35results about How to "Suitable for clinical needs" patented technology

The invention relates to a medical nano fiber enhanced composite material. The composite material comprises a base material and nano short fiber, wherein the nano short fiber keeps a crystal form andis uniformly distributed in the base material, and the nano short fiber accounts for 1-50 mass percent of the composite material. The composite material has the advantage that a single-component polymer material has high break elongation and high flexibility, has little damage to blood vessels and other tissues, has high tensile strength and high break elongation in human tissues, and greatly improves the tensile strength of the material. The medical nano fiber enhanced composite material has high biocompatibility and biodegradability, and can meet clinical demands of medical materials.

The invention provides a primer combination for detecting an allele CYP2C19*3. The primer combination includes an upstream primer p1, a downstream primer p2, a gene extension primer p3 and a gene extension primer p4 respectively having the sequences shown in Seq ID No.1-4. The invention also provides a primer combination-containing kit for detecting the allele CYP2C19*3. Based on design thoughts of specific primer extension and a high-resolution melting curve, genotyping can be directly carried out in a premise of not carrying out special amplification post-processing. The method perform genotyping by using a fluorescent dye identification extension product, requires no use of special labeled probes, and is simple in method, low in cost, and easy to popularize in clinic.

The invention discloses a spine nail rod hook device which comprises a connection rod. A spine fixing nail, a spine universal nail and multiple connection hooks are fixed to the connection rod, the spine fixing nail, the spine universal nail, the connection hooks and the connection rod are fixed through fixing screws, and the sides of the connection hooks are provided with thread holes matched with vertebra pedical nails. The spine nail rod hook device is simple in structure, high in safety, and capable of meeting clinic requirements and reducing soft tissue interference to the maximum. When the spine nail rod hook device is in use, the spine fixing nail and the spine universal nail can be rapidly screwed in, the purpose of connecting spongiosa with cortical bone more firmly can be achieved, meanwhile, the lamina hooks can be effectively positioned due to the fact that the sides of the lamina hooks are provided with the thread holes, and use is convenient.

The invention discloses a medical nanofiber reinforced hydrophilic composite material as well as a preparation method and application thereof. The composite material is prepared from a hydrophilic basis material and nano staple fibers, wherein the nano staple fibers are maintained in crystal morphology and are uniformly dispersed in the hydrophilic basis material; the mass percent of the nano staple fibers in the composite material is 1 to 30 percent; the nano staple fibers have the diameters of 200nm to 800nm and the lengths of 10mu m to 100mu m; according to the preparation method of the medical nanofiber reinforced composite material, which is provided by the invention, the technological design is peculiar; the nano staple fibers are uniformly dispersed in the basis material by utilizing the solubility difference of the basis material and the nano staple fibers; the multicellular spongy composite material is obtained by adopting a freeze drying method; the composite material keeps the respective advantages of two materials; defects are complementary; the composite material which is excellent in mechanical performance, good in biocompatibility and good in biodegradability is obtained, and the medical nanofiber reinforced hydrophilic composite material is moderate in degradation cycle, cannot cause a postoperative inflammation and the postoperative risk of adhesion, is more suitable for clinical demand.

The invention discloses an intramedullary interlocking internal nail which comprises a cylindrical main body. The main body is provided with a far end and a rear end opposite to the far end. A locking hole is formed in the far end close to the body. An included angle smaller than 90 degrees is formed between the locking hole and the axial direction of the main body. The main body is provided with a hollow cavity in the axial direction of the main body. A self-locking structure is arranged at the position of the near end of the main body. The self-locking structure is communicated with the hollow cavity. A core rod is inserted into the hollow cavity. The core rod axially moves so as to move the self-locking structure to expand outwards. The intramedullary interlocking internal nail is simple in structure, high in safety, suitable for clinic requirement and high in intramedullary nail tensile strength, and when the intramedullary interlocking nail is in use, the near end can be locked, and the purposes that a surgical incision is small and operation is rapid and convenient can be achieved.

The invention relates to a patella locking plate which comprises a bone plate set main body and shaping devices. The front side of the bone plate set main body is of a circular ring shape; the lateral surface of the bone plate set main body is of an arc shape; two mutually crossed fixed strips are connected to the inside of the bone plate set main body; 8 or more threaded holes are formed on the circular ring-shaped face of the bone plate set main body; both ends of each fixed strip are respectively connected to the inside of one threaded hole; the shaping devices 2 are connected to the insides of the threaded holes; a pressurizing hole is formed at the crossed position of the two fixed strips. According to the invention, by design of the shaping devices, people can more rapidly and accurately screw in locking screws so as to fulfill the aim of more firmly connecting the bone.

