterocyclic compound and a preparation method thereof, and belongs to the technical field of pharmaceutical and chemical intermediates and related chemistry. The method comprises the following steps: by taking a bis (pentafluorophenyl) borane dimethyl sulfide complex [(C6F5) 2BHSMe2] as a boron source, firstly carrying out hydroboronation reaction on the bis (pentafluorophenyl) borane dimethyl sulfide complex [(C6F5) 2BHSMe2] and an eneyne compound to generate a three-coordination alkenyl boron dienophile intermediate in situ, and then carrying out reverse electron demand Diels-Alder reaction on the three-coordination alkenyl boron dienophile intermediate and an acetylenic ketone compound to synthesize a series of tetra-coordination boron-oxygen heterocyclic compounds. The method has the advantages of mild reaction conditions, good selectivity, high yield, wide substrate application range, environmental friendliness, simplicity and convenience in operation and the like, opens up a new way for synthesis of the tetra-coordinated organoboron compound, and has higher application value and social and economic benefits.

The invention provides a synthesis method of styrene compounds, and belongs to the technical field of organic synthesis reaction. The method disclosed by the invention comprises the step of reacting a phenolic compound with an alkyne compound to synthesize the styrene compound in a protective atmosphere and an alkaline solvent environment under the action of a rhodium catalyst and an instantaneous positioning group. In addition, after the reaction is finished, the obtained styrene compound is subjected to column chromatography separation and purification. Compared with a traditional synthesis method, the method is simple to operate, raw materials are easy to obtain, functional groups are good in compatibility, and a substrate is wide in application range.

The invention discloses a method for synthesizing alpha-alkenyl boron ester by Markov hydroboration of terminal alkyne, which comprises the following steps of: under the protection of inert gas, carrying out hydroboration reaction on a terminal alkyne compound shown as a formula I and pinacolborane which are used as raw materials and an amide oxazoline cobalt complex which is used as a catalyst in an organic solvent under the action of alkali; the alpha-alkenyl boron ester compound as shown in the formula II is prepared. The invention provides the cobalt complex catalyst with high efficiency, high selectivity and high substrate compatibility and the method, the reaction condition is mild, the operation is simple and convenient, the atom economy is high, and the product yield and the selectivity of the product are improved. When the catalyst is used for a gram-level amplification reaction, a crude product can be purified in a recrystallization or distillation manner, so that the purification step is greatly simplified, and the technical problems of difficulty in separation and low yield in a reaction amplification process of synthesizing alpha-alkenyl boron ester by Markov hydroboration of terminal alkyne in the prior art are solved; and the method has a relatively high industrial application value.

The invention relates to a method for decarbonylation alkynylation of ketone, which comprises the following step: in an inert solvent, under the action of a metal catalyst and a ligand, carrying out decarbonylation-reduction coupling reaction on a ketone compound and alkynyl chloride to obtain an alkyne compound. The alkyne is synthesized under the strategy of nickel catalysis, and the method has the advantages of easily available raw materials, simple operation and mild conditions, has very good theoretical guidance significance and practical application value, and conforms to the sustainable green chemistry concept.

This invention provides general formula (1): R 1 C≡CR 2 [R 1 and R 2 The same or different, indicating the method of manufacturing fluoroalkyne compounds represented by fluorine atoms or fluoroalkyl groups, includes making general formula (2): R in the presence of an ether solvent. 1 CHX 1 CFX 2 R 2 [R 1 and R 2 Same as above; X 1 and X 2 In the middle, X 1 It is a fluorine atom and X 2 It is a hydrogen atom, or X 1 It is a hydrogen atom and X 2 The process of dehydrofluorinating a fluoroalkane compound represented by a fluorine atom [ ] includes a step of performing a hydrogen defluorination reaction, and satisfies at least one of the following (I) or (II): (I) the fluoroalkyl group is a fluoroalkyl group having 1 to 4 carbon atoms; (II) the ether solvent is a chain ether compound; and the hydrogen defluorination reaction is carried out in the presence of a solvent containing the chain ether and a base containing an alkali metal and / or alkaline earth metal hydroxide and / or alkoxide. By this manufacturing method, fluoroalkane compounds can be efficiently synthesized from fluoroalkane compounds.

