Chlorin artesunate conjugate with photo- and sound-sensitizing activity and its preparation method and application

A chlorin artemisia annua and conjugate technology, applied in the field of chemical medicine, can solve the problems of slow clearance rate, low production of reactive oxygen species, low tumor cell selectivity, etc.
CN107417706BActive Publication Date: 2019-07-16DALIAN UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
DALIAN UNIV OF TECH
Publication Date
2019-07-16

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Abstract

The invention relates to a chlorin and artesunate compound with photosensitive and sound-sensitive activity as well as a preparation method and an application of the compound and belongs to the technical field of chemical medicines. The chlorin and artesunate compound with photosensitive and sound-sensitive activity has different degrees of inhibition effects on human hepatoma cells Hep G2 in in-vitro anti-tumor activity evaluation. The photoactivity and ultrasonic activity are both higher than that of chlorin e6 and artesunate which are used as positive controls. The compound can be used for preparing a photosensitizer and a sound-sensitive agent in photodynamic therapy and sonodynamic therapy methods for tumor therapy.
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Description

technical field

[0001] The invention relates to a class of chlorin artesunate conjugates with light and sound-sensitivity activities, a preparation method and application thereof, and belongs to the technical field of chemical medicine. Background technique

[0002] Photodynamic therapy (PDT) and sonodynamic therapy (SDT) use photosensitizer or photosensitizer (Sonosensitizer) to kill tumor cells by chemical reaction under light or ultrasound excitation, respectively. A medical technique for therapeutic purposes. Among them, photodynamic therapy (Photodynamic therapy, PDT) is the use of photosensitizers and visible light in an environment with oxygen to generate reactive oxygen species through photoreaction to cause tumor cell death or apoptosis. Compared with traditional treatment methods such as surgery, chemotherapy, and radiotherapy, PDT has the advantages of high selectivity to target tissues, less side effects, and no damage to internal organs; Sonodynamic therapy (SD...

Claims

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