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Analgesic for external use and preparation method thereof

A technology for external use of analgesics and extracts, applied in the field of external drugs, can solve the problems of many adverse reactions, unsatisfactory effects, low safety, etc., and achieve the effects of good safety, blocking pain signal transmission, and rapid onset of action

Active Publication Date: 2021-07-13
ANHUI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to overcome the defects of slow onset of action, unsatisfactory effect, many adverse reactions, and low safety of existing externally used analgesic drugs, the present invention provides a drug that is safe in use, wide in application, rapid in effect, definite in curative effect, and low in cost. topical analgesics

Method used

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  • Analgesic for external use and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] An analgesic for external use is made from the following raw materials in parts by weight:

[0032] Menthol 12, bamboo cypress extract 15, capsaicin 0.2, dimethyl sulfoxide 20, green skewer extract 10, winter green oil 10, turpentine oil 10, calendula oil 5, hypericum oil 5, camphor 0.8, two Methylsulfone 1, Ginger Oil 1, Olive Oil 1.

[0033] The preparation method is as follows:

[0034] (1) Preparation of bamboo and cypress extract: remove impurities from bamboo and cypress leaves, wash, dry and crush, add 4 times the amount of isobutanol, soak for 2 hours and filter, discard the filtrate, dry the filter residue and add 10 times the amount therein Acetic acid aqueous solution with a volume concentration of 0.6%, soaked for 1 hour, decocted for 0.5 hour, filtered the liquid medicine, and the filtrate was used for later use. Under the same conditions, the filter residue was repeatedly extracted once, filtered, and the filtrates were combined twice, and concentrated un...

Embodiment 2

[0038] An analgesic for external use is made from the following raw materials in parts by weight:

[0039] Menthol 10, bamboo and cypress extract 12, capsaicin 0.18, dimethyl sulfoxide 18, green skewer extract 8, winter green oil 8, turpentine oil 8, calendula oil 4.5, hypericum oil 4.5, camphor 0.65, two Methyl sulfone 0.9, ginger oil 0.9, olive oil 0.8.

[0040]The preparation method is the same as in Example 1.

Embodiment 3

[0042] An analgesic for external use is made from the following raw materials in parts by weight:

[0043] Menthol 13, bamboo cypress extract 16, capsaicin 0.25, dimethyl sulfoxide 22, green skewer extract 12, winter green oil 12, turpentine oil 12, calendula oil 5.5, hypericum oil 5.5, camphor 0.9, di Methyl sulfone 1.2, ginger oil 1.2, olive oil 1.5.

[0044] The preparation method is the same as in Example 1.

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Abstract

The invention relates to the field of medicine for external use, in particular to an analgesic for external use and a preparation method thereof. The external analgesic of the present invention is composed of menthol, bamboo cypress extract, capsaicin, dimethyl sulfoxide, green skewer extract, winter green oil, turpentine, calendula oil, hypericum oil, camphor, dimethyl sulfone , ginger and olive oil. In the present invention, through formula improvement, menthol, capsaicin, dimethyl sulfoxide, wintergreen oil, turpentine and other ingredients are synergistically coordinated, and on this basis, bamboo and cypress extract and green skewer extract prepared by a specific process are added, and the resulting The prepared external analgesic can quickly permeate into the pain site through the skin, effectively block the pain signal transmission, and realize the effect of rapid pain relief. Pharmacological tests prove that the external analgesic of the present invention has an ideal therapeutic effect on peripheral pain, and the product of the present invention has rapid onset of action, convenient use and good safety, and is very suitable for current clinical needs.

Description

technical field [0001] The invention relates to the field of medicine for external use, in particular to an analgesic for external use and a preparation method thereof. Background technique [0002] Analgesics refer to drugs that can relieve pain partially or completely, mainly including non-steroidal anti-inflammatory drugs and central analgesics. According to different routes of administration, analgesics can be divided into oral analgesics and topical analgesics. Currently, commonly used topical analgesics include Voltaren ointment, ibuprofen ointment, diclofenac sodium ointment, Yunnan Baiyao, and traditional Chinese medicine ointment. Muscle and joint pain, sports sprains, and pain caused by various types of inflammation. [0003] However, the above-mentioned various types of drugs still show many deficiencies in the clinical application process. For example, although the non-steroidal anti-inflammatory drugs have a rapid onset of action, they have many adverse reactio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9068A61P29/00A61K31/045A61K31/125A61K31/165A61K31/618
CPCA61K9/0014A61K31/045A61K31/125A61K31/165A61K31/618A61K36/15A61K36/28A61K36/32A61K36/38A61K36/9068A61K2236/331A61K2236/53A61P29/00A61K2300/00
Inventor 李长润于小利
Owner ANHUI UNIVERSITY
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