The invention belongs to the field of organic synthesis, and particularly relates to a synthesis method of terminal alkyne. The method comprises the following steps: mixing a 2-methylpyridine compound as shown in a formula 1 and N, N-dimethylformamide as shown in a formula 2 with an organic solvent (cyclopentyl methyl ether or tetrahydrofuran) in the presence of lithium bis (trimethylsilyl) amide, cesium fluoride, perfluorobutyl sulfonyl fluoride and 1, 8-diazabicyclo [5.4. 0] undec-7-ene, and reacting to synthesize the terminal alkyne as shown in a formula 3. The raw materials adopted by the invention are common chemicals in the market. The method is wide in application range, common terminal alkyne compounds can be synthesized, reaction substrates can be adjusted according to needs, and a series of terminal alkyne derivatives can be synthesized. Certain support is provided for research in the fields of medicine, material science and the like. The invention provides biological activity of an iso-terminal alkyne compound on oomycetes plant pathogens and a determination method of the iso-terminal alkyne compound.

The invention provides an olefine aldehyde intermediate and a synthetic method thereof, and a synthetic method of conopomorpha sinensis sex pheromone, and belongs to the field of compound synthesis. According to the synthesis method of the olefine aldehyde intermediate, provided by the invention, 1, 5-pentanediol is taken as a raw material, and the high-yield olefine aldehyde intermediate is obtained through transesterification, first oxidation reaction, Wittig reaction and Sagsa oxidation reaction; the yield of the olefine aldehyde intermediate can be further improved by limiting a catalytic system and an auxiliary agent of the Sagsa oxidation reaction. Results of the embodiment show that the synthesis method provided by the invention does not adopt alkyne compounds, the yield of the product in the Sagassa oxidation reaction stage can reach 81%, the total yield of the obtained olefine aldehyde intermediate can reach 48.5%, the sex pheromone of conopomorpha sinensis prepared by adopting the olefine aldehyde intermediate can reach 39.8%, and the yield is high.

The present invention provides a method for producing perfluoroalkyne compounds by isomerization reaction of perfluoroalkadiene compounds, which enables the production of perfluoroalkyne compounds in high yield. It also provides a composition having a high content of perfluoroalkyne compounds and a low content of other organic compounds with 5 carbon atoms. [Solution] A method for producing a perfluoroalkyne compound, comprising the step of reacting a perfluoroalkadiene compound in the presence of a fluorinated aluminum chloride-containing catalyst to obtain a perfluoroalkyne compound, wherein the fluorinated aluminum chloride-containing catalyst is obtained by removing at least a portion of the by-products from a product obtained by reacting aluminum chloride in the presence of a hydrochlorofluorocarbon.

The application discloses a synthesis method of 1,4-disubstituted 1,2,3-triazole and belongs to the technical field of organic synthesis. In an air atmosphere, an alkyne compound and an azide compound are subjected to a mechanical activation induced cycloaddition reaction in the presence of a copper catalyst, a 4-mercapto-1,2,3-triazole ligand and a promoter, and 1,4-disubstituted 1,2,3-triazole is obtained. The method has the following advantages: (1) toxic and volatile organic solvents can be avoided; (2) inert gas atmosphere can be avoided; (3) the reaction time is short; (4) the catalyst loading is low; (5) the yield is high; and (6) the functional group tolerance range is wide.

The present invention relates to a polymerizable composition comprising at least one polythiol, at least one polyisocyanate or polyisothiocyanate, and at least one polymerizable compound of formula (I) wherein R1 and R2 represent a hydrogen atom, a substituted or unsubstituted alkyl group, a (hetero) aryl group, or R1 and R2 together form a divalent group of formula-R1-R2-, wherein-R1-R2-represents a substituted or unsubstituted alkylene group, Z represents OH, SH, NH2 or NHR4, where R4 represents a substituted or unsubstituted alkyl group or a (hetero) aryl group, and R3 represents a hydrogen atom, a substituted or unsubstituted alkyl group, a (hetero) aryl group, or a CR '1R' 2Z 'group, where R' 1, R '2 and Z'are as defined by R1, R2 and Z.

