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SKIN WHITENING COMPOSITION CONTAINING Beta-MANGOSTIN AS ACTIVE INGREDIENT

A technology for mangostin and active ingredients, which is applied in the field of skin whitening compositions containing β-mangostin as an active ingredient, can solve the problems of no disclosure of skin whitening compositions and the like, and achieve the effect of inhibiting the formation of melanin

Active Publication Date: 2018-04-17
IND ACADEMIC COOP FOUND GYEONGSANG NAT UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the skin whitening composition containing β-mangostin derived from mangosteen as an active ingredient of the present invention has not been disclosed yet.

Method used

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  • SKIN WHITENING COMPOSITION CONTAINING Beta-MANGOSTIN AS ACTIVE INGREDIENT

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0082] Example 1. Analysis of cell viability based on β-mangostin (β-mangostin) treatment of the present invention

[0083] In this Example 1, in order to find out the functional plant metabolites that induce depigmentation in melanocytes, from the peel of mangosteen (Garcinia mangostana), three kinds of edible xanthone (xanthone) were isolated and refined. ) series of alpha (α)-, beta (β)- and gamma (γ)-mangostin ( figure 1 ). To confirm the cytotoxicity of the above three xanthone series, B16F10 cells were treated with various concentrations of alpha (α)-, beta (β)- and gamma (γ)-mangostin and incubated for 24 hours . Cell viability was confirmed by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. As a result, such as figure 2 As shown, when dealing with alpha (α)- and gamma (γ)-mangostin, it showed strong cytotoxicity at 20 μM and 40 μM, on the contrary, in the treatment of β-mangostin (β-mangostin) In the case of , no cytotoxicity was shown e...

Embodiment 2

[0084] Embodiment 2. Based on the melanin (melanin) content analysis of the present invention's β-mangostin (β-mangostin) process

[0085] In order to confirm whether β-mangostin (β-mangostin) can inhibit the pigmentation (pigmentation) induced by α-MSH (melanocyte-stimulating hormone), B16F10 cells were treated with α-MSH and β-mangostin and cultured for 72 Hour. As a result, such as image 3 As shown, when only α-MSH was treated, the cell pellets (pellets) turned black, but when treated together with β-mangostin, the color of the cell pellets changed from black to white. That is, β-mangostin suppresses the pigmentation (pigmentation) induced by α-MSH. In addition, the melanin content reduction effects of three xanthone series of alpha (α)-, beta (β)- and gamma (γ)- mangostin were compared. As a result, α-mangostin When treated together with α-MSH, compared with the case of α-MSH alone, the reduction of melanin content was about 20%, while γ-mangostin increased the melanin...

Embodiment 3

[0086] Example 3. Confirmation of proteasome-independent-melanosome elimination effect based on β-mangostin treatment of the present invention

[0087] In order to confirm the whitening effect of β-mangostin, RT-PCR and Western blotting were performed on tyrosinase and TRP-1. As a result, such as Figure 5 As shown, β-mangostin effectively reduces the expression of tyrosinase and TRP-1 induced by α-MSH.

[0088] In order to confirm whether the above-mentioned tyrosinase reduction in B16F10 cells was mediated by the proteasome, the results of treating MG132 as a proteasome inhibitor with the β-mangostin of the present invention were as follows: Figure 6 As shown in (A), in the cells treated with MG132, the expression level of tyrosinase did not increase, and the results of analyzing melanin content and L-DOPA oxidation were as follows: Figure 6 As shown in (B) and (C), there was no effect on melanin production and L-DOPA oxidation. From these results, it was confirmed that...

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Abstract

The present invention relates to a skin whitening composition containing, as an active ingredient, beta-mangostin or a salt thereof, and it has been ascertained that beta-mangostin of the present invention inhibits the expression of tyrosinase and tyrosinase-related protein-1 (TRP-1) and induces melasosome autophagy, thereby inhibiting melanin generation and exhibiting an effect of removing the melanin accumulated because of a melanocyte-stimulating hormone (alpha-MSH). Therefore, beta-mangostin of the present invention could be useful as a functional material for skin whitening and lightening.

Description

technical field [0001] The present invention relates to a skin whitening composition containing β-mangostin as an active ingredient, and more specifically, to a composition having a skin whitening function containing β-mangostin derived from mangosteen as an active ingredient The product is characterized in that, by inhibiting the activity of tyrosinase (tyrosinase) and TRP-1 (tyrosinase-related protein-1), reducing the generation of melanin (melanin) and reducing the melanin produced content. Background technique [0002] In human tissue, the skin is directly exposed to the external environment, and acts as a barrier between the internal environment of the human body and the external environment, defending against the invasion of external pollutants including chemicals, ultraviolet rays, and microorganisms, thereby protecting organisms from encroachment on the surrounding environment. In addition, the color of the skin is determined by melanin, hemoglobin, carotene, etc.,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/49A61K31/352A61K36/38A61K8/02A61K8/9789A61K9/00A61K9/06A61Q19/02
CPCA61Q19/02A61K31/352A61K36/38A61K8/498A23L33/105A61P17/00A61K8/9789A23L29/206A61K8/9783A61K8/022A61K8/042A61K8/06A61K2121/00A61K2800/43A61K2800/805
Inventor 金光东俞智允柳亨杬朴修钟李基元朴基勋吴相锡
Owner IND ACADEMIC COOP FOUND GYEONGSANG NAT UNIV
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