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An apparatus for producing microspheres of customizable sizes efficiently

A technology of microspheres and drainage devices, which is applied in the direction of making medicines into special physical or taking form devices, heat insulation devices, manufacturing tools, etc., can solve the problems of difficulty in meeting large-scale production industrial needs and low production efficiency

Inactive Publication Date: 2019-01-15
SHANGHAI TOFFLON SCI & TECH CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this method can obtain uniform microsphere particle size, more than 90% drug encapsulation efficiency, and rarely expose the protein to the water-oil interface, but the production efficiency of this method is too low to meet the industrial needs of large-scale production

Method used

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  • An apparatus for producing microspheres of customizable sizes efficiently
  • An apparatus for producing microspheres of customizable sizes efficiently
  • An apparatus for producing microspheres of customizable sizes efficiently

Examples

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Embodiment

[0069] It should be understood that the following examples belong to a part of our ongoing research on similar devices of the present invention, are for the convenience of readers to better understand this invention, and are only used to illustrate the present invention and not limit the scope of the present invention.

[0070] Such as figure 1 As shown, the device for preparing microspheres includes an SPG membrane 14, and the solution containing microsphere-forming materials can be extruded through the SPG membrane to form microsphere droplets under the pressure of high-pressure gas; microsphere solidification column 2, microsphere droplets Settled to the bottom in the microsphere solidification column and solidified and formed by solvent extraction; microsphere collector 3, used to collect the microspheres solidified and formed; post-processing device 5, used to carry out organic solvent and organic solvent for the solidified formed microspheres Removal of other impurities...

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Abstract

A design of apparatus using which microspheres of customizable uni-sizes may be produced through a greatly simplified process. The apparatus consists a microsphere-forming unit, a microsphere rinsingunit, and a sterile hood (1) that isolates the other two unit within a sterilized cover. The microsphere-forming unit enables the processed microsphere formation, solidification and collection simultaneously. The sterile hood (1) allows the microsphere producing operation be carried out within a glove box, preventing direct contact of operator with the sterilized materials of the microspheres. Theapparatus also has a refrigerator (11) wherein the microsphere collector (3) and final product storage are placed for extracting the solvent of microsphere-forming materials and stabilizing the finalproduct, respectively.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of Chinese Invention Patent Application No. 201610260675.9 filed on April 25, 2016, which is incorporated herein by reference. technical field [0003] The present application relates to a device for efficiently preparing microspheres with controllable and uniform particle size, and the device can be widely used in the fields of pharmaceutical preparations, biotechnology, food industry, agriculture and the like. technical background [0004] Microspheres are tiny spherical entities with a particle size ranging from 1-250 μm. Polymer microspheres have great potential in the field of medical science because of their good fluidity, ease of injection, and remarkable long-acting properties. They have been extensively studied since the 1970s. The concept was first proposed from the article "Polymers for sustained release of proteins and other macromolecules" published by R. Langer and J. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61J3/00
CPCA61J3/00A61J2200/40A61J2200/72B01D2325/0283B01D2313/22B01D2313/903A61J3/06B01D63/062B01D63/16B01D2311/2642B01D2313/12B01L3/52B01L7/04B01L7/525B01L2400/0433B01L2400/06B25J21/02
Inventor 金拓郭柏松郑效东刘迪
Owner SHANGHAI TOFFLON SCI & TECH CO LTD
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