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A method for preparing alternate layered biodegradable polymer drug controlled release composite material

A polymer material and biodegradation technology, which is applied in the field of the preparation of alternate layered biodegradable polymer drug sustained-release materials, can solve the problem that the dosage and the dosing scheme are difficult to flexibly and effectively control, it is difficult to meet the industrialized large-scale production, and the compounding problems such as difficulty in drug administration, to achieve the effect of flexible and adjustable drug dosage, overcoming the difficulty of precise control, and improving the mechanical properties of materials

Active Publication Date: 2022-03-15
SICHUAN UNIV
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  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many deficiencies in these traditional homogeneous sustained-release preparations: the drug release of some preparation methods is nonlinear; the preparation form is relatively single, and it is difficult to flexibly and effectively control the dosage and administration plan, which increases the difficulty of compound administration; some preparations have poor stability, low efficacy
[0005] Although the above studies can overcome the problems of the traditional homogeneous drug-loading materials, such as the difficulty in flexible and effective control of the drug dosage and drug regimen, but due to the multi-use solution method for preparation, there are difficulties in solvent removal, and there are relatively large limitations in the choice of matrix and drugs. , The process is complex, it is difficult to meet the needs of industrial mass production

Method used

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  • A method for preparing alternate layered biodegradable polymer drug controlled release composite material
  • A method for preparing alternate layered biodegradable polymer drug controlled release composite material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] In the first step, the polymer-based drug immediate-release layer (hereinafter referred to as the immediate-release layer) uses polycaprolactone as the matrix of the immediate-release layer (molecular weight: 80,000), and polyethylene oxide as the dispersed phase of the immediate-release layer (molecular weight: 100,000), and The ingredients are 60%:40% by weight; metoprolol tartrate is the drug of the immediate release layer, and the ingredients are formulated according to 10% of the total weight of the polymer of the immediate release layer. The above-mentioned polymer and drug were mixed in a high-speed mixer for 5 minutes at a speed of 100 rpm to obtain a polymer-based drug immediate-release layer material.

[0050] The polymer-based drug slow-release layer (hereinafter referred to as the slow-release layer) selects polycaprolactone as the slow-release layer matrix (molecular weight is 80000), and metoprolol tartrate is the slow-release layer drug, and the percentage...

Embodiment 2

[0055] The polymer-based drug immediate-release layer (hereinafter referred to as the immediate-release layer) uses polybutylene succinate as the matrix of the immediate-release layer (molecular weight is 100,000); polyethylene oxide is the dispersed phase of the immediate-release layer (molecular weight is 200,000); and Percentage by weight 80%: 20% batching; Ibuprofen is an immediate-release layer medicine, and is batched according to 35% of the total weight of the immediate-release layer macromolecule. The above-mentioned polymer and drug were mixed in a high-speed mixer for 5 minutes at a speed of 100 rpm to obtain a polymer-based drug immediate-release layer material.

[0056] The polymer-based drug slow-release layer (hereinafter referred to as the slow-release layer) uses polycaprolactone as the matrix of the slow-release layer (molecular weight is 50000); polyethylene glycol is the dispersed phase of the slow-release layer (molecular weight is 6000); 95%: 5% batching; ...

Embodiment 3

[0061] In the first step, the polymer-based drug immediate-release layer (hereinafter referred to as the immediate-release layer) uses ethyl cellulose as the matrix of the immediate-release layer (molecular weight: 130,000), and polyethylene glycol as the dispersed phase of the immediate-release layer (molecular weight: 6,000). And with weight percentage 75%: 25% batching; Hydrochlorothiazide is the immediate-release layer medicine, carries out batching according to 30% of the macromolecule gross weight of the quick-release layer. The above-mentioned polymer and drug were mixed in a high-speed mixer for 5 minutes at a speed of 100 rpm to obtain a polymer-based drug immediate-release layer material.

[0062] The polymer-based drug sustained-release layer (hereinafter referred to as the sustained-release layer) selects ethyl cellulose as the matrix of the sustained-release layer (molecular weight is 130000), and metoprolol tartrate as the drug, 91% by weight: 9% in high blender ...

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Abstract

The invention is a method for preparing a biodegradable polymer drug sustained-release composite material, the main content of which is to make a polymer-based drug immediate-release layer and a polymer-based drug sustained-release layer with different release behaviors by means of melt co-extrusion Arranged alternately and orderly, using the shearing and stretching effects of the layer multiplier during multiple layered laminations to deform and orient the polymer during the extrusion process, improve drug diffusion and release channels, and make the obtained alternate layered Biodegradable polymer drug controlled release materials have a reasonable initial release concentration and required long-term release rate to achieve controllable, flexible and effective release of drugs to meet different drug release requirements. The alternate layered biodegradable polymer drug controlled-release material of the present invention has controllable form and adjustable formula; excellent mechanical properties; can be produced in batches continuously and is conducive to the improvement of production efficiency; has wide application range and broad industrialization and market prospects.

Description

technical field [0001] The invention relates to the preparation of an alternate layered biodegradable polymer drug slow-release material with configurable structure, designable performance, continuous production and flexible and controllable drug release behavior, which belongs to the field of functional composite material preparation. Background technique [0002] Compared with traditional drug delivery systems, drug sustained-release preparations do not require frequent drug administration, can maintain effective drug concentrations in the body for a long time, reduce the pain and inconvenience caused by frequent drug use, and can greatly improve drug efficacy and reduce toxic side effect. Polymer drug sustained-release materials are generally divided into two categories: non-biodegradable materials and biodegradable materials. Among them, biodegradable polymer materials do not require secondary surgery due to their good biocompatibility and non-toxicity, and metabolites h...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/34A61K47/38A61K47/10A61K47/36A61K47/32A61K9/00A61K9/20A61K31/192A61K31/138A61K31/4402A61K31/196A61K31/549
CPCA61K47/10A61K47/32A61K47/34A61K47/36A61K47/38A61K9/0002A61K9/2086A61K31/138A61K31/192A61K31/196A61K31/4402A61K31/549
Inventor 陈蓉郭少云张聪
Owner SICHUAN UNIV
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