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Orally disintegrating tablet containing Istradefylline and preparation method thereof

The technology of oral disintegrating tablet and istraphylline is applied in the field of istraphylline oral disintegrating tablet and its preparation, and flavor correction of bitter and numb medicine, and can solve the problems of poor oral compliance and slow onset of ordinary tablet.

Inactive Publication Date: 2016-05-04
BEIJING VENTUREPHARM BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] For Parkinson's patients, ordinary tablets are less orally compliant and have a slower onset of action

Method used

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  • Orally disintegrating tablet containing Istradefylline and preparation method thereof
  • Orally disintegrating tablet containing Istradefylline and preparation method thereof
  • Orally disintegrating tablet containing Istradefylline and preparation method thereof

Examples

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Effect test

Embodiment Construction

[0025] The following examples are used to further illustrate the present invention, to further understand an orally disintegrating tablet containing istradefylline and its preparation method, but the present invention is not limited thereto.

[0026] The tablets compressed in the following examples and comparative examples, unless otherwise specified, were all compressed with the same type of tablet press, and the hardness was controlled within the range of 20-40N.

[0027] 1. Test

[0028] Table 1

[0029]

[0030] Preparation Process:

[0031] (1) In Example 1, grind istradefylline to a particle size of less than 10 μm; in Example 2, co-powder istradefylline and lactose at a ratio of 1:1 to a particle size of less than 10-20 μm; in Example 3, grind istradefylline To particle diameter 20 ~ 30 μm; Comparative Example 1 did not carry out micronization treatment;

[0032] (2) Mix the API with lactose, microcrystalline cellulose, crospovidone, and aspartame;

[0033] (3...

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Abstract

The invention discloses an orally disintegrating tablet containing Istradefylline and a preparation method thereof. The tablet contains a water-soluble filler, a binder, a disintegrating agent, a lubricant, and an odor mask. A solid dispersion technology is employed to improve the taste. The tablet has the characteristics of good taste, good oral compliance, rapid onset, and is applicable to the treatment of Parkinson's disease. The invention also provides a preparation method. The method has simple process and low cost, and belongs to the medical technical fields of medical science and pharmacy.

Description

technical field [0001] The invention relates to an orally disintegrating istradefylline tablet for anti-Parkinson's disease and a preparation method thereof, and particularly provides a method for correcting the taste of bitter and numb drugs, the active ingredient of which is istradefylline (Istradefylline). The process is simple and controllable, has stable dissolution characteristics of active ingredients, has quick onset and good compliance after oral administration, and belongs to the technical field of medicine. Background technique [0002] Parkinson's disease is a progressive and incurable disease. Although there are drugs that can slow down the symptoms of the disease and slow down the course of the disease, there is still a lack of effective preventive drugs. The current treatment of this disease is mainly based on dopamine replacement therapy, the most commonly used are dopamine-mimicking drugs, including levodopa and direct or indirect dopamine receptor agonists...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/522A61K47/38A61P25/16
CPCA61K9/0056A61K9/2054A61K31/522
Inventor 李自丹张庭
Owner BEIJING VENTUREPHARM BIOTECH
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