The invention relates to a proximal femur locking bone fracture plate. The proximal femur locking bone fracture plate comprises a top side surface, a bottom side surface used for being contact with a femur, and a group of through holes, wherein the top side surface is of an arc-shaped structure, at least one through hole is formed by the superposition parts of a pressing hole and a threaded hole, the pressing hole is a circular and thread-free, and an antibiotics layer is arranged on the inner side of the threaded hole. The proximal femur locking bone fracture plate provided by the invention has the advantages that the structure is simple, the safety is high, clinical demands are met, the bending strength of the bone fracture plate is high, when in use, locking screws can be screwed into quickly, the purpose of connecting bones more firmly is realized, in addition, the antibiotics layer covers on the inner wall of the threaded hole, a stronger antibacterial effect is realized, and the healing of fracture bones is accelerated.

The invention relates to a fibula locking bone plate which comprises a stem body mainboard and a side wing mainboard. The stem body mainboard is a recessed arc-shaped strip-shaped fixing plate, the side wing mainboard is a recessed arc-shaped fixing plate, the recessed radian of the stem body mainboard is the same as the recessed radian of the side wing mainboard, the stem body mainboard is provided with three or more first locking screw holes, the side wing mainboard is provided with four second locking screw holes and further provided with three Kirschner wire holes, and one end of the stem body mainboard disconnected with the side wing mainboard is also provided with a Kirschner wire hole. Through the design of the matching of the stem body mainboard and the side wing mainboard and the fibula of the human body, the locking bone plate adheres to the fibula better after being installed, the damage to a patient is reduced, and the healing speed is improved.

The present application discloses an inverted humerus intramedullary nail, which includes a first rod body located at the distal end and a second rod body located at the proximal end, the first rod body and the second rod body are coaxially connected into one body, and the second rod body The outer diameter of the first rod body is larger than that of the first rod body, and four first round holes and one second round hole are opened on the second rod body, and the four first round holes are respectively perpendicular to the axis of the second rod body direction, and the four first round holes form a certain angle with each other, and the angle between the second round hole and the axial direction of the second rod body is 45°, and the first rod body is provided with two The third circular hole, the two third circular holes are perpendicular to the axial direction of the first rod body, and a certain angle is formed between the two third circular holes. The inverted humeral intramedullary nail provided by the new model has simple structure and high safety, and is suitable for clinical needs. The intramedullary nail has high tensile strength, can be used for femoral shaft fractures, and can achieve the purpose of small surgical incision and fast and convenient surgery.

The invention relates to the fields of traditional Chinese medicine science and medicines, and especially relates to a medicine for treating spondylodynia and hyperosteogeny, and a preparation method thereof. The medicine is an external preparation prepared from rhizoma drynariae, Achyranthes bidentata, panax notoginseng, Aconitum kusnezoffii and ginger, and preferably is a vinum, a paste, an ointment and a film agent. Clinical test confirms that the medicine has a very good therapeutic effect on hyperosteogeny, cervical spondylosis and various types of spondylodynia, and has the advantages of wide application range, safety in use, and very low treatment cost.

The present application discloses an extra-articular universal locking plate for the proximal end of the femur, which includes a body for fixing the proximal end of the fracture and a head for fixing the distal end of the fracture, the head and the body are integrated, the The body is bent to form a certain arc in the plane where it is located, and a plurality of coupling holes are distributed in an array on the body, and the head is concave, and two locking holes are opened on it. The extra-articular universal locking plate of the proximal femur provided by the new model has simple structure and high safety, and is suitable for clinical needs. Screwing in can achieve the purpose of connecting bones more firmly. In addition, there is a universal small hole on the inner wall of the threaded hole, which can have strong fixation and make the bone heal faster.

The invention provides a fusion locking plate and a wrist fusion structure, which relate to the technical field of medical instruments and solve the problems of long time required for plate fixation and poor fixation stability in the fracture treatment process. The fusion locking plate comprises a bone plate, a plurality of positioning holes are arranged along the thickness direction of the bone plate, and a plurality of anti-skid protrusions are arranged on one side of the bone plate. The fusion locking plate is provided with an anti-skid protrusion, the friction force between the fusion locplate and the part to be fixed is large in the fixing process, the displacement is not liable to occur, the fixing part is convenient to install, and the fusion loc plate is more stable after fixing.

