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Complex probe of RGD-graphene/MnO2 magnetic nanospheres and application thereof

A technology of magnetic nanospheres and composite probes used in the field of tumor diagnosis and treatment

Active Publication Date: 2017-08-22
WUHAN INST OF PHYSICS & MATHEMATICS CHINESE ACADEMY OF SCI
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  • Abstract
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Problems solved by technology

Although the research on graphene-based MRI molecular probes has made some progress at home and abroad, it is still a huge challenge to apply graphene-based MRI molecular probes to the diagnosis and treatment of lung cancer. On the one hand, nano-probes are required to be highly The safety and dual-functionality of diagnosis and treatment, on the other hand, the probe molecules are required to have sufficient specificity and sensitivity

Method used

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  • Complex probe of RGD-graphene/MnO2 magnetic nanospheres and application thereof
  • Complex probe of RGD-graphene/MnO2 magnetic nanospheres and application thereof
  • Complex probe of RGD-graphene/MnO2 magnetic nanospheres and application thereof

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Embodiment 1

[0039] 1. MnO 2 Preparation of hollow magnetic nanoparticles:

[0040] 1.1, 3.96g MnCl 2 4H 2 O (20mmol), 18.25g sodium oleate (60mmol) were dissolved in a mixed solution of 40mL ethanol, 30mL water and 70mL n-hexane, heated at 70°C for 4h, cooled to room temperature (25°C) and separated into layers, and The upper organic phase was washed with 30 mL of water and a separatory funnel, and then the n-hexane was evaporated to obtain manganese oleate as a waxy solid product.

[0041] 1.2. At room temperature (25°C), stir and dissolve 6.2g manganese oleate (10mmol) and 1.43g (5mmol) into 50g 1-octadecene, then heat to 320°C at a heating rate of 3.3°C / min. When the reaction solution is heated to 320°C, a violent reaction will occur, the initial transparent solution will become turbid, and the color of the reaction solution will turn brown. Keep the reaction at 320°C for 30 minutes, cool the resulting mixed product to room temperature, and mix Add 500mL ethanol to the product, mix...

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Abstract

The invention discloses a complex probe of RGD-graphene / MnO2 hollow magnetic nanospheres and an application thereof. A preparation method is as follows: 1. preparation of MnO2 hollow magnetic nanoparticles; 1.1. preparation of oleic acid wrapped MnO2 solid magnetic nanoparticles OA@SMnO2; 1.2. preparation of BSA-OA@SMnO2; 1.3. preparation of HMnO2; 2. preparation of HMnO2 / Graphene; 3. preparation of the complex probe RGD-HMnO2 / Graphene of RGD-graphene / MnO2 hollow magnetic nanospheres. The complex probe is used for realizing lung cancer and tumour targeted MR development and targeted therapy, and providing a new thinking and opinion of early stage diagnosis and treatment of lung cancer.

Description

technical field [0001] The invention belongs to the technical field of diagnosis and treatment of tumors, and in particular relates to an RGD-graphene / MnO 2 Composite probes of magnetic nanospheres and their applications. Background technique [0002] Graphene, as a new type of two-dimensional nanomaterial, has the characteristics of good biocompatibility, cell transmembrane transport performance and easy surface modification, which provides a good substrate for the construction of molecular probes for the detection of cells, tissues and even living tumors. The reported molecular probes for graphene tumor detection can be roughly classified into the following five categories according to medical imaging techniques: fluorescence imaging, computed tomography (CT), and positron emission tomography (Positron Emission Tomography, PET), magnetic resonance imaging (Magnetic Resonance Imaging, MRI) graphene molecular probes. Among them, MRI is the preferred imaging modality for ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/14A61K49/08A61K49/18A61K47/02A61K47/18A61K31/704A61P35/00B82Y5/00B82Y15/00B82Y30/00
CPCA61K31/704A61K47/02A61K47/183A61K49/08A61K49/14A61K49/183B82Y5/00B82Y15/00B82Y30/00
Inventor 周欣毛小微陈世桢孙献平刘买利
Owner WUHAN INST OF PHYSICS & MATHEMATICS CHINESE ACADEMY OF SCI
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