30 results about "Phenytoin Sodium" patented technology

The invention relates to a synthetic method of phenytoin sodium, belonging to the technical field of biomedicine. The synthetic method of the phenytoin sodium comprises the following steps of oxidation reaction, condensation reaction and salt formation reaction, wherein a amidation reaction process is promoted through adding a phase transfer catalyst 4-dimethylamiopryidine in the condensation reaction; a two-phase system of n-butanol and water is adopted, so that the generation of diphenylacetylene diurea is greatly inhibited, and reaction time is obviously shortened; ethanol serves as a solvent in the salt formation reaction, after a sodium hydroxide ethanol solution reacts with phenytoin, cyclohexane with defective solvent ice is added to promote the phenytoin sodium to precipitate as white crystal, and compared with the salt formation reaction with water as a solvent, the phenytoin sodium is faster in precipitation rate and high in precipitation degree and purity.

The invention relates to the technical field related to medical instruments, and provides a biodegradable anastomosis nail. The biodegradable anastomosis nail comprises a degradable nail body, and an anti-inflammatory and antibacterial layer is arranged on the outer wall of the degradable nail body; the degradable nail body is made of degradable magnesium alloy containing Ag or degradable zinc alloy containing Ag; the anti-inflammatory antibacterial layer comprises an anti-inflammatory mixture, and the anti-inflammatory mixture comprises phenytoin sodium and a silver ammonia solution. The anastomosis nail is set to be made of Ag-containing degradable magnesium alloy or Ag-containing degradable zinc alloy, so that the anastomosis nail for intestinal anastomosis can be degraded in vivo through microorganisms, and the arranged anti-inflammation antibacterial layer can further play roles in inhibiting bacteria, sterilizing and inhibiting infection when a same anastomosis nail is degraded, so that the problems of chronic infection, chronic inflammation and the like caused by the anastomosis nail are reduced. The problems of the chronic infection, the chronic inflammation, pain, foreign body sensation and the like caused by remaining of the anastomosis nail in the body after an operation are solved.

The invention discloses a liquid chromatogram analysis method for detecting the drug content of phenytoin sodium in blood. The liquid chromatogram analysis method comprises the following steps: usinga liquid chromatogram analysis instrument and an ultraviolet detector to calibrate a standard solution, fitting to obtain a standard curve equation that y equals to the sum of a*x and b, taking a blood sample to be detected, after the blood to be detected is treated, using the liquid chromatogram analysis instrument and the ultraviolet detector to detect the sample to be detected as well to obtainy value of the blood to be detected, substituting the y of the blood to be detected into the standard curve equation, and carrying out calculation to obtain the relative concentration x of a target objective in the blood sample to be detected, wherein the concentration of the working solution of an internal standard substance is known, and the drug concentration of phenytoin sodium in the blood to be detected is calculated and obtained. According to the method, the accuracy of a quantitative result is improved, the analysis time is greatly shortened, the detection process is simple and quick,the blood concentration of phenytoin sodium inside the body of a patient during clinic treatment can be monitored better, and experimental foundation is provided for individual dosing of antiepileptic drug phenytoin sodium and the occurrence of reducing toxic and / or side effects.

The invention relates to a method for rapidly detecting phenytoin analogues in products. It specifically relates to a method for detecting whether phenytoin sodium or similar substances are contained in products suspected of being mixed with phenytoin sodium or similar substances. (2) Use an appropriate detector based on a specific electrochemical method to measure the specific electrochemical parameters of the mixed test solution; (3) According to the value of the parameter, it can be judged whether the product may be illegally added with phenytoin Sodium or similar antiepileptic substances. The method of the invention does not need to filter the sample solution, and the whole detection process only takes 2 to 3 minutes, and has the advantages of fastness, simplicity, safety, high sensitivity, environmental protection and the like.

