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Intensity modulated radiation therapy reverse optimization method based on biomedical equivalent uniform dose constraint

A biomedical and reverse optimization technology, applied in data processing applications, predictions, calculations, etc., can solve problems such as definitions that are difficult for clinicians to accept, and achieve easy acceptance and use, and simple solutions

Inactive Publication Date: 2016-11-30
NANYANG NORMAL UNIV
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Problems solved by technology

Therefore, this definition is difficult to be accepted by clinicians

Method used

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  • Intensity modulated radiation therapy reverse optimization method based on biomedical equivalent uniform dose constraint
  • Intensity modulated radiation therapy reverse optimization method based on biomedical equivalent uniform dose constraint
  • Intensity modulated radiation therapy reverse optimization method based on biomedical equivalent uniform dose constraint

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Embodiment 1

[0081] The implementation process of the inverse optimization method of intensity-modulated radiotherapy based on the equivalent uniform dose constraint of biomedical description includes three steps.

[0082] First, assign values ​​to the parameters in the definition of equivalent uniform dose based on biomedical description according to the characteristics of each organ, that is, to Assign values ​​to the two parameters b and k in , and verify the assignments through clinical experience.

[0083] Second, establish an intensity map optimization model based on the clinician's irradiation requirements for the target area and the equivalent uniform dose irradiation requirements for organs and tissues in non-target areas , and discretize the equivalent uniform dose constraints in the model according to the computing power of the computing equipment, so as to obtain the combinatorial optimization problem.

[0084] Third, according to the distance between the constrained hyperpl...

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Abstract

The invention discloses an intensity modulated radiation therapy reverse optimization method based on biomedical equivalent uniform dose constraint. By aiming at a defect of inevitable connection between a conventional equivalent uniform dose mathematical definition inability and actual clinical biomedical description, and by starting from a most frequently used dose volume curve in a biomedical model, a novel equivalent uniform dose mathematical model based on biomedical description is designed, and then an intensity modulated radiation therapy intensity graph constraint optimization mathematical model based on the above mentioned mathematical expression is acquired, a formed non-convex programming mathematical model is used for optimization solution by using a heuristic calculation method. An acquired optimization result is capable of satisfying dosage requirements of clinicians, and is used for personalized customization according to radiation tolerance conditions of cells in different organs of different patients. The optimization method can be directly used for intensity graph optimization modeling and calculating of a conventional static, dynamic, and volumetric modulated arc therapy.

Description

technical field [0001] The invention belongs to the technical field of mathematical optimization modeling and calculation of radiotherapy, and in particular relates to a reverse optimization method of intensity-modulated radiotherapy based on biomedical equivalent uniform dose constraints. Background technique [0002] At present, the dose constraint condition most widely used by clinicians is the dose volume constraint condition, which is derived from the concept of dose volume histogram. [0003] Dose-volume histogram for a given tissue (target or non-target) Can be expressed as follows: [0004] [0005] On the basis of the above mathematical expression of the dose volume histogram, the dose volume constraints of non-target and target tissue can be expressed. Non-target tissue: no more than % of organ tissue volume is subject to no more than Dose exposure in Gy, where Gy is the international unit of radiation dose intake. From dose volume histogram From the l...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06Q10/04
CPCG06Q10/04
Inventor 兰义华张新刚王保平李贞双张坤郭金良陈兴宋晓闵志方
Owner NANYANG NORMAL UNIV
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