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Ibuprofen suspension drops and preparation method thereof

A drop and suspension technology, applied in anti-inflammatory agents, pharmaceutical formulations, non-central analgesics, etc., can solve the problems affecting the safety and effectiveness of medication, affecting the accuracy of dosage, stratification, flocculation, and sedimentation and other problems to achieve the effect of improving high viscosity and caking problems, improving safety and effectiveness, and good taste

Inactive Publication Date: 2017-05-03
HAINAN HONZ PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, both suspensions and suspension drops are thermodynamically unstable systems, and commercially available ibuprofen oral suspensions are prone to delamination, flocculation, sedimentation and other unstable phenomena after long-term storage or high temperature conditions.
Affects the accuracy of dosage, especially for children, affecting the safety and efficacy of its medication

Method used

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  • Ibuprofen suspension drops and preparation method thereof
  • Ibuprofen suspension drops and preparation method thereof
  • Ibuprofen suspension drops and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The composition and dosage of 100mL ibuprofen oral suspension:

[0029]

[0030] Preparation:

[0031] 1) Weigh the microcrystalline cellulose-sodium carboxymethyl cellulose compound and add about 25% of the prescription calorimetry into purified water (60-80°C), homogenize (10000rpm) for 15min;

[0032] 2) Weigh xanthan gum and glycerin, mix well, then add about 15% of the prescription amount of purified water, and stir magnetically to swell;

[0033] 3) Weigh the pregelatinized starch, add 15% of the prescription amount to purified water, and stir for 5 minutes to make the dispersion uniform;

[0034] 4) Weigh fructose, sorbitol, citric acid, sodium benzoate, and essence respectively, add about 25% of the prescription amount to purified water, and homogenize (8500-10000rpm) to dissolve;

[0035] 5) Add the above three solutions into 1), mix and stir evenly, wash the bottle with an appropriate amount of purified water, add, stir homogeneously (8500-10000rpm);

[...

Embodiment 2

[0040] The composition and dosage of 100mL ibuprofen oral suspension:

[0041]

[0042] The preparation method is the same as in Example 1.

Embodiment 3

[0044] The composition and dosage of 100mL ibuprofen oral suspension:

[0045]

[0046] The preparation method is the same as in Example 1.

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Abstract

The invention relates to ibuprofen suspension drops, wherein a prescription of the suspension drops is composed of the components by weight: 4.0% of ibuprofen, 1.0-3.5% of pregelatinized starch, 1.0-5.0% of sorbitol, 4.0-5.0% of glycerol, 15.0-30.0% of fructose, 0.1-0.2% of citric acid, 0.1-0.2% of sodium benzoate, 0.05-0.1% of Tween 80, 0.05-0.5% of an essence, 0.6-1.5% of a suspending aid, and a proper amount of purified water. The dosage of the suspending aid used in the ibuprofen suspension drops is small, but an unexpected suspending effect is achieved, the suspending state stability can be kept in a wider temperature range, and the pungent taste of ibuprofen in mouthfeel is overcome. The invention also relates to a preparation method of the ibuprofen suspension drops.

Description

technical field [0001] The invention relates to a prescription composition of a pharmaceutical preparation and a preparation method thereof, in particular to an ibuprofen suspension drop and a preparation method thereof. Background technique [0002] Ibuprofen (Ibuprofen) was developed by the British Boots company in 1964. It is one of the most commonly used antipyretic and analgesic drugs in recent years. In addition to anti-inflammatory effects, it has significant analgesic and antipyretic effects and is very effective. It is safe, has lower toxicity, and is not easy to accumulate in the body. It is not only suitable for adults and the elderly, but especially for infants and young children. The U.S. has approved ibuprofen clinically since 1989 and can be used for antipyretic in infants and young children within 6 months. [0003] At present, the dosage forms of ibuprofen preparations that have been listed both at home and abroad are mainly oral. Children take oral tablets...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K31/192A61K47/38A61K47/36A61P29/00
Inventor 洪丽萍凌日金何清王稳奇
Owner HAINAN HONZ PHARMA
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