A kind of levoxiracetam oral fast-dissolving film and preparation method thereof

An oral instant film and flavoring technology, applied in the field of oxiracetam, can solve the problems of difficult control of disintegration time and tensile strength, restricting the development and application of oral film, complex liposome preparation process, etc. , to solve the mutual adhesion of film agents, improve bioavailability, and avoid elimination effects.
CN106821959BActive Publication Date: 2018-10-23CHONGQING RUNZE PHARM CO LTD
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Patents(China)
Current Assignee / Owner
CHONGQING RUNZE PHARM CO LTD
Publication Date
2018-10-23

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Abstract

The invention relates to an L-oxiracetam oral instant membrane, which is prepared from 3 to 20 parts of L-oxiracetam, 40 to 70 parts of membrane-forming material, 10 to 30 parts of filter, 5 to 20 parts of plasticizer and 2 to 4 parts of corrigent, wherein the membrane-forming material is maltodextrin. The L-oxiracetam oral instant membrane can be dissolved by a small amount of saliva in the oral cavity, and can be taken without water for delivery, so administration is convenient. After being stuck to the tongue, the L-oxiracetam oral instant membrane cannot be easily spit out, and therefore is suitable for children with dysphagia. Moreover, because the L-oxiracetam oral instant membrane can be absorbed through the mucous membrane, the first pass elimination effect is prevented, the bioavailability is increased, the dosage of medication is reduced, and thereby the side effect of the medicine is reduced. A preparation method of the invention is simple, the process cost is low, and therefore the preparation method is suitable for mass production.
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Description

Technical field

[0001] The invention relates to an oxiracetam, in particular to a levo-oxiracetam oral instant film and a preparation method thereof. Background technique

[0002] Oxiracetam, whose chemical name is 4-hydroxy-2-oxo-1-pyrrolidine acetamide, is a nootropic drug first synthesized in 1974 by the Italian company Smith Kbeechem. It is a hydroxyl group GABA (GABOB) derivatives, a central nervous system drug that can promote learning, enhance memory, and protect damaged nerve cells. Its structure is as follows:

[0003]

[0004] CN102552125A announced that it can improve memory and the memory and learning function of patients with intellectual disability; it is also suitable for memory and intellectual disability caused by mild to moderate vascular dementia, senile dementia, and brain trauma, or as an auxiliary treatment drug. CN102600130A discloses its new clinical application for treating epilepsy. At present, clinically, Oxiracetam is mainly available in injections, ca...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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