The invention provides a tumor cell heterogeneic transplantation zebrafish model, a construction method and application thereof. By implanting primary cells separated from a tumor tissue of a patientinto a zebrafish, the tumor heterogeneic transplantation model derived from the patient is obtained. According to the established tumor heterogeneic transplantation model, pathological characteristicsof human gastric cancer tissue in clinic are preserved, higher clinical correlation is achieved, the established tumor heterogeneic transplantation model can be used for systematically studying the mechanism of tumor proliferation, metastasis, diffusion and drug resistance, and tumor therapeutic drugs are effectively screened.

The invention relates to the field of natural medicine, in particular to compound phytolectin and a preparation method and application thereof. The compound phytolectin is prepared from pseudo-ginseng, eucommia ulmoides, root of kudzu vine, rehmannia, root of red-rooted salvia, kelp and silverweed cinquefoil root leaves, wherein the compound phytolectin contains the components of salvianic acid, salvia miltiorrhiza flavones, notoginsenoside, rehmannia saponin, rehmannin, laminaran, pueraria flavones and eucommia ulmoides terpene. Pharmacological experiments prove that the compound phytolectinhas an ideal therapeutical effect for hypertension, when the compound phytolectin is cooperatively used with hypotensive drugs, the antihypertensive efficacy is further strengthened and is obviously superior to exclusive use of hypotensive drugs, and the toxic and side effects such as edema of hypotensive drugs after cooperative use are greatly reduced. Moreover, the compound phytolectin is a natural preparation, is safe and reliable to use, is applicable for various types of hypertension patients, and is extremely suitable for current clinical requirements.

Belonging to the field of drugs, the invention in particular relates to a pharmaceutical composition for treatment of cerebral ischemic stroke. The pharmaceutical composition is prepared from a bacopamonnieri extract, a distylium racemosum leaf extract, kalanchoe tomentosa powder, citicoline, nattokinase, and vinpocetine, and is preferably tablets, capsules, pills, granules, powder and suspensions. Pharmacodynamics experiments prove that the pharmaceutical composition provided by the invention has good therapeutic effect on cerebral ischemic stroke at convalescent period, and has the advantages of simple formula, easily controllable quality, good safety and low treatment cost, is suitable for various cerebral ischemic stroke patients, and is very suitable for current clinical needs.

The invention relates to an L-oxiracetam oral instant membrane, which is prepared from 3 to 20 parts of L-oxiracetam, 40 to 70 parts of membrane-forming material, 10 to 30 parts of filter, 5 to 20 parts of plasticizer and 2 to 4 parts of corrigent, wherein the membrane-forming material is maltodextrin. The L-oxiracetam oral instant membrane can be dissolved by a small amount of saliva in the oral cavity, and can be taken without water for delivery, so administration is convenient. After being stuck to the tongue, the L-oxiracetam oral instant membrane cannot be easily spit out, and therefore is suitable for children with dysphagia. Moreover, because the L-oxiracetam oral instant membrane can be absorbed through the mucous membrane, the first pass elimination effect is prevented, the bioavailability is increased, the dosage of medication is reduced, and thereby the side effect of the medicine is reduced. A preparation method of the invention is simple, the process cost is low, and therefore the preparation method is suitable for mass production.

The invention discloses a medical nanofiber-reinforced hydrophilic composite material and its preparation method and application. The composite material is composed of a hydrophilic base material and nano-short fibers, and the nano-short fibers maintain a crystalline form and are uniformly dispersed on the hydrophilic base. In the material, the mass percentage of the nano-short fiber in the composite material is 1%~30%; the diameter of the nano-short fiber is 200~800nm, and the length is 10~100 μm; the preparation method of the medical nanofiber reinforced composite material of the present invention, The process design is unique, using the solubility difference between the base material and nano-short fibers to evenly disperse the nano-short fibers in the base material, and use the freeze-drying method to obtain a porous sponge-like composite material, which maintains the respective advantages of the two materials. Complementing the disadvantages, a composite material with excellent mechanical properties, good biocompatibility, and good biodegradability is obtained. Its degradation cycle is moderate, and it will not cause postoperative inflammation and postoperative risk of adhesion, which is more suitable for clinical needs. .

