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Application of prinsepia utilis royle in anti-benign prostatic hyperplasia drug

A technology for prostatic hyperplasia and green thorn tips, which can be used in drug combinations, medical preparations containing active ingredients, and pharmaceutical formulations, and can solve problems such as side effects, physical trauma, and low patient acceptance.

Inactive Publication Date: 2016-12-07
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Surgical treatment is effective, but it causes certain trauma to the body, and the patient acceptance is low
Although western medicine has a curative effect, it will produce certain side effects due to long-term use

Method used

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  • Application of prinsepia utilis royle in anti-benign prostatic hyperplasia drug
  • Application of prinsepia utilis royle in anti-benign prostatic hyperplasia drug
  • Application of prinsepia utilis royle in anti-benign prostatic hyperplasia drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Preparation of green thorn medicine

[0040] The preparation process of the green thorn sharp medicine is as follows: the green thorn sharp leaves are dried at 40°C to constant weight, soaked in water with 12 times the weight of the medicinal materials for the first time, soaked for 0.5 hours, refluxed for 1.5 hours, filtered, and the medicinal residues are added with 10 times the weight of the medicinal materials. Water, the medicinal solution is filtered out, first filtered with gauze and then with a 100-mesh sieve, and combined with water decoction.

Embodiment 2

[0042] Pharmacodynamic study on anti-testosterone propionate-induced benign prostatic hyperplasia in rats.

[0043] Experimental animals: 42 male SD rats, weighing 200g‐250g.

[0044] Test drug:

[0045] Test group 1: 1mg / kg finasteride group suspension (positive drug)

[0046] Test 2 groups: 7.2g crude drug / kg green thorn point extract suspension (high dose group)

[0047] Test 3 groups: 3.6g crude drug / kg green thorn point extract suspension (middle dose group)

[0048] Test 4 groups: 1.8g crude drug / kg green thorn point extract suspension (low dose group)

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Abstract

The invention discloses application of prinsepia utilis royle in an anti-benign prostatic hyperplasia drug. Leaves of prinsepia utilis royle are dried under the temperature of 40 DEG C to constant weight, the leaves of prinsepia utilis royle are soaked into water with the weight being 8-16 times that of the leaves of prinsepia utilis royle for 0.5-1 h, reflux extraction is performed for 1-2 h, after filtering is performed through three-layer gauze, filtering is performed through a 100-mesh screen cloth, water with the weight being 8-14 times that of medicinal materials is added into residues to be subjected to reflux extraction, medicine liquid is filtered out, and filtrates are combined. The prinsepia utilis royle extract can treat hyperplasia of prostate, improve the estrogen / androgen proportion mainly by lowering the androgen level and enhance the body oxidation resistance.

Description

technical field [0001] The present invention relates to a technique in the field of herbal medicine and medicine, in particular to the application of green thorns in anti-prostatic hyperplasia drugs. Background technique [0002] Green thorn point (Prinsepia utilis Royle) belongs to Rosaceae (Rosaceae) Prinsepia (Prinsepia) plant, and its medicinal use was first recorded in "Southern Yunnan Materia Medica". It has a wide range of medicinal uses and is commonly used by the Naxi, Bai, Yi, Mosuo and other ethnic groups in Yunnan. Modern pharmacological studies have proved that the flavonoids, terpenes, lignans, polysaccharides, fatty acids and other compounds contained in the green thorns have obvious antibacterial, blood lipid regulating, blood sugar lowering, improving immunity, anti-oxidation, Anti-inflammatory and other pharmacological effects, but there is no published literature reporting its research and application in the treatment of benign prostatic hyperplasia. [...

Claims

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Application Information

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IPC IPC(8): A61K36/73A61P13/08
CPCA61K36/73A61K2236/331A61K2236/39
Inventor 李晓波管晖彭崇胜彭颖
Owner SHANGHAI JIAO TONG UNIV
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