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A kind of compound plant lectin and its preparation method and application

A plant lectin and drug technology, applied in the direction of plant raw materials, plant/algae/fungus/moss components, drug combinations, etc., can solve the problems of reducing patient tolerance and compliance, aggravating the disease, slow onset of action, etc., to achieve Improve the effect of adjuvant therapy, facilitate absorption and utilization, and have high permeability

Active Publication Date: 2020-12-11
西安和众人生生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned drug therapy still has some shortcomings. For example, Western medicine is mostly symptomatic treatment, which treats the symptoms but not the root cause, and the disease is prone to relapse, many adverse reactions, drug resistance, and long-term use will also produce dependence and withdrawal reactions. ; Although oral Chinese medicine can fundamentally regulate the disease comprehensively, the onset of effect is often slow and the curative effect is not exact. In addition, taking Chinese medicine needs to be treated based on syndrome differentiation, and taking it casually is likely to be ineffective or even aggravate the condition. Deficiencies largely reduce patient tolerance and compliance

Method used

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  • A kind of compound plant lectin and its preparation method and application
  • A kind of compound plant lectin and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A compound plant lectin, made from the following raw materials in parts by weight:

[0030] 1 part of notoginseng, 1 part of Eucommia, 1 part of kudzu root, 1 part of rehmannia glutinosa, 1 part of salvia miltiorrhiza, 1 part of kelp, and 1.5 parts of fern leaves.

[0031] The preparation method is as follows:

[0032] (1) Weigh the dried medical materials of Panax notoginseng, eucommia, kudzu root, rehmannia glutinosa, salvia miltiorrhiza, kelp, and fern leaves, mix and grind them into 50-mesh drug powder;

[0033] (2) Add 5 times the volume of Tris buffer solution (50mmol / L Tris-HCl, 1mmol / LMgCl2, 1mmol / L CaCl2, pH8.0) to the above drug powder, homogenate, soak for 12 hours at 4°C, then 4 Centrifuge at 3000rpm for 15min at ℃, and take the supernatant;

[0034] (3) The obtained supernatant is filtered by a hyperosmotic agglutination method, and macromolecular substances such as protein, starch, pectin, tannin and microorganisms are filtered out to obtain a filtrate c...

Embodiment 2

[0037] A compound plant lectin, made from the following raw materials in parts by weight:

[0038] 1 part of notoginseng, 1 part of Eucommia, 1 part of kudzu root, 1 part of rehmannia glutinosa, 1 part of salvia miltiorrhiza, 1 part of kelp, and 1.5 parts of fern leaves.

[0039] The preparation method is as follows:

[0040] (1) Weigh the dried medical materials of Radix Notoginseng, Eucommia, Radix Puerariae, Radix Rehmanniae Radix, Salvia Miltiorrhiza, Kelp, and Fernia leaves, mix and grind them into 100-mesh drug powder;

[0041] (2) Add 5 times the volume of Tris buffer solution (50mmol / L Tris-HCl, 1mmol / LMgCl2, 1mmol / L CaCl2, pH8.0) to the above drug powder, homogenate, soak for 12 hours at 4°C, then 4 Centrifuge at 3000rpm for 15min at ℃, and take the supernatant;

[0042] (3) The obtained supernatant is filtered by a hyperosmotic agglutination method, and macromolecular substances such as protein, starch, pectin, tannin and microorganisms are filtered out to obtain a...

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Abstract

The invention relates to the field of natural medicine, in particular to compound phytolectin and a preparation method and application thereof. The compound phytolectin is prepared from pseudo-ginseng, eucommia ulmoides, root of kudzu vine, rehmannia, root of red-rooted salvia, kelp and silverweed cinquefoil root leaves, wherein the compound phytolectin contains the components of salvianic acid, salvia miltiorrhiza flavones, notoginsenoside, rehmannia saponin, rehmannin, laminaran, pueraria flavones and eucommia ulmoides terpene. Pharmacological experiments prove that the compound phytolectinhas an ideal therapeutical effect for hypertension, when the compound phytolectin is cooperatively used with hypotensive drugs, the antihypertensive efficacy is further strengthened and is obviously superior to exclusive use of hypotensive drugs, and the toxic and side effects such as edema of hypotensive drugs after cooperative use are greatly reduced. Moreover, the compound phytolectin is a natural preparation, is safe and reliable to use, is applicable for various types of hypertension patients, and is extremely suitable for current clinical requirements.

Description

technical field [0001] The invention relates to the field of natural medicines, in particular to a compound plant lectin and its preparation method and application. Background technique [0002] Hypertension (hypertension) refers to an increase in systemic arterial blood pressure (systolic and / or diastolic) as the main feature (systolic blood pressure ≥ 140 mm Hg, diastolic blood pressure ≥ 90 mm Hg), which may be accompanied by heart, brain, kidney, etc. Clinical syndrome of functional or organic damage to organs. Hypertension is the most common chronic disease and the main risk factor for cardiovascular and cerebrovascular diseases. [0003] Drugs for the treatment of hypertension mainly include Western medicines such as renin-angiotensin converting enzyme inhibitors, calcium ion antagonists, diuretics, vasodilators, and sympathetic nerve inhibitors, as well as many traditional Chinese medicine prescriptions. However, the above-mentioned drug therapy still has some short...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/804A61K38/16A61P9/12
CPCA61K36/03A61K36/258A61K36/46A61K36/488A61K36/537A61K36/73A61K36/804A61K38/168A61K2236/331A61K2236/51A61K2236/53A61K2300/00
Inventor 刘洋王学英安然
Owner 西安和众人生生物科技有限公司
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