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Liver protection effect and application of sulforaphen in non-alcoholic fatty liver

A technology for sulforaphane and fatty liver disease, applied in the fields of application, additional food elements, digestive system, etc., can solve problems such as non-targeted drug treatment, achieve high-value transformation, slow down fatty degeneration, and promote intensive processing and utilization Effect

Inactive Publication Date: 2017-02-01
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no targeted drug therapy for the treatment of nonalcoholic fatty liver disease except changes in diet structure and living habits

Method used

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  • Liver protection effect and application of sulforaphen in non-alcoholic fatty liver

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1 Effect of sulforaphane on the body weight and major lipid metabolism organs of obese mice induced by high fat

[0044] figure 1 It is the graph of the change of mouse body weight after sulforaphane treatment, NS means that there is no statistical difference between the two, and it can be considered that the two are approximately equal. figure 1 A shows that feeding sulforaphane for 6 weeks has no significant change in the weekly mice body weight higher fat diet group, figure 1 B shows that after 6 weeks of feeding sulforaphane, the body weight of the mice was slightly reduced, but there was no statistically significant difference in the higher fat diet group. figure 2 showed no significant changes in liver weight and liver-to-body ratio; image 3showed no significant changes in epididymal fat pad weight and liposome ratio. It can be seen that treating obese mice induced by a high-fat diet with sulforaphane can not reduce the weight of obese mice, and the w...

Embodiment 2

[0045] Example 2 Effect of sulforaphane on food intake of obese mice induced by high fat

[0046] Figure 4 It is a graph showing the change of food intake of mice after being fed with sulforaphane. It can be seen that during the 6 weeks of feeding sulforaphane, the mice in the sulforaphane group consumed more food than the mice in the high-fat diet group. Statistically significant difference. It can be seen that sulforaphane can promote the appetite of mice, increase the food intake of mice, combined with figure 1 From the change chart of the body weight of the mice, it can be seen that the mice in the sulforaphane group eat more food, but the fat group with higher body weight tends to decrease.

Embodiment 3

[0047] Example 3 Effect of sulforaphane on liver morphology of obese mice induced by high fat

[0048] Figure 5 is the morphology of the tissue after sulforaphane-treated mice. It can be seen that the liver edge of the mice treated with sulforaphane is thinner, and there is no similar swelling phenomenon in the model group. The color of the liver is relatively normal, and there is no greasy feeling on the surface of the liver. Although the body weight of the mice treated with sulforaphane did not change significantly in the higher fat group, the state of the corresponding fatty liver was alleviated.

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Abstract

The invention discloses a liver protection effect and application of sulforaphen in non-alcoholic fatty liver, and belongs to the fields of biomedicine and food. According to the invention, the sulforaphen can be used for effectively treating liver diseases and decelerating lipid accumulation and steatosis of the liver, has the effect of obviously decelerating non-alcoholic fatty liver, and can reduce the glutamic-pyruvic transaminase and glutamic-oxaloacetic transaminase levels in blood, thereby opening a new way to treat fatty liver diseases and liver function impairment, having important meanings for development of edible and medicinal dual-purpose resources, realizing high-value transformation of active plant resources and promoting fine and deep processing and utilization of agricultural products. The sulforaphen having a liver protection effect can be widely used in the fields of food, medicine and the like, and has obvious social benefits and economic benefits.

Description

technical field [0001] The invention relates to the hepatoprotective effect of sulforaphane and its application in nonalcoholic fatty liver, belonging to the fields of biomedicine and food. Background technique [0002] Sulforaphane (1-isothiocyanate-4-methylsulfonylbutane), also known as "sulforaphane", is abundant in cruciferous plants such as broccoli, kale, and northern round carrots. Common antioxidants are plant active substances with good anti-cancer effects found in vegetables. In addition, sulforaphane also helps to clear bacteria in the lungs and prevent gout. These studies show that sulforaphane has a significant role in the prevention and treatment of chronic diseases. [0003] Fatty liver disease refers to excessive accumulation of fat in liver cells due to various reasons, resulting in increased fat content in liver cells. Possible reasons include alcoholism, diabetes, hyperlipidemia, and overweight. Non-alcoholic fatty liver disease (NAFLD) refers to a clin...

Claims

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Application Information

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IPC IPC(8): A61K31/26A61P1/16A23L33/10A23K20/00
CPCA61K31/26
Inventor 何钊吴逸宽朱升龙于月媛臧瑾吴海兰
Owner JIANGNAN UNIV
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