The invention relates to an L-oxiracetam oral instant membrane, which is prepared from 3 to 20 parts of L-oxiracetam, 40 to 70 parts of membrane-forming material, 10 to 30 parts of filter, 5 to 20 parts of plasticizer and 2 to 4 parts of corrigent, wherein the membrane-forming material is maltodextrin. The L-oxiracetam oral instant membrane can be dissolved by a small amount of saliva in the oral cavity, and can be taken without water for delivery, so administration is convenient. After being stuck to the tongue, the L-oxiracetam oral instant membrane cannot be easily spit out, and therefore is suitable for children with dysphagia. Moreover, because the L-oxiracetam oral instant membrane can be absorbed through the mucous membrane, the first pass elimination effect is prevented, the bioavailability is increased, the dosage of medication is reduced, and thereby the side effect of the medicine is reduced. A preparation method of the invention is simple, the process cost is low, and therefore the preparation method is suitable for mass production.

The present application discloses an inverted femoral intramedullary nail, which is used for internal fixation of femoral shaft fractures, comprising a rod body that matches the shape of the femoral shaft, and the rod body includes a first rod body at the distal end and a second rod body at the proximal end, The first rod body and the second rod body are axially integrated, and the first rod body is sequentially provided with an 8-shaped first fixing hole from the distal end to the proximal end direction, a second fixing hole matched with a locking screw, and A long waist-shaped third fixing hole matched with the compression screw, three round holes and a long waist hole are opened on the second rod body. The inverted femoral intramedullary nail provided by the present invention is simple in structure and high in safety, and is suitable for clinical needs. The intramedullary nail has high tensile strength, can be used for femoral shaft fractures, and can achieve the purpose of small surgical incision and fast and convenient surgery.

The invention relates to the field of natural medicine, in particular to compound phytolectin and a preparation method and application thereof. The compound phytolectin is prepared from pseudo-ginseng, eucommia ulmoides, root of kudzu vine, rehmannia, root of red-rooted salvia, kelp and silverweed cinquefoil root leaves, wherein the compound phytolectin contains the components of salvianic acid, salvia miltiorrhiza flavones, notoginsenoside, rehmannia saponin, rehmannin, laminaran, pueraria flavones and eucommia ulmoides terpene. Pharmacological experiments prove that the compound phytolectinhas an ideal therapeutical effect for hypertension, when the compound phytolectin is cooperatively used with hypotensive drugs, the antihypertensive efficacy is further strengthened and is obviously superior to exclusive use of hypotensive drugs, and the toxic and side effects such as edema of hypotensive drugs after cooperative use are greatly reduced. Moreover, the compound phytolectin is a natural preparation, is safe and reliable to use, is applicable for various types of hypertension patients, and is extremely suitable for current clinical requirements.

The invention relates to the field of medicine for external use, in particular to an analgesic for external use and a preparation method thereof. The external analgesic of the present invention is composed of menthol, bamboo cypress extract, capsaicin, dimethyl sulfoxide, green skewer extract, winter green oil, turpentine, calendula oil, hypericum oil, camphor, dimethyl sulfone , ginger and olive oil. In the present invention, through formula improvement, menthol, capsaicin, dimethyl sulfoxide, wintergreen oil, turpentine and other ingredients are synergistically coordinated, and on this basis, bamboo and cypress extract and green skewer extract prepared by a specific process are added, and the resulting The prepared external analgesic can quickly permeate into the pain site through the skin, effectively block the pain signal transmission, and realize the effect of rapid pain relief. Pharmacological tests prove that the external analgesic of the present invention has an ideal therapeutic effect on peripheral pain, and the product of the present invention has rapid onset of action, convenient use and good safety, and is very suitable for current clinical needs.

The invention discloses an ulna intramedullary nail which comprises a first nail body and a second nail body which are coaxially connected. The diameter of the first nail body is larger than that of the second nail body. Three parallel fixing holes are formed in the first nail body and perpendicular to the axial direction of the first nail body. An external thread surface is formed at the portion, close to the tail end, of the second nail body. The ulna intramedullary nail is simple in structure, high in safety, suitable for meeting clinical requirements and high in tensile strength, and since the ulna intramedullary nail is implanted in a medullary space to be fixed, the aims of being small in wounds and stable in fixation can be achieved; in addition, a far end thread is screwed in the medullary space, and a near end conducts pressurizing through equipment, so a bone can be more rapidly cured.