The invention discloses a medicine composition for treating epilepsy by combined treatment of traditional Chinese medicine and western medicine, comprising active ingredients and pharmaceutic adjuvant. The active ingredients comprise traditional Chinese medicines and western medicines. The traditional Chinese medicines comprise rhizoma cyperi, gambir plant, white silkworm, radix gentiana, radix scutellariae, blackend swallowwort root, radish seed, rhizoma arisaematis, root of pilose asiabell, bighead atractylodes rhizome, fructus aurantii, haematitum, amber and rhizoma acori graminei. The western medicines are diazepam, carbamazepine and phenytoin. The medicine composition disclosed by the invention is convenient for taking and has outstanding curative effects, does not relapse after recovery and has cure rate of more than 98%.

A medicine "Suyusan" for treating intractable ulcer is prepared from phenytoin sodium, sodium benzoate, VC and 5 Chinese medicinal materials including pearl layer powder, borax, borneol, etc. throughuniformly mixing according to defined quantity. Its advantages include speeding up healing, no any toxic by-effect, high cure rate up to 98.7%, and no recurrence.

The invention discloses a compound syrup paste for treating epilepsy. Ginseng, vermilion, ruddle, amber, keel, Curcuma aromatica Salisb and Sichuan troops are ground into fine power, passed through a 100 mesh sieve and added with ground phenytoin sodium tablet with even stirring to obtain compound fine powder; licorice, grass-leaved sweetflag, rhizoma pinellinae praeparata, Baikal skullcap root, cassia twig, Indian bread with hostwood and dried ginger powder are ground and passed through a 10 mesh sieve, and soaked in a 80 to 90 DEG C warm water for 2 hours twice and filtered, and the filtrates are mixed; slag is added with water, boiled for 30 minutes and filtered; the three filtrates are mixed, condensed, added with brown granulated sugar, white granulated sugar, honey and so on with even stirring and stood to obtain condensed syrup; the syrup is added with the compound powder, edible preservative, boiled to be dissolved fully, stirred evenly and stood. Combining the Chinese medical herbs and Western medicines, the compound syrup paste has functions of supplementing vigour, treating epilepsy, arresting convulsion and reducing phlegm, and promoting urination and reducing turbid pathogenic factors, overcomes the drawbacks of using single Chinese medicine and single Western medicine, and radically cure epilepsy.

The invention discloses phenytoin sodium sustained-release gel which promotes periodontal regeneration, and the phenytoin sodium sustained-release gel is made of components of phenytoin sodium, PLGA sustained-release microspheres and poloxamer gel, wherein, the content of an active component, the phenytoin sodium is 2 to 5 mg / ml. The preparation method of the phenytoin sodium sustained-release gel which promotes the periodontal regeneration has the steps that firstly, the PLGA microspheres containing the phenytoin sodium is prepared in W / O / W type emulsified solvent volatilization method; secondly, the microspheres are mixed into 25 percent of the poloxamer gel, to produce microsphere gel containing 2 to 5 mg / ml phenytoin sodium. The invention provides a new safe, effective drug with acceptable price and easy promotion and application for local administration of periodontal disease therapy. The preparation method of the phenytoin sodium sustained-release gel provided by the invention is convenient, and has strong operability, the prepared sustained-release drug has stable performance, and the distribution of the microsphere graininess is more uniform.

The invention relates to a method for synthesizing phenytoin sodium, which belongs to the technical field of biomedicine. The synthetic method of phenytoin sodium of the present invention comprises oxidation reaction, condensation reaction, salt-forming reaction, in condensation reaction, has promoted amidation reaction process by adding phase-transfer catalyst 4-dimethylaminopyridine; Adopt n-butanol and water two-phase system , greatly inhibited the generation of by-product diphenylacetylene diurea, and the reaction time was significantly shortened; in the salt-forming reaction, ethanol was used as a solvent, and after the reaction of sodium hydroxide ethanol solution and phenytoin, cyclohexane, a poor solvent, was added to promote the reaction of phenytoin Sodium is precipitated as white crystals. Compared with the salt-forming reaction in which water is used as a solvent, phenytoin sodium precipitates at a faster rate, with a higher degree of precipitation and higher purity.