The invention belongs to the technical field of organic chemistry, and particularly relates to a dehydroabietic acid 1, 2, 3-triazole derivative as well as a preparation method and application thereof. The preparation method comprises the following steps: reacting dehydroabietic acid in a first organic solvent under the action of a reducing agent to obtain a compound 2 with reduced carboxyl; reacting the compound 2 with p-toluenesulfonyl chloride under the action of an alkali solution to obtain a hydroxyl-protected compound 3; in a second organic solvent, reacting the compound 3 with sodium azide under a high-temperature condition to obtain an azide compound 4; and reacting the compound 4 with a copper salt and an alkyne compound in a polar solvent of alkali to obtain a target compound. The dehydroabietic acid derivative with high biological activity is synthesized, raw materials are cheap and easy to obtain, reaction conditions are mild, aftertreatment is simple, the yield is high, a virulent solvent is not used in the synthesis process, the green chemical requirement is met, high pressure or a special catalyst is not needed, and large-scale production can be achieved in conventional equipment.

The application relates to application of a polyene alkyne compound in preparation of a medicine for preventing and / or treating pulmonary fibrosis. The specific polyene alkyne compound has obvious inhibiting collagen deposition effect on TGF-beta 1 induced human embryo lung fibroblasts, does not show cytotoxicity, has good anti-pulmonary fibrosis activity, and can be used for preparing the medicine for preventing and / or treating pulmonary fibrosis.

The invention discloses a benzofuro [3, 2-d] pyrazolo [1, 5-a] pyrimidine compound as well as a synthesis method and application thereof, and relates to the technical field of organic synthesis and medicinal chemistry, the synthesis method of the compound comprises the following steps: in the presence of a catalyst and alkali, mixing a salicylaldehyde compound, a terminal alkyne compound and an alpha-aminoazole compound in a solvent for reaction, and separating to obtain the benzofuro [3, 2-d] pyrazolo [1, 5-a] pyrimidine compound. The benzofuro [3, 2-d] pyrazolo [1, 5-a] pyrimidine compound is obtained through the reaction. The furo [3, 2-d] pyrimidine compound is prepared by taking a salicylaldehyde compound, a terminal alkyne compound and an alpha-aminoazole compound as initial raw materials through a one-pot method, the reaction condition is mild, the raw materials are cheap and easy to obtain, the operation is simple and convenient, the production cost can be greatly reduced, and the production efficiency is improved; the furo [3, 2-d] pyrimidine compound has remarkable antifungal activity on plant pathogenic fungi, and can be applied to inhibition of fungi such as apple black beetle fungus and rhizoctonia solani.

The present disclosure relates to a solid propellant composition for curing azide-alkyne triazole, which cures a propellant by forming a polymer network using triazole groups formed by a reaction between an azide compound and an alkyne compound, and a method for preparing a solid propellant using same.

This invention belongs to the field of quinoxaline compound synthesis and discloses a quinoxaline compound molecule and a preparation method thereof. The preparation method comprises: using a cobalt salt as a catalyst, mixing an alkyne compound, an o-phenylenediamine compound, an oxidant, and an organic solvent, and heating to obtain a quinoxaline drug molecule. The invention has the advantages of mild reaction conditions, good substrate universality, high synthesis yield, and the use of an inexpensive and readily available catalyst.

