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Kit-of-parts to identify mother's milk missing fucosyltransferase-2 dependent glycans and feeding doses with said glycans

A technology of fucose base and kit, applied in food ingredients, functions and applications of food ingredients, etc.

Inactive Publication Date: 2018-01-09
SOC DES PROD NESTLE SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this is not an inexpensive simple analysis that can be performed regularly and at home

Method used

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  • Kit-of-parts to identify mother's milk missing fucosyltransferase-2 dependent glycans and feeding doses with said glycans

Examples

Experimental program
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Embodiment

[0055] figure 1 The diagnostic kit according to the present invention is shown, which includes a rectangular matrix (1) with a series of lectins from wattle and a series of whey protein-specific antibodies (both of which are bound to a dye). The substrate can put the noodles on which the series are in the milk. Then, at the height of the milk application window (6), the surface of the matrix with the series should be put into the transparent device (3) at the position (4). Using the readout window (5), the position of the series and the presence of 2'fucosylglycans should be determined, provided that the position of the control series representing whey protein appears in the expected position.

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Abstract

Described is a matrix to identify mother's milk missing fucosyltransferase-2 (FUT2) dependent glycans which comprise a line of a glycan binding protein such as a lectin or antibody suitable to bind 2'fucosyl-glycans and a line of a positive control to bind a mother's milk protein. For instance, this matrix is porous and allows for transport by capillary force of compounds of mother's milk such asglycoproteins. Especially, the glycan binding protein is the plant lectin from Ulex europaeus. A diagnostic kit comprising one or more of such matrices and a device suitable to receive such a matrix provided with a milk application window and a read-out window has been described as well. Finally a kit-of-parts comprising such a diagnostic kit and one or more feeding doses of 2'fucosyl-glycans hasbeen disclosed.

Description

Technical field [0001] The present invention relates to a matrix and a diagnostic kit including the matrix for identifying the lack of 2'fucosyl glycans (fucosyltransferase-2 (FUT2) related glycans) in breast milk. In addition, the present invention relates to a kit including such a diagnostic kit and 2'fucosylglycan. Background technique [0002] Human milk contains a variety of different oligosaccharides, most of which are fucosylated, see, for example, Newburg, J Anim Sci, 2009; 87 (Suppl 1); 26-34 (Newburg, "Animal Science Journal, 2009, Vol. 87 (Supplement 1), pp. 26-34). However, different women synthesize different subtypes of oligosaccharides, and the total amount and relative abundance of human milk oligosaccharides also vary during lactation. [0003] It has been found that the most obvious difference between humans is related to the fucosylation of human milk oligosaccharides and this difference is based on the genetically determined female secretion type and Lewis blo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/53A23C9/20A23L33/00
CPCA23C9/206G01N2333/42G01N2400/02G01N2400/12A23L33/40A23V2002/00G01N33/5308A23V2200/32A23V2200/324A23V2250/284
Inventor D·布拉萨特N·斯普伦格
Owner SOC DES PROD NESTLE SA
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