The invention discloses a chrysanthemum total flavone granule, which is made of the following raw materials in the weight ratio: sucrose powder: dextrin: dry extract powder of the total flavonoids of chrysanthemum = 0.5-1.5: 1.5-2.5: 0.5-1.5 . The present invention prepares chrysanthemum total flavonoids into granules. The granules have good formability, properties, particle size, water content, solubility, etc. all meet the requirements, and the quality is controllable and the stability is good. The color changes, the smell is lost, the content of active ingredients decreases, and the color of the item in the soaking process does not turn green. Chuju total flavonoids granules can significantly prolong the coagulation time of rats with cold coagulation and blood stasis syndrome, reduce the length of thrombus in vitro and dry and wet weight, reduce hematocrit, slow down erythrocyte sedimentation rate, and increase serum NO content. The product is easy to drink and carry, easy to store, has no toxic and side effects, and has the characteristics of preventing, treating and improving abnormal blood rheology in rats with blood stasis.