To obtain a halogenated alkene compound and a halogenated alkyne compound in high conversion and high selectivity.SOLUTION: Any one of the following methods (1) to (4) is employed: (1) CX1X2X3CHX4CFHCX5X6X7 wherein X1, X2, X3, X4, X5, X6, and X7 are identical or different and are halogen atoms. (2) CX1X2X3CX4 = CHCX5X6X7 [X1, X2, X3, X4, X5, X6, and X7 are as defined above]. (3) CHX8A1CHX9A2 wherein A1 and A2 are each independently a halogen atom or a perfluoroalkyl group. X8 and X9 are identical to or different from each other and each represent a halogen atom; (4) CX8A1 = CHA2 [wherein A1, A2 and X8 are as defined above] is subjected to a dehydrohalogenation reaction in the gas phase in the presence of a catalyst. Is subjected to a dehydrohalogenation reaction in the presence of a catalyst.SELECTED DRAWING: None

The invention provides a Z-type olefin synthesis method by using polyoxometalate molybdate as a photocatalyst, which comprises the following steps of: catalyzing a P (O)-H compound to initiate a phosphine free radical by using Lindequist polyoxomolybdate [N (C4H9) 4] 2 [Mo6O19] as the photocatalyst so as to realize addition of the phosphine free radical and an aryl alkyne compound, and providing various Z-type olefins with medium yields by using tert-butyl hydroperoxide as an oxidant. According to the method, direct phosphorylation reaction of the aryl alkyne compound can be realized under the mild condition without transition metal, and a series of Z-alkenyl phosphine oxide compounds can be synthesized. The used catalyst has good stability and reusability, and also shows satisfactory photocatalytic activity under the irradiation of sunlight. The reaction method has the advantages of being mild in reaction condition, easy to separate and purify, environment-friendly, high in chemical selectivity and stereoselectivity, simple and convenient to operate, wide in application range, good in yield and the like, and the gram-level reaction shows the potential application value of the reaction method.

The invention discloses a method for preparing a polydeuterated phenylpropionic acid compound from alkyne. The method comprises the following step: carrying out an illumination reaction on a mixed reaction system at least containing an alkyne compound, heavy water, oxalate and a photosensitive catalyst, so as to prepare the polydeuterated phenylpropionic acid compound. The method for preparing the polydeuterated phenylpropionic acid compound from the alkyne has the advantages of being good in substrate compatibility, high in yield, short in reaction time, safe, stable, easy to operate and the like, and meanwhile the prepared polydeuterated phenylpropionic acid compound plays an important role in the fields of biology, medicine, materials and the like.

The application discloses a transition metal-free method for preparing o-iodophenyl acetylide, which uses o-dihalobenzene and terminal alkyne as raw materials, and reacts to obtain o-iodophenyl acetylide in the presence of alkali metal hydride; preferably, the reaction is carried out in a solvent. Specifically, the alkali metal hydride is added into the solvent, then the terminal alkyne compound is added, stirred for 5 min, and then the o-dihalobenzene is added, and the reaction is carried out at 0-60 DEG C to obtain the alkylation product o-iodophenyl acetylide. The method is simple in operation, mild in reaction condition, and can be easily scaled up, and does not need any metal additive or anhydrous condition.

Disclosed herein are compositions and methods for the selective photocatalytic reduction of an alkyne compound to an alkene compound (e.g., acetylene to ethylene).

The application belongs to the field of organic synthesis, and particularly relates to a synthesis method of TMS protected alkyne. An alkyl amide derivative shown in formula 1 and N,N-dimethylformamide shown in formula 2 are mixed with an organic solvent (tetrahydrofuran) in the presence of a strong base (lithium bis(trimethylsilyl)amide) and an activating agent (diethyl chlorophosphate), and a reaction is performed to synthesize TMS protected alkyne shown in formula 3. The raw materials used in the application are common chemicals on the market. The application has a wide range of applications, and not only can common TMS protected alkyne compounds be synthesized, but also a series of TMS protected alkyne derivatives can be synthesized according to the need of adjusting the reaction substrate. This provides certain support for the research in the fields of medicine, material science and the like.

The invention discloses an application of an asymmetric alkynyl compound in an electrolyte and the electrolyte thereof, the structure of the asymmetric alkynyl compound is as shown in the following formula (I): when the asymmetric alkynyl compound is applied to the electrolyte, not only can the low impedance performance of a battery be improved, but also the high temperature performance of the battery can be improved.

