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Phenytoin sodium dropping pill and preparation method thereof

A technology of sodium phenytoin and sodium dripping pills, which is applied in the fields of pill delivery, pharmaceutical formulations, and medical preparations containing active ingredients, etc. It can solve problems such as inability to quickly exert drug effects, poor curative effect on arrhythmia, large volume and difficulty in swallowing, etc., to achieve The preparation process is simple and easy, the drug compliance is high, and the production cost is low

Inactive Publication Date: 2014-01-01
天津市聚星康华医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This product is also suitable for ventricular and supraventricular arrhythmias caused by digitalis poisoning, and has poor curative effect on arrhythmias caused by other causes
However, the products on the market are only ordinary tablets, which have the disadvantages of large volume, difficulty in swallowing, slow onset of effect after oral administration, and inability to quickly exert the drug effect. The majority of patients are in urgent need of new dosage forms.

Method used

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  • Phenytoin sodium dropping pill and preparation method thereof
  • Phenytoin sodium dropping pill and preparation method thereof
  • Phenytoin sodium dropping pill and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Each pill contains 100 mg of phenytoin sodium and is prescribed as:

[0017]

[0018] The preparation process is as follows:

[0019] After the polyethylene glycol-6000 was melted at 70°C, sodium phenytoin and glycerin were added, mixed, and stirred for 5 minutes. In ice water, take out and wash after about 10 minutes, place at room temperature, and dry to obtain phenytoin sodium dropping pills.

[0020] Evaluation: The prepared phenytoin sodium dropping pills have bright appearance, bad shape, and are easy to solidify during the dropping process.

Embodiment 2

[0022] Each pill contains 100 mg of phenytoin sodium and is prescribed as:

[0023]

[0024] The preparation process is as follows:

[0025] Same as Example 1.

[0026] Evaluation: The prepared phenytoin sodium dropping pills have bright appearance, bad shape and tailing.

Embodiment 3

[0028] Each pill contains 100 mg of phenytoin sodium and is prescribed as:

[0029]

[0030] The preparation process is as follows:

[0031] After melting polyethylene glycol-6000 at 80°C, add phenytoin sodium, mix and stir for 5 minutes. Under the condition of heat preservation, dropwise into liquid paraffin to form pellets, the drop distance is about 5cm, and then the liquid paraffin is placed in ice water. , about 10 minutes later, take out and wash, place at room temperature, and dry to obtain phenytoin sodium dropping pills.

[0032] Evaluation: The prepared phenytoin sodium dropping pills have bad appearance and tailing.

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Abstract

The invention belongs to the technical field of medicines, and relates to a phenytoin sodium dropping pill and a preparation method thereof. The phenytoin sodium dropping pill is applicable to treatment of generalized tonic-clonic seizures, complex partial seizures (psychomotor seizures and temporal lobe epilepsy) simple partial seizures (focal seizures) and status epilepticus, can also be used for treating trigeminal neuralgia, epidermolysis bullosa dystrophica recessive, paroxysmal choreoathetosis, paroxysmal control disorders (including behavioral disorders caused by hyperexcitability such as rage, anxiety, insomnia and the like), myotonia, cardiac conduction disorder during overdose of a tricyclic antidepressant and the like, and is also applicable to ventricular and supraventricular arrhythmias caused by digitalis toxication, with a poor therapeutic effect on cardiac arrhythmias caused by other various causes. Compared with currently marketed tablet products, the phenytoin sodium dropping pill has the characteristics of simple and feasible preparation process, rapid absorption and high bioavailability.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to a phenytoin sodium dropping pill and a preparation method thereof. Background technique [0002] Phenytoin Sodium (PHT-Na), also known as dalentine, is a sodium salt of diphenylhydantoin and is the drug of choice for anti-epileptic grand mal. Anti-mild hypertension. Because phenytoin has a wide range of biological activities and pharmacological therapeutic effects, it is often used in the treatment of other diseases in clinical practice. Many previous side effects are now being tried for the treatment of related diseases, and good results have been achieved, including promoting Wound healing, treatment of migraine, vertigo, hiccups, cardiovascular and cerebrovascular diseases, burns, auditory hallucinations in schizophrenia, anal itching, chlorpromazine-induced depression, scleroderma, etc. [0003] Animal experiments have shown that phenytoin has a selective antagonist...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/4166A61P25/08A61P25/06A61P25/24A61P25/18A61P1/08A61P17/02A61P17/04A61P17/00
Inventor 赵伟王红霞康静李化淋
Owner 天津市聚星康华医药科技有限公司
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