Integrated microsphere preparation device

Abstract

The invention provides an integrated microsphere preparation device. The integrated microsphere preparation device is characterized by comprising a microsphere forming line, a microsphere post-processing tank, a connecting and transferring device and a refrigerating device, wherein the microsphere forming line is used for processing liquid materials into primary cured microspheres, the microsphere post-processing tank is used for subjecting the primary cured microspheres to further curing, temperature reversion and washing, the connecting and transferring device is used for conveying the microspheres produced by the microsphere forming line into the microsphere post-processing tank, the refrigerating device is used for subjecting the microspheres treated by the microsphere post-processing tank to filling and freeze drying, and the microsphere forming line, the microsphere post-processing tank, the connecting and transferring device and the refrigerating device are arranged in a sterile isolation hood. The integrated microsphere preparation device integrates microsphere preparation steps of forming, curing, collecting, washing and sieving previously operated by five units, so that the whole technological process can be conducted in a sterile isolator, and simplicity and convenience in sterile production are achieved; the integrated microsphere preparation device is simple and convenient to operate, safe and environment friendly, thereby meeting industrial demands.

Description

technical field [0001] The invention relates to a microsphere preparation device, in particular to a microsphere production device for the production of biomedical microsphere preparations, which is simple and convenient in operation, environmentally safe, sterile and easy to control. Background technique [0002] Since the 1980s, the market for protein and peptide drugs has grown rapidly at an annual rate of 14%-16%. At present, about 150 protein drugs have been launched, accounting for half of the total prescription drug market. Protein and polypeptide drugs are generally administered by injection, but due to their short biological half-life, frequent injections are often required, which greatly reduces patient compliance, and increases the patient's economic burden and drug risk. [0003] Microspheres are tiny spherical entities with a particle size ranging from 1-250 μm. With the development of pharmacy, microsphere preparations have been found to have the effects of ta...

AI Technical Summary

Problems solved by technology

At present, there is no physical machinery and corresponding production method suitable for the production of pharmaceutical microspheres on an industrial scale

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