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Autistic serum polypeptide marker PF4-A and application thereof

A technology for PF4-A and serum peptides, applied in peptide sources, biological testing, animal/human peptides, etc., can solve problems such as lack of quantifiable indicators

Active Publication Date: 2016-06-01
XI AN JIAOTONG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The diagnosis of the disease originated from the observation of clinical symptoms of a group of patients. Since the diagnosis of autism, the diagnostic criteria have been revised many times due to the lack of quantifiable indicators.

Method used

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  • Autistic serum polypeptide marker PF4-A and application thereof
  • Autistic serum polypeptide marker PF4-A and application thereof
  • Autistic serum polypeptide marker PF4-A and application thereof

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Embodiment Construction

[0021] The autism serum polypeptide molecule provided by the invention is a newly screened autism serum diagnostic marker, its expression has specificity, and can be applied to autism diagnosis. The present invention will be further described in detail below in conjunction with specific embodiments, which are explanations of the present invention rather than limitations.

[0022] The specific screening of the serum diagnostic markers for autism is as follows:

[0023] First, the liquid protein chip technology was used to separate and extract the serum protein peptides of children with autism and normal controls, and MALDI-TOF-MS was used to capture the protein and peptide profiles of children with autism and normal controls, and the software ClinProTools2.1 was used to compare and analyze the protein peptides of children with autism. The differences in the serum protein and polypeptide spectra of children and normal people were used to find out the scores of protein polypeptid...

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Abstract

The invention discloses an autistic serum polypeptide marker PF4-A and application thereof.The amino acid sequence of the autistic serum polypeptide marker PF4-A is shown as SEQ.ID.NO.1.The molecule is named as PF4-A and is a segment of a platelet factor 4 (PF4), and the precise molecular weight of the PF4-A is 7775 daltons.The PF4-A shows significant high expression in detection of the serum of autistic children, and the method that the PF4-A is detected through a matrix-assisted laser desorption ionization time-of-flight mass spectrometer (MALDI-TOF-MS) or the PF4 expression level is detected through an ELISA method can be taken as a detection method for the autistic serum.

Description

technical field [0001] The invention belongs to the technical field of autism detection, and relates to an autism serum polypeptide marker PF4-A and an application thereof. Background technique [0002] Autism, also known as autism spectrum disorder (Autism Spectrum Disorders, ASD), is a generalized neurodevelopmental disorder characterized by loss of social function, abnormal verbal and nonverbal communication, and stereotyped limitations of behavior and interests. 1%. Generally, the onset occurs in early childhood before the age of 3 and lasts for life. The incidence rate of boys is 4 to 6 times that of girls. Research shows that early diagnosis and screening for ASD can help increase the chances that children with autism will benefit from early intervention. However, due to the lack of biomarkers, the current screening and diagnosis of ASD is mainly based on children's behavioral characteristics and developmental history, so there is controversy, and there is an urgent ...

Claims

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Application Information

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IPC IPC(8): C07K14/47G01N33/68
CPCG01N33/6893C07K14/47G01N2333/47G01N2800/30
Inventor 黄辰杨娟宋土生
Owner XI AN JIAOTONG UNIV
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