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Application of Gynura procumbens to production of medicine, healthcare food or functional food for preventing and treating hyperuricemia

A technology for recumbent Chrysanthemum Panax notoginseng and hyperuricemia, which is applied in the functions of food ingredients, food ingredients containing natural extracts, application and other directions

Inactive Publication Date: 2016-08-10
JIANGXI HERBFINE HI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there have been no relevant reports on the lowering of uric acid and the treatment of hyperuricemia by supine chrysanthemum notoginseng at home and abroad

Method used

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  • Application of Gynura procumbens to production of medicine, healthcare food or functional food for preventing and treating hyperuricemia
  • Application of Gynura procumbens to production of medicine, healthcare food or functional food for preventing and treating hyperuricemia
  • Application of Gynura procumbens to production of medicine, healthcare food or functional food for preventing and treating hyperuricemia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1: The experimental method of supine chrysanthemum notoginseng aqueous extract on hyperuricemia (single model) mice induced by oxonate potassium

[0019] 50 mice were randomly divided into normal group, model group, high-dose and medium-dose (800, 400 mg / kg) and allopurinol (15 mg / kg) groups of supine chrysanthemum notoginseng water extract, 10 in each group. The medicines were all suspended with 0.5% CMC-Na, the normal group and the model group were given 0.5% CMC-Na by stomach, and the other groups were given the corresponding medicine solution, 0.2ml / 10g body weight, once a day, for 5 consecutive days, every day Before, the animals were fasted for 1 h.

[0020] One hour before the last administration, except the normal group, the animals in the other groups were intraperitoneally injected with oxonate potassium 450 mg / kg to establish a hyperuricemia model, and the normal group was injected with an equal volume of 0.5% CMC-Na, and administered 1 hour after ...

Embodiment 2

[0026] Example 2: The experimental method of the 50% ethanol extract of chrysanthemum notoginseng on the hyperuricemia rat model induced by hypoxanthine combined with potassium oxonate

[0027] Divide 50 rats randomly into: normal group, model group, high and medium doses (480, 240mg / kg) and allopurinol (10mg / kg) groups of chrysanthemum notoginseng 50% ethanol extract, a total of 5 groups , 10 in each group. All the drugs were prepared with 0.5% CMC-Na. The model group and the normal group were intragastrically administered the same volume of 0.5% CMC-Na, and the other drug groups were intragastrically administered the corresponding medicinal solution, 1ml / 100g body weight, for 5 consecutive days.

[0028] Hypoxanthine 500mg / kg was administered orally, and oxonic acid potassium salt 100mg / kg was subcutaneously injected to establish a hyperuricemia model. The last administration was performed 1 hour after the model was established, and the positive drug (allopurinol) was given ...

Embodiment 3

[0034] Example 3: The experimental method of the 95% ethanol extract of Pingbu notoginseng on the quail model of hyperuricemia induced by a high-purine diet

[0035] 60 quails were randomly divided into normal group, model group, high and medium doses (480, 240mg / kg) of 95% ethanol extract of Pingbu notoginseng and benzbromarone group (20mg / kg), a total of 5 groups, 12 in each group. Except for the normal group fed with common quail feed, all other groups were given high-purine feed (common feed mixed with yeast dry powder 15 g kg -1 d -1 , supplemented with common feed after eating), and had free access to drinking water. The normal group and the model group were administered with 0.5% CMC-Na, and the other groups were administered with corresponding drugs, 10ml / kg, and the experimental period was 14 days. After 14 days of administration, fasting and drinking water for 12 hours before blood collection, 2ml of blood was collected from the jugular vein of the animal, after s...

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Abstract

The invention discloses application of Gynura procumbens to the production of medicine, healthcare food or functional food for preventing and treating hyperuricemia. Evidence is provided to show that the Gynura procumbens has an evident effect of preventing and treating the hyperuricemia, can lower the serum uric acid value of a patient with the hyperuricemia, has an evident uric acid lowering effect and is capable of relieving the clinical symptoms of the patient with the hyperuricemia.

Description

technical field [0001] The present invention relates to a new application of chrysanthemum notoginseng, in particular to the application of chrysanthemum notoginseng in the preparation of medicines for preventing and treating hyperuricemia, health food or functional food, and belongs to the technical field of traditional Chinese medicine. Background technique [0002] Hyperuricemia (HUA) refers to that under normal purine diet, the blood uric acid level on an empty stomach twice in different days is higher than 420 μmol / L in men and higher than 360 μmol / L in women, which is called hyperuricemia. Uric acid is the end product of purine metabolism and is mainly excreted by the kidneys. Stable uric acid levels involve a balance between uric acid production, absorption, excretion, and breakdown. Once the above process is disturbed, it will lead to increased production of uric acid or decreased excretion, causing hyperuricemia. Recently, some scholars have pointed out that HUA i...

Claims

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Application Information

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IPC IPC(8): A61K36/28A61P19/06A23L33/00A23L33/105
CPCA61K36/28A23V2002/00A23V2200/30A23V2250/21
Inventor 冯育林李俊杨世林何明珍李志峰欧阳辉张武岗
Owner JIANGXI HERBFINE HI TECH
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