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New use of phenytoin sodium

A technology for sodium phenytoin and Parkinson's disease, applied in the field of sodium phenytoin, to achieve the effect of inhibiting, alleviating and improving dyskinesia

Inactive Publication Date: 2016-07-20
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, blocking voltage-gated sodium channels and inactivating them may be a new strategy for PD treatment

Method used

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Examples

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Embodiment Construction

[0017] Please refer to UngerstedtU:6-Hydroxy-dopamineinduceddegenerationofcentralmonoamineneurons.EurJPharmacol1968,5(1):107-110. For the conditions and operation methods of the climbing experiment, please refer to XinFang:Thesteppingtestanditslearningprocessindifferentdegreesofunilateral degrees hydroxydopamineinrats.NeurosciRes,55(2006)403-409. Please refer to M. Olsson:ForelimbAkinesiaintheRatParkinsonModel:DifferentialEffectsofDopamineAgonistsandNigralTransplantsasAssessedbyaNewSteppingTest:1995,May-315875)

[0018] Establish a PD rat model: Put Sprague Dawley (SD) rats into an electronic scale to measure their body weight, and then intraperitoneally inject them with 10% chloral hydrate (450 mg / kg) to anesthetize them until the rats are lifted upside down. After the rat did not move, and did not respond when pinching the limbs lightly, the rat was fixed in the prone position on the stereotaxic device (keep the micro-injector needle handle perpendicular to the operating plane)....

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Abstract

The invention relates to new use of phenytoin sodium. According to the new use, through injecting the phenytoin sodium into a rat body through intraperitoneal injection, improved conditions on dyskinesia of a 6-hydroxy-dopamine unilateral-lesion PD (Parkinson's Disease) rat model are observed from praxiology, so that application of phenytoin sodium in the preparation of drugs for relieving PD motor symptoms is sought. The novel drugs for treating PD, created by the invention, provide research carriers for researching the molecular mechanism of PD and dyskinesia and meanwhile provide a screening platform for the research and development of the novel drugs for treating PD.

Description

Technical field [0001] The invention relates to a new use of phenytoin sodium. Background technique [0002] Parkinson’s Disease (PD) is the second largest neurodegenerative disease in the world, second only to Alzheimer’s disease. Approximately 1% of the global population suffers from this disease, and the population is mostly concentrated in middle-aged and elderly people, which greatly reduces the quality of life and life expectancy of this population, and has caused serious social impact. The dopaminergic neurons in the substantia nigra compact area of ​​the midbrain are lost, and the substantia nigra-striatal dopamine pathway disorder caused by dopamine depletion is the main pathological feature of PD. The clinical symptoms of PD are mainly motor symptoms, usually manifested as slow motion, resting tremor, gait disturbance, and postural instability. As the disease progresses, the symptoms gradually intensify. These symptoms usually start on one side of the body and then sp...

Claims

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Application Information

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IPC IPC(8): A61K31/4166A61P25/16
CPCA61K31/4166
Inventor 朱红艳王子逸吴昊房方皓杨超
Owner SHANGHAI UNIV
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