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Application of a traditional Chinese medicine composition for promoting blood circulation and dispelling stagnation

A technology of promoting blood circulation and dissipating stagnation and composition, which is applied in the direction of drug combinations, medical preparations containing active ingredients, and pharmaceutical formulas, which can solve the problems of PVR recurrence, cell translocation and differentiation, etc., to inhibit abnormal cell proliferation and improve visual function , the effect of preventing and treating retinopathy

Active Publication Date: 2021-03-19
HUNAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Surgical treatment can only remove the formed hyperplastic membrane and restore the anatomical shape of the retina as much as possible. The success rate of anatomical reduction is only 60%-80% [7]. Surgery may stimulate cell translocation and differentiation again, leading to the recurrence of PVR
Therefore, many scholars have proposed the use of drugs to prevent the development of PVR, the main purpose is to anti-proliferation and inflammation, and these drugs are either in the experimental clinical stage, or because of drug toxicity, long-term complications and drug concentration, there is no drug for prevention and treatment. and clinical routine drugs for the treatment of PVR

Method used

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  • Application of a traditional Chinese medicine composition for promoting blood circulation and dispelling stagnation
  • Application of a traditional Chinese medicine composition for promoting blood circulation and dispelling stagnation
  • Application of a traditional Chinese medicine composition for promoting blood circulation and dispelling stagnation

Examples

Experimental program
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Effect test

Embodiment 1

[0030] This example provides a traditional Chinese medicine composition (oral liquid), which is prepared from the following raw materials by water decoction: 6g of Sanqi, 15g of Salvia miltiorrhiza, 18g of Dilong, 15g of seaweed, 15g of kelp and 15g of turtle shell.

[0031] The present embodiment provides the preparation method of above-mentioned oral liquid at the same time, specifically: mix raw material, add the water of 10 times of amount relative to the total amount of medicine wherein, decoct 30 minutes after soaking for 30 minutes, obtain mixed medicine liquid after filtering medicine dregs, put The mixed medicinal solution was concentrated to a crude drug concentration of 1.025 g / ml, and stored at 4°C.

Embodiment 2

[0033] This example provides a traditional Chinese medicine composition (oral liquid), which is prepared by decocting the following raw materials: 5 g of Panax notoginseng, 13 g of Salvia miltiorrhiza, 10 g of earthworm, 10 g of seaweed, 10 g of kelp and 10 g of turtle shell.

[0034] This embodiment also provides the preparation method of the above-mentioned oral liquid, specifically: this embodiment provides the preparation method of the above-mentioned oral liquid at the same time, specifically: mix the raw materials, add 10 times the amount of water relative to the total amount of the medicine, soak After 30 minutes, decoct for 30 minutes, filter the medicinal residues to obtain a mixed medicinal solution, concentrate the mixed medicinal solution to a crude drug concentration of 1.0 g / ml, and store in cold storage.

Embodiment 3

[0036] This example provides a traditional Chinese medicine composition (oral solution), which is prepared by decocting the following raw materials: 7 g of Panax notoginseng, 10 g of Salvia miltiorrhiza, 15 g of earthworm, 19 g of seaweed, 15 g of kelp and 15 g of turtle shell.

[0037] This embodiment also provides the preparation method of the above-mentioned oral liquid, specifically: this embodiment provides the preparation method of the above-mentioned oral liquid at the same time, specifically: mix the raw materials, add 10 times the amount of water relative to the total amount of the medicine, soak After 30 minutes, decoct for 30 minutes, filter the medicinal residues to obtain a mixed medicinal solution, concentrate the mixed medicinal solution to a crude drug concentration of 1.1 g / ml, and store in cold storage.

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Abstract

The invention provides a traditional Chinese medicine composition for activating blood to remove stasis and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from, by weight, 5-10 parts of Radix Notoginseng, 10-30 parts of Radix Salviae Miltiorrhizae, 15-30 parts of Pheretima, 10-30 parts of Sargassum, 10-30 parts of Thallus Laminariae seu Eckloniae, and 10-30 parts of Carapax Trionycis. By giving synergy of the specific Chinese medicines to play, the traditional Chinese medicine composition has the effects for activating blood to remove stasis and resolving hard lump, and can disperse tangible blood stasis and phlegm knot in eyes to significantly improve fundal condition of a PVR (proliferative vitreoretinopathy) patient and improve the visual function of the patient.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, more specifically, to a traditional Chinese medicine composition for promoting blood circulation and resolving stagnation, as well as its preparation method and application. Background technique [0002] Proliferative vitreoretinopathy (PVR) is a serious complication of retinal diseases such as rhegmatogenous retinal detachment, diabetic retinopathy, vitreous hemorrhage, and penetrating injury of the posterior segment of the eye. It is characterized by the formation of vitreous cavity, retinal surface and subretinal proliferative membrane, which is easy to cause traction retinal detachment (TRD). and the main cause of postoperative recurrence. It has been reported that 75% of retinal detachments fail due to PVR. Clinically, the incidence of PVR in rhegmatogenous retinal detachment is about 5%-10%. The occurrence of PVR is one of the causes of blindness. Mild PVR has sym...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/537A61P9/14A61P27/02A61K35/62A61K35/586
CPCA61K35/586A61K35/62A61K36/02A61K36/03A61K36/258A61K36/537A61K2236/331A61K2300/00
Inventor 彭清华彭俊吴权龙潘坤
Owner HUNAN UNIV OF CHINESE MEDICINE
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