The present invention is intended to provide a compound useful to analyze a vitamin D compound. The present invention provides an alkyne compound represented by Formula (I):where in Formula (I), A is a linear carbon chain having an alkynyl group at an end and having a vinyl group at another end; X1 is CH or 13CH; X2 is CHY, CDY, 13CHY, 13CDY, CO, 13CO, C18O, or 13C18O; m is an integer from 1 to 4; when m is 2 or more, X2s are identical or different; Y is H, D, NH2, 15NH2, OH, 18OH, SH, OR, O(CO)R, OSO3H, OSO3Na, or a sugar substituent; when Formula (I) contains two or more Ys, Ys are identical or different; R is an alcohol protective group, an alkyl group, an alkenyl group, or an aryl group; X3 is C or 13C; and at least one selected from the group consisting of X1, X2(s), and X3 is modified with a stable isotope D, 13C, 18O, or 15N.

The invention belongs to the technical field of organic synthesis, and particularly relates to a method for directly synthesizing fumaric acid and succinic acid derivatives from CO2. According to the invention, the aryne compound is taken as a raw material, and fumaric acid and succinic acid derivatives are synthesized at high conversion rate and high selectivity under an electrochemical condition in a CO2 atmosphere, so that the application of the fumaric acid and succinic acid derivatives in the aspect of derivatization of bioactive molecules is expanded.

The present invention provides a method for producing purified fluoroalkyne compounds, a fluorinated adsorbent, and a method for producing the same, which enable the suppression of the generation of organic compounds other than the fluoroalkyne compound that originate from the fluoroalkyne compound during the dehydration treatment of the fluoroalkyne compound. [Solution] A method for producing a purified fluoroalkyne compound, comprising the step of performing a dehydration treatment on a water-containing fluoroalkyne compound using a fluorinated adsorbent to obtain a purified fluoroalkyne compound, wherein the fluoroalkyne compound is represented by formula 1. TIFF2026110074000013.tif12114 (In the formula, R 1 and R 2 Each of these independently represents a hydrogen atom, a fluorine atom, or a fluoroalkyl group, R 1 and R 2 At least one of them represents the fluoroalkyl group.

The invention relates to a polymerizable composition comprising a) at least one polyiso (thio) cyanate and at least one prepolymer having thiol end groups, obtained from the reaction of a mixture of at least one polythiol and at least one polymerizable compound of formula (I), or b) a prepolymer of at least one polythiol and at least one isocyanate or isothiocyanate end group having the formula-NCX, where X is O or S, obtained from the reaction of a mixture of at least one polyiso (thio) cyanate and at least one polymerizable compound having the formula (I), where R1 and R2 represent a hydrogen atom, a substituted or unsubstituted alkyl group, a (hetero) aryl group, or R1 and R2 together form a divalent group having the formula-R1-R2-, where-R1-R2-represents a substituted or unsubstituted alkylene group, Z represents OH, SH, NH2 or NHR4, where R4 represents a substituted or unsubstituted alkyl or (hetero) aryl group, and R3 represents a hydrogen atom, a substituted or unsubstituted alkyl group, (hetero) aryl group, or a CR '1R' 2Z 'group, where R' 1, R '2 and Z' are defined as R1, R2 and Z. (Formula I))

The application provides a method for catalytically synthesizing (E)-beta-thio vinyl sulfone compounds by using organic semiconductor carbon nitride, and relates to the technical field of organic synthesis. The synthesis method provided by the application uses thiosulfonate and alkyne compounds as reaction substrates, uses graphite phase carbon nitride g-C3N4 prepared by urea thermal polycondensation as a heterogeneous photocatalyst, and makes the atom transfer radical addition reaction occur under the condition of an organic solvent and light to obtain the (E)-beta-thio vinyl sulfone compound. The application provides a new path for the synthesis of (E)-beta-thio vinyl sulfone compounds, and the yield is high. The synthesis method of the application uses organic semiconductor carbon nitride as a photocatalyst, and has the advantages of easy availability of raw materials, simple process, mild reaction conditions, green environmental protection and the like. The synthesis method of the application has wide substrate applicability, and can be used to synthesize various (E)-beta-thio vinyl sulfone compounds by using different substrates.