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Biomarkers and combinations thereof for diagnosising tuberculosis

A biomarker, technology for tuberculosis, applied in biochemical equipment and methods, determination/examination of microorganisms, etc.

Active Publication Date: 2017-08-18
SEC OF STATE FOR HEALTH & SOCIAL CARE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Despite considerable investment in surveillance, control, and treatment programs, as well as in research and development of new diagnostics and treatments, TB control and eradication remains challenging

Method used

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  • Biomarkers and combinations thereof for diagnosising tuberculosis
  • Biomarkers and combinations thereof for diagnosising tuberculosis
  • Biomarkers and combinations thereof for diagnosising tuberculosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0318] Example 1 Identification of TB-specific biomarkers

[0319] Using aerosol challenge with Erdman strain K 01, live Mycobacterium tuberculosis pairs were obtained from two separate breeding colonies, naive South American macaques (foodstuffs) aged 2-4 years of Mauritius or Chinese provenance. crab monkeys) with two separate breeding colonies from established British or Chinese breeding facilities. These South American macaques were confirmed to have had prior exposure to segregation by using the interferon-gamma (IFN-γ)-based Primagam test kit, which was negative for tuberculin during their initial breeding colonies and prior to the start of this study. The aspect of mycobacterial antigens (M. tuberculosis infection or environmental mycobacteria) has never been tested. All procedures involving animals were approved by the Institutional Review Board of the Emergency Preparedness and Response Center in Salisbury, UK.

[0320] Particulate monodisperse bacteria were generat...

Embodiment 2

[0353] Example 2 Identification of TB Specific Biomarkers in UK Controls, TB Test Negative Controls, TB Test Positive Suspected Latent TB, Early Active and Confirmed Active TB Volunteers Cohorts

[0354] Whole blood samples were obtained from the following cohorts: (1) Caucasian controls—professional individuals recruited locally to the project group, constituting a low-risk group, from no / low TB endemic areas, such that these individuals had been exposed to Very low risk of TB (CC); (2) sub-ethnic controls recruited from Hindu monasteries in London with skin and / or IFNγ negative for TB and who were from areas with high TB ​​incidence (LC or NMRL CNTRL) (3) Individuals of subspecies recruited from Indian monasteries in London who were positive for TB in the Mantu skin and / or IFNγ test and diagnosed as latent TB (LTB or NMRL LTNT); (4) in St. Individuals with early active TB (EATB) recruited at the Isle of Thomas and the Royal Free Hospital in London; and (5) individuals diagno...

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Abstract

This invention relates to the detection and diagnosis of tuberculosis. More specifically, the invention relates to new biomarkers and combinations thereof that enable the accurate detection and diagnosis of tuberculosis.

Description

technical field [0001] The present invention relates to the detection and diagnosis of tuberculosis. More specifically, the present invention relates to novel biomarkers and combinations thereof that enable accurate detection and diagnosis of tuberculosis. Background technique [0002] Tuberculosis (TB) is a progressive, often fatal, infectious disease caused by the bacterial pathogen Mycobacterium tuberculosis (MTB). It is a significant cause of death worldwide, the eighth leading cause of death worldwide, and is primarily a disease of poverty, especially in developing countries. Latent TB infection is believed to affect as much as one-third of the world's population. [0003] Tuberculosis is a notifiable disease and is a major concern of many governments and other health groups including the World Health Organization (WHO), which has launched a number of control and treatment programs such as the "Stop TB Partnership". [0004] WHO estimates that nearly 9 million new ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68
CPCC12Q1/6883C12Q2600/158C12Q1/689
Inventor 卡伦·肯普塞尔奈吉尔·西尔曼莎丽·夏普安·威廉姆斯理查德·维庞德赛义德·贾韦德
Owner SEC OF STATE FOR HEALTH & SOCIAL CARE
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