Biodegradable anastomosis nail and preparation method thereof

A staple and biological technology, applied in the field of medical devices, can solve problems such as pain, foreign body sensation, chronic infection, and staple residue, and achieve the effect of reducing the volume

Inactive Publication Date: 2021-10-08
THE SIXTH AFFILIATED HOSPITAL OF SUN YAT SEN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the embodiments of the present invention is to provide a biodegradable staple and its preparation method, aiming to solve the problems of chronic infection, chronic inflammation, pain and foreign body sensation due to the staple remaining in the body after the operation

Method used

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  • Biodegradable anastomosis nail and preparation method thereof
  • Biodegradable anastomosis nail and preparation method thereof
  • Biodegradable anastomosis nail and preparation method thereof

Examples

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preparation example Construction

[0040] The embodiment of the present invention also provides a method for preparing a degradable nail body. Taking magnesium alloy as an example, the preparation process of magnesium alloy includes the following steps:

[0041] 1) Take Zn4kg, Mn3kg, Sn1kg, Ag2kg, Mg72.8kg;

[0042] 2) drying each component weighed above at a temperature of 100° C. for 2 hours;

[0043] 3) Add the dried Zn, Mn, Sn, Ag and Mg to the graphite crucible and vacuumize it, then pass in a mixed gas of BF6 and CO2 as a protective gas, and dissolve each component completely under the condition of 700°C , kept for 30min to obtain a smelting solution;

[0044] 4) Pour the smelting solution into a pre-dried graphite mold to obtain a magnesium alloy ingot;

[0045] In one case of this embodiment, taking magnesium alloy as an example, the heat treatment process of magnesium alloy includes the following steps:

[0046] 1) solid-dissolving the magnesium alloy ingot obtained in the preparation process of mag...

Embodiment 1

[0063] The preparation of the degradable nail body of the anastomotic staple in this embodiment includes the following steps: take Zn4kg, Mn3kg, Sn1kg, Ag2kg, Mg72.8kg, and dry it in an oven at 100°C for 1-2 hours; dry the dried Zn, Mn, Sn , Ag and Mg were added to the graphite crucible to evacuate, and after evacuation, a mixed gas of BF6 and CO2 was introduced as a protective gas. After the components were completely dissolved at 700°C, they were kept for 30 minutes; a smelting solution was obtained; the smelting solution was Pour it into a pre-dried graphite mold to obtain a magnesium alloy ingot; put the magnesium alloy ingot into solid solution at 540°C for 11 hours; put the solid-solved magnesium alloy ingot or zinc alloy into the preheated mold, The preheating temperature is 250°C, and the extruded material is formed at a temperature of 400°C to obtain a degradable staple.

[0064] The preparation of the anti-inflammatory and antibacterial layer of staples in this embod...

Embodiment 2

[0068] The preparation of the degradable nail body of the staple in this embodiment includes the following steps: take Zn4kg, Mn3kg, Sn0.6kg, Ag18kg, Mg72.8, and dry it in an oven at 100°C for 1-2 hours; dry the dried Zn, Mn , Sn, Ag and Mg were added to the graphite crucible to evacuate, and after evacuation, a mixed gas of BF6 and CO2 was introduced as a protective gas. After the components were completely dissolved at 700 ° C, they were kept for 30 minutes; a smelting solution was obtained; Pour the smelting solution into a pre-dried graphite mold to obtain a magnesium alloy ingot; solidify the magnesium alloy ingot at 540°C for 11 hours; put the solid-dissolved magnesium alloy ingot or zinc alloy into the preheated mold In this method, the preheating temperature is 250°C, and extrusion molding is performed at a temperature of 400°C to obtain degradable staples.

[0069] The preparation of the anti-inflammatory and antibacterial layer of staples in this embodiment comprises...

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Abstract

The invention relates to the technical field related to medical instruments, and provides a biodegradable anastomosis nail. The biodegradable anastomosis nail comprises a degradable nail body, and an anti-inflammatory and antibacterial layer is arranged on the outer wall of the degradable nail body; the degradable nail body is made of degradable magnesium alloy containing Ag or degradable zinc alloy containing Ag; the anti-inflammatory antibacterial layer comprises an anti-inflammatory mixture, and the anti-inflammatory mixture comprises phenytoin sodium and a silver ammonia solution. The anastomosis nail is set to be made of Ag-containing degradable magnesium alloy or Ag-containing degradable zinc alloy, so that the anastomosis nail for intestinal anastomosis can be degraded in vivo through microorganisms, and the arranged anti-inflammation antibacterial layer can further play roles in inhibiting bacteria, sterilizing and inhibiting infection when a same anastomosis nail is degraded, so that the problems of chronic infection, chronic inflammation and the like caused by the anastomosis nail are reduced. The problems of the chronic infection, the chronic inflammation, pain, foreign body sensation and the like caused by remaining of the anastomosis nail in the body after an operation are solved.

Description

technical field [0001] The invention belongs to the related technical field of medical devices, in particular to a biodegradable staple and a preparation method thereof. Background technique [0002] Staples are medical devices used to suture the intestines in clinical operations. They use a stapler to perform intestinal anastomosis in a manner similar to that of a stapler. The anastomosis is fast and easy to operate, which can shorten the operation time and reduce wound exposure. time, thereby reducing the amount of blood loss during surgery. [0003] After the operation, staples may remain in the body, resulting in problems such as chronic infection, chronic inflammation, pain, and foreign body sensation. Contents of the invention [0004] The purpose of the embodiments of the present invention is to provide a biodegradable staple and its preparation method, aiming to solve the problems of chronic infection, chronic inflammation, pain and foreign body sensation due to t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/08A61L31/10A61L31/02A61L31/14A61L31/16A61B17/11A61B17/115C22C23/04C22C1/02C22F1/06C22C18/00C22F1/16
CPCA61L31/08A61L31/088A61L31/10A61L31/022A61L31/148A61L31/16A61B17/1114A61B17/115C22C23/04C22C1/02C22F1/06C22C18/00C22F1/165A61L2420/02A61L2420/04A61L2300/41A61L2300/404A61L2300/606A61L2300/104A61L2300/204A61L2300/30A61L2300/236C08L5/08C08L1/284
Inventor 林宏城马年方陈华显刘智敏曾建
Owner THE SIXTH AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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