Medical nano fiber enhanced composite material and preparation method thereof

A technology of composite materials and nanofibers, which is applied in the field of medical nanofiber-reinforced composite materials and its preparation, which can solve the difficulty of meeting the requirements of mechanical properties and biodegradability of materials, composition ratio, segment distribution, and difficult stable control of molecular weight , can not fully meet the clinical needs of medical polymer materials, etc., to achieve good biodegradability, good biocompatibility, and enhanced mechanical properties

A technology of composite materials and nanofibers, which is applied in the field of medical nanofiber-reinforced composite materials and its preparation, which can solve the difficulty of meeting the requirements of mechanical properties and biodegradability of materials, composition ratio, segment distribution, and difficult stable control of molecular weight , can not fully meet the clinical needs of medical polymer materials, etc., to achieve good biodegradability, good biocompatibility, and enhanced mechanical properties

CN107815079AActive Publication Date: 2018-03-20SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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  • Medical nano fiber enhanced composite material and preparation method thereof

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preparation example Construction

[0032] The present invention also includes a preparation method of medical nanofiber-reinforced composite material, comprising the following steps:

[0033] ① Vacuum-dry the polyester material at 100°C for 24 hours. Under the protection of nitrogen, put it in the screw of the spinning device to melt it. Under the voltage of 8~30KV, extrude and spin the filament at a constant speed. After receiving it in the vortex cooling liquid tank, the diameter 1-10 μm polyester fiber bundle; the polyester material is polyglycolide or polylactide;

[0034] ②Under the protection of nitrogen, heat-stretch the polyester fiber bundle obtained in step ① twice, each stretching ratio is 5-8 times, to obtain nanofibers with a diameter of 200-800nm;

[0035] When the material of the polyester fiber bundle obtained in step 1 is polyglycolide, the temperatures of the two thermal stretches are respectively 180°C and 160°C; The stretching temperatures are 150°C and 130°C respectively;

[0036] ③ The n...

Embodiment 1

[0049] A medical nanofiber-reinforced composite material, the composite material is composed of basic materials and short nanofibers, the short nanofibers maintain a crystalline form and are uniformly dispersed in the basic material, and the mass percentage of short nanofibers in the composite material is 10%; The base material is polydioxanone; the nano-short fiber is a polyester material, and the polyester material is polyglycolide; the diameter of the nano-short fiber is 200 nm, and the length is 10 μm.

Embodiment 2

[0051] A medical nanofiber-reinforced composite material, the composite material is composed of base material and nano-short fibers, the nano-short fibers maintain a crystalline form and are uniformly dispersed in the base material, and the mass percentage of nano-short fibers in the composite material is 50%; The base material is polytrimethylene carbonate; the nano-short fiber is a polyester material, and the polyester material is polylactide; the diameter of the nano-short fiber is 800 nm, and the length is 100 μm.

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Abstract

The invention relates to a medical nano fiber enhanced composite material. The composite material comprises a base material and nano short fiber, wherein the nano short fiber keeps a crystal form andis uniformly distributed in the base material, and the nano short fiber accounts for 1-50 mass percent of the composite material. The composite material has the advantage that a single-component polymer material has high break elongation and high flexibility, has little damage to blood vessels and other tissues, has high tensile strength and high break elongation in human tissues, and greatly improves the tensile strength of the material. The medical nano fiber enhanced composite material has high biocompatibility and biodegradability, and can meet clinical demands of medical materials.

Description

technical field [0001] The invention relates to the technical field of nanofiber composite materials, in particular to a medical nanofiber reinforced composite material and a preparation method thereof. Background technique [0002] Various tissues and organs in the human body may be abnormal or damaged. At present, the transplantation of tissues and organs is mainly used to restore their functions. In this process, a large amount of biological materials are needed to support the normal work of tissues and organs, such as stents, Ligation clips, etc., materials with good biocompatibility and biodegradability can finally form new functional tissues with the further proliferation and differentiation of cells and the degradation and absorption of materials to achieve the purpose of repairing defective tissues. The demand in the market is also increasing. [0003] Medical materials prepared from single-component polymer raw materials have high elongation at break, good flexibil...

Claims

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Application Information

Patent Timeline
20 Mar 2018
Publication
CN107815079A
IPC
C08L67/04; C08L69/00; C08J5/04
CPC
C08J5/046; C08J2367/04; C08J2369/00; C08J2467/04
Inventors
刘阳; 王宪朋