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Method for determining dtpa-zn in human urine biological samples

A technology of biological samples and human urine, applied in the field of biomedicine, can solve the problem that lead is not enough to evaluate the behavior of DTPA in vivo

Active Publication Date: 2019-07-30
万舒(北京)医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In such a wide range of application environments, it is obviously not enough to evaluate the in vivo behavior of DTPA, a metal chelator, only by examining the distribution and content of lead in the body

Method used

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  • Method for determining dtpa-zn in human urine biological samples
  • Method for determining dtpa-zn in human urine biological samples
  • Method for determining dtpa-zn in human urine biological samples

Examples

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Embodiment Construction

[0069] The following examples of the present invention are provided for illustrative purposes only and are not intended to, nor should they be construed as, limiting the present invention in any way. Those skilled in the art will recognize that routine changes and modifications can be made to the following examples without departing from the spirit or scope of the invention.

[0070] An object of the present invention is to better understand the in vivo disposition rules of DTPA-Zn. The present invention has established and verified the liquid chromatography-tandem mass spectrometry (LC-MS / MS) method for quantitatively detecting the content of DTPA-Zn in biological samples. , while investigating the pharmacokinetic behavior of DTPA-Zn in the human body.

[0071] 1 Test overview

[0072] Zn-DTPA (diethyltriaminepentaacetic acid trisodium zinc salt, DTPA-Zn) is clinically used as a mitigation radiation chelation agent for the treatment of patients diagnosed or suspected to be...

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Abstract

The present invention relates to a method for determination of DTPA-Zn in a human urine biological sample. The method is used for determination of the DTPA-Zn in the human urine biological sample by liquid chromatography-tandem mass spectrometry, and comprises the following steps: (1) treatment of the biological sample, (2) determination by use of the liquid chromatography-tandem mass spectrometry and (3) data processing and analysis. The method exhibits excellent effects such as excellent chromatographic separation effect, as mentioned in the specification.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and relates to a reliable method for measuring the content of the above-mentioned metal chelating agent in biological samples such as blood, urine, etc. Therapeutic effects of these metal chelators or their behavior in vivo. [0002] In particular, the present invention relates to a method for the determination of DTPA-Zn in human urine biological samples. Background technique [0003] The harm of lead pollution and lead poisoning to human health has been widely concerned. Lead is a non-essential element for the human body. It enters the human body for absorption mainly through the respiratory tract and digestive tract. It can accumulate in the body and has toxic effects on various systems and organs throughout the body. It mainly affects the nervous, digestive, and blood systems. Lead pollution and lead poisoning need to be addressed. [HaoFT, Du XQ, Niu YM, et al. Progress in research of t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/06G01N30/88
CPCG01N30/06G01N30/88
Inventor 郭继芬孟繁华虞林李照丰
Owner 万舒(北京)医药科技有限公司
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