Chinese medicinal granule and preparation method thereof

Abstract

The invention discloses a Chinese medicinal granule and a preparation method thereof. The Chinese medicinal granule is prepared from the following components: traditional Chinese medicine dry powder,polyethylene glycol and micropowder silica gel. Meanwhile, the invention further provides another Chinese medicinal granule which is prepared from traditional Chinese medicine dry powder, a filling agent, polyethylene glycol and micropowder silica gel. The invention also provides a preparation method of the Chinese medicinal granule, and dry granulation is adopted for the method. The inventor, bymultiple times of repeated tests and constant exploration, finds that after adding polyethylene glycol to the Chinese medicinal granule as a lubricant, an adhesive and a cosolvent and performing dosage screening, improvement of one-time forming property, guarantee on the granularity and medicine loading capacity are all obviously promoted in comparison with conventional accessory proportion.

Description

technical field [0001] The invention belongs to the field of pharmacy, and specifically relates to a prescription of traditional Chinese medicine formula granules prepared by dry granulation and a process thereof. Background technique [0002] Traditional Chinese medicine formula granules are granules made by extracting and concentrating single-flavored Chinese medicine decoction pieces, and are used for clinical formulas of traditional Chinese medicine. [0003] The active ingredients, nature, taste, meridian distribution, indications, and efficacy of traditional Chinese medicine formula granules are exactly the same as those of traditional Chinese medicine decoction pieces. The feature of reducing weight is better than that of Chinese patent medicine, and it saves the trouble of traditional decoction for patients. At the same time, it can be flexibly taken with single-flavor granules, which is hygienic and effective. [0004] In recent years, Chinese medicine formula gran...

AI Technical Summary

Problems solved by technology

[0014] 1. The material is highly viscous and poor compressibility leads to great differences in particle formability; some decoction pieces and extracts can be directly compressed to make granules, and a large part of traditional Chinese medicine extracts have poor compressibility and low yield at one time. It needs to be pressed repeatedly, or it can be achieved by increasing the pressure of the equipment

[0015] 2. Part of the formula can suppress normal granules, but the particle size and strength of the granules are poor. During the process of handling and extrusion, the granules are easily crushed and a large amount of fine powder is produced.

[0016] 3. For some highly viscous prescriptions,

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