Pharmaceutical composition for treatment of cerebral ischemic stroke

A composition and drug technology, applied in the directions of drug combination, pharmaceutical formula, plant raw materials, etc., can solve the problems of difficult production process, aggravating disease, complex composition, etc., and achieve good safety, good therapeutic effect, and low treatment cost. Effect

Inactive Publication Date: 2019-02-01
安徽省科学技术研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned drugs all have high risks during use, such as diuretics can easily lead to dehydration, electrolyte imbalance, and rebound after drug withdrawal; adrenal cortex hormones have many and serious adverse reactions; human serum albumin can cause dehydration , body circulation overload, congestive heart failure and pulmonary edema; kinase drugs can easily cause bleeding and allergies; improper use of anticoagulants can easily cause bleeding and aggravate the condition
In addition to the above-mentioned drugs, there are currently some traditional Chinese medicine compound preparations used for the treatment of cerebral infarction in the convalescent period, but most of them are slow to take effect and the curative effect is not significant. The quality control of the product has caused great difficulties, and it is not conducive to maintaining the stability of product quality. In addition, taking traditional Chinese medicine requires syndrome differentiation and treatment, and taking it randomly will not work well and even aggravate the condition
[0004] In summary, the inherent defects of existing cerebral infarction drugs have greatly reduced the tolerance and compliance of patients

Method used

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  • Pharmaceutical composition for treatment of cerebral ischemic stroke

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A pharmaceutical composition for treating cerebral infarction, the pharmaceutical composition is made of the following raw materials in parts by weight:

[0039] Bacopa monniera extract 360, Mosquito leaf extract 310,

[0040] Brown Spot Kalanchoe Powder 125, Citicoline 500,

[0041] Nattokinase 100, Vinpocetine 10.

[0042] The preparation method is as follows:

[0043] (1) After rinsing, drying and pulverizing Bacopa monnieri, add 10 times the amount of 30% ethanol, soak for 2 hours and then reflux for extraction for 1 hour, filter the medicinal solution, and use the filtrate for later use. Repeat the extraction of the filter residue once under the same conditions. Filtrate, combine the filtrates, concentrate under reduced pressure to a small volume and then spray dry to obtain Bacopa monniera extract;

[0044] (2) After rinsing, drying, and crushing the leaves of Mosquito, add 5 times the amount of petroleum ether, soak for 2 hours, vacuum filter, discard the filt...

Embodiment 2

[0048] A pharmaceutical composition for treating cerebral infarction, the pharmaceutical composition is made of the following raw materials in parts by weight:

[0049] Bacopa monniera extract 300, Mosquito leaf extract 300,

[0050] Brown Spot Kalanchoe Powder 120, Citicoline 470,

[0051] Nattokinase 90, Vinpocetine 9.

[0052] The preparation method is as follows:

[0053] (1) After rinsing, drying and pulverizing Bacopa monnieri, add 9 times the amount of 30% ethanol, soak for 2 hours, then reflux for extraction for 1 hour, filter the medicinal solution, and use the filtrate for later use. Repeat the extraction of the filter residue once under the same conditions. Filtrate, combine the filtrates, concentrate under reduced pressure to a small volume and then spray dry to obtain Bacopa monniera extract;

[0054](2) After rinsing, drying, and crushing the leaves of Mosquito, add 5 times the amount of petroleum ether, soak for 2 hours, vacuum filter, discard the filtrate, a...

Embodiment 3

[0058] A pharmaceutical composition for treating cerebral infarction, the pharmaceutical composition is made of the following raw materials in parts by weight:

[0059] Bacopa monniera extract 450, Mosquito leaf extract 325,

[0060] Brown Spot Kalanchoe Powder 130, Citicoline 510,

[0061] Nattokinase 105, Vinpocetine 12.

[0062] The preparation method is as follows:

[0063] (1) After rinsing, drying and pulverizing Bacopa monniera, add 8 times the amount of 30% ethanol, soak for 2 hours and then reflux for 1 hour, filter the medicinal solution, and use the filtrate for later use. Repeat the extraction of the filter residue once under the same conditions. Filtrate, combine the filtrates, concentrate under reduced pressure to a small volume and then spray dry to obtain Bacopa monniera extract;

[0064] (2) After rinsing, drying, and crushing the leaves of Mosquito, add 5 times the amount of petroleum ether, vacuum filter after soaking for 2 hours, discard the filtrate, an...

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Abstract

Belonging to the field of drugs, the invention in particular relates to a pharmaceutical composition for treatment of cerebral ischemic stroke. The pharmaceutical composition is prepared from a bacopamonnieri extract, a distylium racemosum leaf extract, kalanchoe tomentosa powder, citicoline, nattokinase, and vinpocetine, and is preferably tablets, capsules, pills, granules, powder and suspensions. Pharmacodynamics experiments prove that the pharmaceutical composition provided by the invention has good therapeutic effect on cerebral ischemic stroke at convalescent period, and has the advantages of simple formula, easily controllable quality, good safety and low treatment cost, is suitable for various cerebral ischemic stroke patients, and is very suitable for current clinical needs.

Description

technical field [0001] The invention belongs to the field of medicines, in particular to a pharmaceutical composition for treating cerebral infarction. Background technique [0002] Cerebral infarction, also known as ischemic stroke or cerebral ischemic stroke, refers to localized ischemic necrosis or softening of brain tissue caused by cerebral blood supply disturbance, ischemia and hypoxia. Its clinical manifestations are characterized by sudden fainting, unconsciousness, hemiplegia, speech impairment, and mental retardation. The common clinical types of cerebral infarction include cerebral thrombosis, lacunar infarction, and cerebral embolism. Cerebral infarction accounts for 80% of all strokes. Great pain and heavy burden. [0003] The drug treatment in the acute phase and recovery phase of cerebral infarction mainly includes diuretic therapy and thrombolytic therapy. Diuretic therapy mostly uses dehydrating agents mannitol, glycerol fructose, furosemide, etc., as well...

Claims

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Application Information

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IPC IPC(8): A61K38/48A61P9/10A61K36/80A61K31/7068A61K31/4375
CPCA61K31/4375A61K31/7068A61K36/185A61K36/41A61K36/80A61K38/482A61K2236/333A61K2236/39A61K2236/51A61P9/10C12Y304/21062A61K2300/00
Inventor 韦一玉李长润
Owner 安徽省科学技术研究院
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