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Reagent for prognosis of breast cancer

A prognostic judgment, breast cancer technology, applied in the direction of microbial determination/inspection, biochemical equipment and methods, etc., can solve the problem of difficult to find the effect of miRNA in prognostic judgment, and achieve the effect of avoiding treatment and improving the quality of life

Active Publication Date: 2016-05-18
王辉云
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AI Technical Summary

Problems solved by technology

However, it is well known that there are many kinds of miRNAs in tissues, and there are many individual differences, which makes it difficult to find a single or a group of miRNAs with good prognostic effects.

Method used

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  • Reagent for prognosis of breast cancer
  • Reagent for prognosis of breast cancer
  • Reagent for prognosis of breast cancer

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0019] Discovery of miRNAs related to breast cancer prognosis:

[0020] Firstly, total RNA was extracted from 422 paraffin sections of breast cancer and 31 paraffin sections of normal breast preserved in the Cancer Hospital Affiliated to Sun Yat-sen University, and the RNA concentration and quality were detected by nanodrop for later miRNA chip test. 422 patients were randomly divided into training group and test group, and their basic information is shown in Table 1. In addition, in order to further test whether miRNA molecular signatures have the same predictive ability in different populations, 161 breast cancer tissues from the First Affiliated Hospital of Guangzhou Medical University were collected to form an independent group (the basic information is shown in Table 1).

[0021] Table 1. Characteristics of clinical data of cases in training group, validation group, and independent group

[0022]

[0023]

[0024] Data are mean (standard deviation) or number (%), u...

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Abstract

The invention discloses a kit for prognosis and postoperative treatment response prediction of breast cancer. Five miRNAs (miR-205, miR-320a, miR-665, miR-188-5p and miR-198), which are obviously related to the survival prognosis of patients, are discovered by the inventor, wherein two of the miRNAs are protective and the other three miRNAs are dangerous. By virtue of the five miRNAs molecular tags, the patients are classified into patients of high risk and patients of low risk; and overall survivals of the two groups are compared based on survival analysis, discovering that a significant difference exists between the overall survivals of the high-risk group and the low-risk group (p=0.001). The reagent is effective for guiding the clinical treatment of the breast cancer and is capable of conducting appropriate adjuvant therapy on the patients of high risk in prognosis, so that the survival quality of the patients is improved; and meanwhile, unnecessary treatment on the patients of low risk can be avoided.

Description

technical field [0001] The invention relates to a kit for judging tumor prognosis and chemotherapy response, in particular to a kit for judging prognosis of breast cancer. Background technique [0002] The global incidence of breast cancer has been on the rise since the late 1970s. 1 in 8 women in the U.S. will develop breast cancer in her lifetime. China is not a country with a high incidence of breast cancer, but it should not be optimistic. In recent years, the growth rate of the incidence of breast cancer in my country is 1 to 2 percentage points higher than that of countries with a high incidence. According to the 2009 breast cancer incidence data released by the National Cancer Center and the Ministry of Health's Bureau of Disease Control and Prevention in 2012, the incidence of breast cancer in the national tumor registration area ranks first among female malignant tumors, and the incidence (crude rate) of female breast cancer is the highest in the country. The tota...

Claims

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Application Information

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IPC IPC(8): C12Q1/68
Inventor 王辉云胡婧晔
Owner 王辉云
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