Diagnosis kit for Parkinson's disease, and application of diagnosis kit

Abstract

The invention relates to a diagnosis kit for Parkinson's disease, and application of the diagnosis kit. According to the diagnosis kit, single-blind detection is carried out on the expression levels of miR-105-5p, miR-21-5p, miR-29a-5p and miR-30e-5p in plasma of 263 patients with the Parkinson's disease and a healthy control group of 242 hpersons having matched ages and sexes, and the four miRNAs are found to be significantly different in the plasma of patients with the Parkinson's disease and the plasma of healthy people, so that the four miRNAs are suggested to used as a molecular marker for preparing the kit for the Parkinson's disease, or to be used for preparing medicines for treating the Parkinson's disease. After the kit is used, the medication compliance has remarkable influence on the miR-21-5p, so that the kit can be used for screening the medicines for treating the Parkinson's disease.

Description

technical field [0001] The invention relates to the fields of biotechnology, disease diagnosis and biomedicine, in particular to a diagnostic kit for Parkinson's disease and its application. Background technique [0002] Parkinson's disease (PD), also known as parkinsonism, is the second most common neurodegenerative disease after Alzheimer's disease. In addition to motor symptoms such as resting tremor, muscle rigidity, and bradykinesia caused by nigrostriatal degeneration, non-motor symptoms such as anosmia, depression, autonomic dysfunction, and abnormal REM sleep behavior (rapideye movement sleep behavior disorder, RBD) and cognitive impairment are also important components of PD. With the aggravation of population aging, the prevalence of PD is increasing year by year, which has caused a serious burden to the patient's family and society. When PD patients have clinical symptoms, more than 60% of their substantia nigra dopamine neurons have died. At this time, drug tre...

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The above drugs can temporarily relieve and improve related symptoms,

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