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Autism serum polypeptide marker SERPINA5-A and application thereof

A technology for serum peptides and autism, applied in biological testing, material inspection products, measuring devices, etc., can solve problems such as the lack of quantifiable indicators

Inactive Publication Date: 2016-07-06
广东辰辉生物医学技术有限公司
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  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

The diagnosis of the disease originated from the observation of clinical symptoms of a group of patients. Since the diagnosis of autism, the diagnostic criteria have been revised many times due to the lack of quantifiable indicators.

Method used

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  • Autism serum polypeptide marker SERPINA5-A and application thereof
  • Autism serum polypeptide marker SERPINA5-A and application thereof
  • Autism serum polypeptide marker SERPINA5-A and application thereof

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Embodiment Construction

[0021] The autism serum polypeptide molecule provided by the invention is a newly screened autism serum diagnostic marker, its expression has specificity, and can be applied to autism diagnosis. The present invention will be further described in detail below in conjunction with specific embodiments, which are explanations of the present invention rather than limitations.

[0022] The specific screening of the serum diagnostic markers for autism is as follows:

[0023] First, the liquid protein chip technology was used to separate and extract the serum protein peptides of children with autism and normal controls, and MALDI-TOF-MS was used to capture the protein and peptide profiles of children with autism and normal controls, and the software ClinProTools2.1 was used to compare and analyze the protein peptides of children with autism. The differences in the serum protein and polypeptide spectra of children and normal people were used to find out the scores of protein polypeptid...

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Abstract

The invention discloses an autism serum polypeptide marker SERPINA5-A and the application thereof. The amino acid sequence of the marker is shown in SEQ.ID.NO.1. The molecule is called SERPINA5-A and is one fragment of SERPINA5, the exact molecular weight of the molecule is 3886 Daltons, SERPINA5-A is remarkably highly expressed in autism children sera diagnosis, and a method for detecting SERPINA5-A or ELISA by means of a matrix assisted laser desorption / ionization time-of-flight mass spectrometer (MALDI-TOF-MS) is used for detecting the expression level of SERPINA5 and can be used as an autism serum detection method.

Description

technical field [0001] The invention belongs to the technical field of autism detection, and relates to an autism serum polypeptide marker SERPINA5-A and an application thereof. Background technique [0002] Autism, also known as autism spectrum disorder (Autism Spectrum Disorders, ASD), is a generalized neurodevelopmental disorder characterized by loss of social function, abnormal verbal and nonverbal communication, and stereotyped limitations of behavior and interests. 1%. Generally, the onset occurs in early childhood before the age of 3 and lasts for life. The incidence rate of boys is 4 to 6 times that of girls. Research shows that early diagnosis and screening for ASD can help increase the chances that children with autism will benefit from early intervention. However, due to the lack of biomarkers, the current screening and diagnosis of ASD is mainly based on children's behavioral characteristics and developmental history, so there is controversy, and there is an ur...

Claims

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Application Information

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IPC IPC(8): G01N33/68
CPCG01N33/6818
Inventor 杨娟黄辰宋土生陈艳妮
Owner 广东辰辉生物医学技术有限公司
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