The invention relates to the technical field of medical equipment, in particular to a scapular locking plate and a scapular locking method. The scapular locking plate comprises a first plate portion and a second plate portion, wherein the first plate portion is connected with the second plate portion, and the first plate portion is angularly disposed with the second plate portion; The first plateportion is used for fixing to the lateral edge of the scapula, and the second plate portion is used for fixing to the scapular neck of the scapula. A method for loc that scapula includes fix a first plate part at the lateral edge of the scapula and fixing a second plate part at the neck of the scapula, wherein the first plate part and the second plate part are angularly arranged, and the first plate part and the second plate part are both positioned behind the scapula. The invention can meet the clinical needs, reduce the surgical incision, thereby reducing the mobile phone risk and reducing the incidence of a plurality of complications.

The invention relates to the field of traditional Chinese pharmacology, in particular to a medicine for treating rheumatoid and a preparation method thereof. The medicine is prepared from the following raw materials of wild fungi pine lucid ganoderma, fomitopsis pinicola, laricifomes officinalis, polyporus, ganoderma applanatum, chaga, trametes orientalis, piptoporus betulinus, ganoderma lucidum,and pyropolyporus fomentarius, and geo-authentic crude drugs of radix aconiti, radix aconiti agrestis, rhizoma gastrodiae, radix notoginseng, herba asari, radix stephaniae tetrandrae, radix saposhnikoviae, rhizoma et radix notopterygii, radix angelicae pubescentis, radix gentianae macrophyllae, semen strychni, lumbricus, fructus chaenomelis, scorpion, centipede, ramulus mori, radix cyathulae, rhizoma chuanxiong, rhizoma atractylodis, cortex cinnamomi, radix aconiti carmichaeli, radix clematidis, caulis sinomenii and minium, wherein the raw materials are decocted by cannabis oil, so as to obtain an external ointment. Proofed by clinical test, the medicine has the advantages that the ideal treatment function on the rheumatoid is realized; the poor reaction is little, the safety property is good, the convenience in use is realized, and the tolerance and obedience of a patient are high.

The present invention relates to human tissue kallikrein, and is especially the microcapsulized cell of human tissue kallikrein and its microcapsulizing method and application. On the cell of expressing human tissue kallikrein for gene modification, rigid envelope material with bi-directional flowability is coated. The human tissue kallikrein is suitable for application in treating hypertension and kidney diseases. The present invention has the obvious advantages of adaptability to practical clinical application, obvious application effect and feasible method.

The invention provides a medical instrument bone plate, and belongs to the field of medical instruments for orthopedics. The bone plate includes a strip plate. Multiple threaded holes are arranged inthe center line of the strip plate. A left fixing plate is movably connected to one side of the strip plate. A right fixing plate is movably connected to the other side of the strip plate. The cross sections of the left fixing plate and the right fixing plate are of an arc structure. A fixing column is arranged on the lower edge of the left fixing plate. The end part of the fixing column is provided with an external thread. The lower edge of the right fixing plate is provided with a clamping groove matching the fixing column. The fixing column is fixed in the clamping groove through a nut. Themedical instrument bone plate is simple in structure and high in safety, is suitable for clinic demands, adopts an arc design on the surface, and can fit well with phalanges. Through the arrangementof the left fixing plate and the right fixing plate on the two sides of the strip plate, the bone plate can be prevented from displacement, and so bones can be connected more firmly and a fracture canbe healed more quickly and easily.

The invention belongs to the field of drugs, and particularly relates to a pharmaceutical composition for treating senile macular degeneration. The pharmaceutical composition is prepared from vitaminC, a distylium racemosum leaf extract, hyaluronic acid, vitamin E, xanthophyll, astaxanthin, zinc oxide, zeaxanthine and copper gluconate, and is preferably prepared into tablets, capsules, pills, granules, powder and suspensions. A pharmacodynamic experiment proves that the pharmaceutical composition has a better therapeutical effect on the senile macular degeneration, is good in safety and low in therapeutical cost, and is very suitable for the current clinical demands.

The invention provides an operative bone drill, belongs to the technical field of medical instruments, and aims at solving the problem that a traditional open type bone taking operation mode is single, and the damage to a patient is large. The bone drill comprises a handle, a connector, a locking screw, movable teeth, a drill rod and an adjusting sealing cap. The locking screw is fixedly arrangedon the handle; the connector is fixedly arranged at one end of the locking screw; one end of the drill rod is integrally provided with a ratchet wheel, and the other end is provided with sawteeth; thedrill rod is movably arranged on the connector, and the ratchet wheel is located in the connector; and the movable teeth are hinged in the connector, and a ratchet matched with the ratchet wheel is integrally arranged on the movable teeth. The bone drill is simple in design and operation, high in safety, high in stability and suitable for clinical requirements, and achieves the purposes of smallsurgical incision and convenience and quickness in surgery.