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Application of 1,6-hexanediol or its derivatives in the preparation of anti-blood tumor drugs

A tumor drug, hematological tumor technology, applied in the direction of anti-tumor drugs, drug combinations, active ingredients of hydroxyl compounds, etc., to achieve the effect of inhibiting the liquid phase separation process, good application prospects, and inhibiting the occurrence of

Active Publication Date: 2019-10-25
海安百优基质生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Whether the malignant transformation of tumor cells is achieved through excessive or abnormal liquid phase separation, and whether the development of new anti-tumor drugs can be based on inhibiting the liquid phase separation process as a starting point, but there is no report in this regard in the prior art

Method used

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  • Application of 1,6-hexanediol or its derivatives in the preparation of anti-blood tumor drugs
  • Application of 1,6-hexanediol or its derivatives in the preparation of anti-blood tumor drugs

Examples

Experimental program
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Effect test

Embodiment 1

[0021] 1. Experimental materials

[0022] 1,6-Hexanediol, supplied by Sigma;

[0023] RPMI medium, English name RPMI Medium Modified, supplier HyClone;

[0024] PBS (1×), supplied by HyClone;

[0025] Penicillin-Streptomycin Solution, English name Penicillin-Streptomycin Solution, supplier HyClone;

[0026] Fetal bovine serum, supplier Hangzhou Sijiqing Bioengineering Materials Co., Ltd.;

[0027] CCK-8, English name Cell Counting Kit-8, supplier Dojindo Laboratories;

[0028] PI, English name Propidium Iodide, supplier Sigma.

[0029] 2. Experimental method

[0030] 1. Configuration of 1,6-hexanediol solution and PI staining solution

[0031] 1,6-Hexanediol powder is dissolved in sterile water, the storage concentration is 1g / mL, and stored in the dark at 4°C;

[0032] PI was dissolved in PBS, the storage concentration was 10mg / mL, and stored in the dark at 4°C.

[0033] 2. Cell culture

[0034] Diffuse large B-cell lymphoma cells HBL-1, SUDHL-2, myeloma cells U266, ...

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Abstract

The invention discloses application of 1,6-hexanediol or derivatives thereof in preparation of hematologic tumor resistant drugs. The 1,6-hexanediol or derivatives thereof are capable of damaging weak interaction of proteins, inhibiting the liquid phase separation process and effectively inhibiting occurrence and development of tumors. The 1,6-hexanediol is capable of relatively specifically inhibiting cell proliferation of diffused large B cell lymphoma, myeloma and other hematologic tumors, and has excellent application prospects in preparation of anti-tumor drugs for preventing and treating leukemia, lymphoma, multiple myeloma and the like.

Description

technical field [0001] The invention relates to the technical field of anti-tumor drugs, in particular to the application of 1,6-hexanediol or its derivatives in the preparation of anti-blood tumor drugs. Background technique [0002] 1,6-Hexanediol, the English name is 1,6-hexanediol, the structural formula is: As an important fine chemical material, 1,6-hexanediol is widely used in polyurethane, polyester, coil coating, light curing agent and other fields. In addition, due to its certain permeability, 1,6-hexanediol can also be used in cosmetic active ingredients and topical pharmaceutical compositions for skin diseases, but its application in antitumor drugs has not been reported. [0003] Leukemia, lymphoma, and multiple myeloma are the major forms of blood cancer. Acute leukemia ranks eighth among common malignant tumors, and lymphoma is also among the top ten, and its incidence is increasing year by year. The overall incidence of multiple myeloma accounts for 10% of...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/047A61P35/00A61P35/02
CPCA61K31/047
Inventor 范义辉毛仁芳吴圆圆杨日云汪晓莺陈霞王守艳
Owner 海安百优基质生物工程有限公司
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