Pharmaceutical composition for treating senile macular degeneration

A technology of macular degeneration and composition, which is applied in the direction of drug combination, effective ingredients of hydroxyl compounds, and pharmaceutical formulations, can solve the problems of high risk of treatment, slow onset of effect, and insignificant curative effect, and achieve good therapeutic effect, low treatment cost, and good safety effect

Inactive Publication Date: 2019-03-01
ANHUI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned treatment methods still have many defects, for example: laser therapy cannot prevent recurrence, and fundus fluorescein angiography is required before each treatment, so the use is limited; surgical treatment is invasive treatment, treatment risk is high, and treatment costs Higher; anti-VEGF monoclonal antibody is expensive, and the risk of treatment is higher; antioxidant drugs and trace element preparations are more focused on preventing the occurrence of diseases. slow, and the curative effect is not significant, so far, in modern medicine has not yet found a definite and effective drug therapy that can prevent the progression of the disease

Method used

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  • Pharmaceutical composition for treating senile macular degeneration
  • Pharmaceutical composition for treating senile macular degeneration
  • Pharmaceutical composition for treating senile macular degeneration

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A pharmaceutical composition for treating age-related macular degeneration, the pharmaceutical composition is made of the following raw materials in parts by weight:

[0027]

[0028] The preparation method is as follows:

[0029] (1) After rinsing, drying, and crushing the leaves of Mosquito, add 5 times the amount of petroleum ether, vacuum filter after soaking for 2 hours, discard the filtrate, and add 10 times the amount of ethanol: acetone: ethyl acetate to the filter residue = 6:2:1.5 mixed solution, soak for 1 hour, reflux for extraction for 1 hour, filter the liquid medicine, and use the filtrate for later use. Repeat the extraction of the filter residue once under the same conditions, filter, combine the two filtrates, and concentrate under reduced pressure to a small volume. Spray-dried to obtain the extract of the leaves of Mosquito;

[0030] (2) Mix vitamin C, hyaluronic acid, vitamin E, lutein, astaxanthin, zinc oxide, zeaxanthin, copper gluconate and t...

Embodiment 2

[0032] A pharmaceutical composition for treating age-related macular degeneration, the pharmaceutical composition is made of the following raw materials in parts by weight:

[0033]

[0034] The preparation method is as follows:

[0035] (1) After rinsing, drying, and crushing the leaves of Mosquito, add 5 times the amount of petroleum ether, vacuum filter after soaking for 2 hours, discard the filtrate, and add 10 times the amount of ethanol: acetone: ethyl acetate to the filter residue = 6:2:1.5 mixed solution, soak for 1 hour, reflux for extraction for 1 hour, filter the liquid medicine, and use the filtrate for later use. Repeat the extraction of the filter residue once under the same conditions, filter, combine the two filtrates, and concentrate under reduced pressure to a small volume. Spray-dried to obtain the extract of the leaves of Mosquito;

[0036] (2) Take dried eucalyptus leaves and add 10 times the amount of water after crushing, soak for 1 hour, decoct for ...

Embodiment 3

[0039] A pharmaceutical composition for treating age-related macular degeneration, the pharmaceutical composition is made of the following raw materials in parts by weight:

[0040]

[0041] The preparation method is the same as in Example 1.

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Abstract

The invention belongs to the field of drugs, and particularly relates to a pharmaceutical composition for treating senile macular degeneration. The pharmaceutical composition is prepared from vitaminC, a distylium racemosum leaf extract, hyaluronic acid, vitamin E, xanthophyll, astaxanthin, zinc oxide, zeaxanthine and copper gluconate, and is preferably prepared into tablets, capsules, pills, granules, powder and suspensions. A pharmacodynamic experiment proves that the pharmaceutical composition has a better therapeutical effect on the senile macular degeneration, is good in safety and low in therapeutical cost, and is very suitable for the current clinical demands.

Description

technical field [0001] The invention belongs to the field of medicines, in particular to a medicine composition for treating age-related macular degeneration. Background technique [0002] Age-related macular degeneration, also known as age-related macular degeneration, is a fundus disease related to multi-factorial effects of age. The older the age, the higher the prevalence. In western countries, macular degeneration is the main cause of blindness in people over 50 years old. In my country, the incidence of macular degeneration is also increasing. According to statistics, the incidence rate of people aged 60-69 in my country is 6.04-11.19%. With the acceleration of population aging, the incidence of this disease has a clear upward trend. [0003] Age-related macular degeneration is clinically divided into atrophic type (dry type) and exudative type (wet type). Since the etiology is not completely clear, the treatment methods for the etiology still need further research. T...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/61A61K36/185A61P27/02A61K31/047A61K31/122A61K31/355A61K31/375A61K31/728A61K33/30A61K33/34
CPCA61K31/047A61K31/122A61K31/355A61K31/375A61K31/728A61K33/30A61K33/34A61K36/185A61K36/61A61K2236/331A61K2236/333A61K2236/39A61P27/02A61K2300/00
Inventor 李长润韦一玉
Owner ANHUI UNIVERSITY
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