Application of Weichangan to preparation of alcoholic gastric ulcer resistant drugs

A technology for chronic gastric ulcer and gastric ulcer, which can be used in drug combinations, pharmaceutical formulations, plant raw materials, etc.

Inactive Publication Date: 2016-07-06
津药达仁堂集团股份有限公司乐仁堂制药厂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, Chinese and Western medicines account for a relatively large proportion of the treatment drugs for gastric ulcers. Drugs that inhibit gastric acid secretion and protect gastric mucosa are mostly used. Although they can quickly inhibit ulcers, their side effects are relatively large, and they are only palliative treatments. It is not a cure, so it is particularly important to choose more effective anti-ulcer drugs

Method used

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  • Application of Weichangan to preparation of alcoholic gastric ulcer resistant drugs
  • Application of Weichangan to preparation of alcoholic gastric ulcer resistant drugs
  • Application of Weichangan to preparation of alcoholic gastric ulcer resistant drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Prescription: Preparation of Weichangan Pill Extract:

[0039] Woody: 9.94 parts Agarwood: 9.94 parts Fructus Aurantii (fried with bran): 9.94 parts

[0040] Sandalwood: 5.96 parts Rhubarb: 5.96 parts Magnolia (Ginger): 9.94 parts

[0041] Musk: 0.30 parts croton cream: 3.97 parts jujube (with pits): 33.12 parts

[0042] Chuanxiong: 6.27 copies.

[0043] Weichangan pills are crushed, passed through a 40-60 mesh sieve, soaked in 6-10 times the mass volume of methanol for 2 to 4 hours, extracted with methanol reflux for 1 to 3 hours, extracted 2 to 4 times, the extract is filtered, and the filtrate is dried under reduced pressure. The crude extract is obtained.

Embodiment 2

[0045] The preventive effect of Weichang'an Pill on acute gastric ulcer caused by 90% ethanol:

[0046] Use 90% ethanol to create an acute gastric ulcer model for a short time, and observe the effect of the sample in preventing gastric ulcer. Weight 20-30g, randomly grouped according to body weight, at least 10 in each group, after 1 week of adaptive feeding, enter the experiment. Design three dose groups (prepared in embodiment 4), high dose group (0.8g / kg), middle dose group (0.4g / kg), low dose group (0.2g / kg), intragastric administration for 4-9 days (0.2mL / 20g), the blank group and the model group were given the same amount of distilled water and fasted for 24 hours before modeling. Thirty minutes after the last administration, each mouse was given 90% ethanol 0.12mL / 20g by gavage, and a mouse model of acute gastric mucosal injury was established after 1 hour.

Embodiment 3

[0048] The protective effect of Weichang'an Pill on chronic gastric ulcer caused by 50% ethanol:

[0049] Use 50% ethanol to cause chronic gastric ulcer model for a long time, and observe the protective effect of the sample on gastric ulcer. Weight 20-30g, randomly grouped according to body weight, at least 10 in each group, after 1 week of adaptive feeding, enter the experiment. Design three dose groups (prepared in embodiment 2), high dose group (0.8g / kg), medium dose group (0.4g / kg), low dose group (0.2g / kg). First, give high, medium and low dose samples by gavage, 0.2mL / 20g / d, 30min later, give 50% ethanol, 0.2mL / 20g / d, model group give the same amount of distilled water, 30min later, gavage The medicine was 50% ethanol, and the blank group was given the same amount of distilled water. The administration was continued for 3-8 weeks to observe the effect of the sample on chronic gastric mucosal damage caused by long-term ethanol.

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Abstract

The invention relates to an application of Weichangan to preparation of drugs for preventing and treating alcohol-induced acute and chronic gastric ulcers. Animal experiments show that a Weichangan extract has obvious inhibiting effects on gastric ulcer in mice caused by 90% of short-term alcohol and 50% of long-term alcohol, so that Weichangan can serve as a drug for preventing and protecting alcoholic gastric ulcer. Weichangan has the obvious advantages that Weichangan has small treatment side effects on diseases, is small in dosage, has good effects and has not only good prevention effects but also better treatment and protection effects on alcoholic gastric ulcer.

Description

Technical field [0001] The invention relates to the development of new indications for the prevention and protection of alcoholic gastric ulcers by the traditional Chinese medicine Weichangan, and belongs to the technical field of traditional Chinese medicine. Background technique [0002] In recent years, with the changes in lifestyle, dietary structure, and the increase in wine varieties and production, the proportion of drinking people has gradually increased, and the incidence of ethanol-related diseases has also increased year by year. Drinking a lot of high-alcohol products can cause gastric mucosal damage, leading to gastric mucosal congestion, edema, erosion, bleeding, and even ulcer formation. Patients may experience sudden hematemesis and melena, which can be life-threatening in severe cases. Studies have shown that the incidence of gastrointestinal diseases among drinking people is significantly higher than that of non-drinking people, and the incidence of acute alcoh...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/835A61P1/04A61K35/55
CPCA61K36/835A61K35/55A61K36/185A61K36/236A61K36/285A61K36/47A61K36/575A61K36/708A61K36/725A61K36/752A61K2300/00
Inventor 高文远张宇王玉晶尹云泽聂晓洁张静泽郑虹陈钰玲
Owner 津药达仁堂集团股份有限公司乐仁堂制药厂
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