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A drug to treat hepatitis C

A hepatitis C and drug technology, applied in the field of drug preparation, can solve the problems of difficulty in purchasing and high cost, and achieve the effects of accelerating shedding, removing viruses, and reducing inflammation, necrosis, and fibrosis

Active Publication Date: 2020-06-12
KUNMING SINOWAY NATURAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In recent years, many companies at home and abroad have also made great progress in the research on the treatment of hepatitis C. However, there is still no imported or self-developed oral hepatitis C treatment in China. Therefore, for Chinese patients, there are high costs and difficulties in purchasing. Problems, due to these shortcomings, in order to meet the needs of patients with hepatitis C infection in my country, it is imperative to develop an innovative drug that is effective, inexpensive, and has low side effects for the treatment of hepatitis C.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A medicine for treating hepatitis C, achieved by the following methods:

[0033] A, the dry Periplaneta americana is crossed 10 mesh sieves and pulverized, and the gained Periplaneta americana coarse powder is soaked with the ethanol of 90% with concentration, makes the ethanol liquid level higher than the coarse powder liquid level 5cm, airtightly preserves one week, makes coarse powder mixture;

[0034] B, carry out ultrasonic extraction 4 times with step A gained coarse powder mixture:

[0035] The first ultrasonic extraction: the temperature is 30°C, the ultrasonic power is 20KHz, and the concentration of 90% ethanol is increased to 5 times the weight of coarse powder, and the extraction time is 30 minutes;

[0036] The second ultrasonic extraction: the temperature is 40°C, the ultrasonic power is 23KHz, and the concentration of 90% ethanol is 3 times the weight of the coarse powder, and the extraction time is 20 minutes;

[0037] The third ultrasonic extraction: ...

Embodiment 2

[0050] A medicine for treating hepatitis C, achieved by the following methods:

[0051] A, the dried Periplaneta americana is crushed through a 40-mesh sieve, and the obtained Periplaneta americana coarse powder is soaked in 70% ethanol, so that the ethanol liquid level is 10cm higher than the coarse powder liquid level, and it is stored in an airtight manner for 18 months. Coarse powder mixture;

[0052] B, carry out ultrasonic extraction 4 times with step A gained coarse powder mixture:

[0053] The first ultrasonic extraction: temperature 35°C, ultrasonic power 25KHz, add 8 times the weight of coarse powder with 70% ethanol, and the extraction time is 60 minutes;

[0054] The second ultrasonic extraction: the temperature is 40°C, the ultrasonic power is 28KHz, and the concentration of 75% ethanol is increased to 6 times the weight of coarse powder, and the extraction time is 50 minutes;

[0055] The third ultrasonic extraction: the temperature is 40°C, the ultrasonic powe...

Embodiment 3

[0068] A medicine for treating hepatitis C, achieved by the following methods:

[0069] A, the dried Periplaneta americana is crushed through a 20 mesh sieve, and the gained Periplaneta americana coarse powder is soaked in 75% ethanol, so that the ethanol liquid level is 6cm higher than the coarse powder liquid level, and it is stored in a sealed container for 12 months to obtain Coarse powder mixture;

[0070] B, carry out ultrasonic extraction 4 times with step A gained coarse powder mixture:

[0071] The first ultrasonic extraction: temperature 30°C, ultrasonic power 20KHz, add 5 times the weight of coarse powder with 75% ethanol, and the extraction time is 35-45 minutes;

[0072] The second ultrasonic extraction: the temperature is 40°C, the ultrasonic power is 23KHz, and the concentration of 80% ethanol is 3 times the weight of coarse powder, and the extraction time is 35 minutes;

[0073] The third ultrasonic extraction: the temperature is 45°C, the ultrasonic power is...

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Abstract

The invention relates to a medicine for treating hepatitis C. The medicine for treating the hepatitis C is prepared by a method comprising the following steps: soaking periplaneta americana in ethanol which is 60-95% in concentration; conducting ultrasonic extraction at 30-50 DEG C for 3-5 times; decompressing and concentrating obtained extracting solutions; adding water to obtained concentrated periplaneta americana ethanol liquid, stirring the concentrated liquid, preserving heat and standing by until the concentrated liquid is layered; decompressing and concentrating obtained lower water liquid, so that a periplaneta americana extractum for treating the hepatitis C is obtained; and drying and crushing the extractum so as to a a periplaneta americana extract for treating the hepatitis C, uniformly mixing the periplaneta americana extract and ribavirin at the ratio of 1-4: 5, and adding a pharmaceutically acceptable carrier, so that the medicine for treating the hepatitis C is prepared. The medicine can take an inhibitory effect on hepatitis C viruses, remove the viruses, relieve hepatic inflammation activity and fibrosis and prevent the further development of the hepatitis C into liver cirrhosis, and moreover, the medicine can promote the tissue regeneration of hepatic cells, accelerate exfoliation of necrotic hepatic cells and repair damaged hepatic cells at a high speed, so that purposes of repairing and protecting liver and curing the hepatitis C are achieved.

Description

technical field [0001] The invention relates to a medicine preparation method, in particular to a medicine for treating hepatitis C and a preparation method thereof. Background technique [0002] Hepatitis C is a viral hepatitis caused by hepatitis C virus (HCV) infection, which is mainly transmitted through blood transfusion, acupuncture, drug abuse, etc. According to the statistics of the World Health Organization, the global HCV infection rate is about 3%, estimated to be about 180 million People are infected with HCV, and about 35,000 new cases of hepatitis C occur each year. Hepatitis C is a global epidemic, which can lead to chronic inflammation, necrosis and fibrosis of the liver, and some patients can develop liver cirrhosis and even hepatocellular carcinoma (HCC). Cirrhosis is a common chronic liver disease. A variety of reasons cause liver damage, and the liver is progressive, diffuse, and fibrous. The specific manifestation is diffuse degeneration and necrosis ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/64A61P31/14A61P1/16
CPCA61K35/63
Inventor 郝振平徐溧
Owner KUNMING SINOWAY NATURAL PHARMA
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